The Effect of Food (High Fat and Low Fat Breakfast) on the Pharmacokinetics of Regorafenib
Completed
Bayer
Phase 1
2009-10-01
An open label, three way crossover study to determine the effect of a high fat breakfast or a
low fat breakfast on the pharmacokinetics of a single dose of regorafenib.
Regorafenib in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor
Completed
Bayer
Phase 2
2010-02-01
The purpose of this research study is to determine the safety and activity of regorafenib in
participants with advanced gastrointestinal stromal tumor (GIST) if the standard approved
therapies, imatinib and sunitinib, have failed to control the disease. Regorafenib is a drug
that blocks abnormally active signaling enzymes called "tyrosine kinases" which are important
to the growth of GIST. This "tyrosine kinase inhibition" is similar to the way that both
imatinib and sunitinib work; however, regorafenib blocks certain additional signaling
pathways that are not blocked by imatinib or sunitinib. Regorafenib has been not been tested
in GIST participants before this research study.
Regorafenib in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor
Completed
Brigham and Women's Hospital
Phase 2
2010-02-01
The purpose of this research study is to determine the safety and activity of regorafenib in
participants with advanced gastrointestinal stromal tumor (GIST) if the standard approved
therapies, imatinib and sunitinib, have failed to control the disease. Regorafenib is a drug
that blocks abnormally active signaling enzymes called "tyrosine kinases" which are important
to the growth of GIST. This "tyrosine kinase inhibition" is similar to the way that both
imatinib and sunitinib work; however, regorafenib blocks certain additional signaling
pathways that are not blocked by imatinib or sunitinib. Regorafenib has been not been tested
in GIST participants before this research study.
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