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Last Updated: May 28, 2022

CLINICAL TRIALS PROFILE FOR PYRIDOSTIGMINE BROMIDE


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All Clinical Trials for Pyridostigmine Bromide

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00223691 ↗ Treatment of Orthostatic Hypotension in Autonomic Failure Completed Vanderbilt University Phase 1 2002-03-01 The autonomic nervous system serves multiple regulatory functions in the body, including the regulation of blood pressure and heart rate, gut motility, sweating and sexual function. There are several diseases characterized by abnormal function of the autonomic nervous system. Medications can also alter autonomic function. Impairment of the autonomic nervous system by diseases or drugs may lead to several symptoms, including blood pressure problems (e.g., high blood pressure lying down and low blood pressure on standing), sweating abnormalities, constipation or diarrhea and sexual dysfunction. Because treatment options for these patients are limited. We propose to study patients autonomic failure and low blood pressure upon standing and determine the cause of their disease by history and examination and their response to autonomic testing which have already been standardized in our laboratory. Based on their possible cause, we will tests different medications that may alleviate their symptoms.
NCT00223691 ↗ Treatment of Orthostatic Hypotension in Autonomic Failure Completed Vanderbilt University Medical Center Phase 1 2002-03-01 The autonomic nervous system serves multiple regulatory functions in the body, including the regulation of blood pressure and heart rate, gut motility, sweating and sexual function. There are several diseases characterized by abnormal function of the autonomic nervous system. Medications can also alter autonomic function. Impairment of the autonomic nervous system by diseases or drugs may lead to several symptoms, including blood pressure problems (e.g., high blood pressure lying down and low blood pressure on standing), sweating abnormalities, constipation or diarrhea and sexual dysfunction. Because treatment options for these patients are limited. We propose to study patients autonomic failure and low blood pressure upon standing and determine the cause of their disease by history and examination and their response to autonomic testing which have already been standardized in our laboratory. Based on their possible cause, we will tests different medications that may alleviate their symptoms.
NCT00953914 ↗ Pyridostigmine and Its Effects on Autonomic Modulation in Diabetic Patients Completed Hospital de Clinicas de Porto Alegre N/A 2005-03-01 The purpose of the study is to determine if pyridostigmine bromide improves heart rate variability of type 2 diabetes mellitus subjects with cardiovascular autonomic neuropathy.
NCT01370512 ↗ Droxidopa / Pyridostigmine in Orthostatic Hypotension Completed National Institute of Neurological Disorders and Stroke (NINDS) Phase 2 2011-11-01 The hypothesis is that pyridostigmine will improve the safety factor of ganglionic neural transmission, while Droxidopa will replete the postganglionic neuron of norepinephrine (NE). This combination should result in enhanced orthostatic release of NE. The investigators have already demonstrated that pyridostigmine does not raise supine blood pressure.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Pyridostigmine Bromide

Condition Name

Condition Name for Pyridostigmine Bromide
Intervention Trials
Orthostatic Hypotension 3
Immuno-senescence 1
Autonomic Integrity 1
Postural Orthostatic Tachycardia Syndrome 1
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Condition MeSH

Condition MeSH for Pyridostigmine Bromide
Intervention Trials
Hypotension 6
Hypotension, Orthostatic 5
Infection 2
HIV Infections 2
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Clinical Trial Locations for Pyridostigmine Bromide

Trials by Country

Trials by Country for Pyridostigmine Bromide
Location Trials
United States 14
Mexico 3
Netherlands 1
Korea, Republic of 1
Brazil 1
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Trials by US State

Trials by US State for Pyridostigmine Bromide
Location Trials
New York 3
New Jersey 2
North Carolina 2
Tennessee 2
Ohio 1
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Clinical Trial Progress for Pyridostigmine Bromide

Clinical Trial Phase

Clinical Trial Phase for Pyridostigmine Bromide
Clinical Trial Phase Trials
Phase 4 1
Phase 3 1
Phase 2/Phase 3 2
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Clinical Trial Status

Clinical Trial Status for Pyridostigmine Bromide
Clinical Trial Phase Trials
Completed 9
Recruiting 3
Unknown status 2
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Clinical Trial Sponsors for Pyridostigmine Bromide

Sponsor Name

Sponsor Name for Pyridostigmine Bromide
Sponsor Trials
Vanderbilt University Medical Center 2
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran 2
James J. Peters Veterans Affairs Medical Center 2
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Sponsor Type

Sponsor Type for Pyridostigmine Bromide
Sponsor Trials
Other 24
NIH 4
U.S. Fed 4
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