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Last Updated: October 14, 2019

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CLINICAL TRIALS PROFILE FOR PYRAZINAMIDE

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Clinical Trials for Pyrazinamide

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00000636 Prophylaxis Against Tuberculosis (TB) in Patients With Human Immunodeficiency Virus (HIV) Infection and Confirmed Latent Tuberculous Infection Completed National Institute of Allergy and Infectious Diseases (NIAID) N/A 1969-12-31 To evaluate and compare the effectiveness of a 2-month regimen of rifampin and pyrazinamide versus a 1-year course of isoniazid (INH) to prevent the development of tuberculosis in patients who are coinfected with HIV and latent Mycobacterium tuberculosis (MTb). Current guidelines recommend 6 to 12 months of treatment with INH for purified protein derivative (PPD)-positive individuals. Problems with this treatment include compliance, adverse reaction, and the possibility of not preventing disease due to INH-resistant organisms. Studies suggest that two or three months of rifampin and pyrazinamide may be more effective than longer courses of INH. A two-month prevention course should help to increase compliance. In addition, the use of two drugs (rifampin and pyrazinamide) may help overcome problems with drug resistance.
NCT00000638 Preventive Treatment Against Tuberculosis (TB) in Patients With Human Immunodeficiency Virus (HIV) Infection and Confirmed Latent Tuberculous Infection Completed Hoechst Marion Roussel N/A 1969-12-31 To evaluate and compare the safety and effectiveness of a one-year course of isoniazid (INH) versus a two-month course of rifampin plus pyrazinamide for the prevention of reactivation tuberculosis in individuals infected with both HIV and latent (inactive) Mycobacterium tuberculosis. Current guidelines from the American Thoracic Society and the Centers for Disease Control recommend 6 to 12 months of INH for PPD (purified protein derivative)-positive individuals. Although the effectiveness of this treatment is not known for HIV-infected individuals, several studies using INH to prevent tuberculosis in presumably normal hosts have shown 60 to 80 percent effectiveness. Problems with this treatment include compliance, adverse reaction, and the possibility of not preventing disease due to tuberculosis organisms being resistant to INH. A two-month preventive treatment plan should help in increasing compliance. In addition, the use of two drugs (rifampin / pyrazinamide) may help overcome problems with drug resistance. If this study shows equal or greater effectiveness of the two-month rifampin / pyrazinamide treatment, it could alter the approach to tuberculosis prevention for both HIV-positive and HIV-negative individuals.
NCT00000638 Preventive Treatment Against Tuberculosis (TB) in Patients With Human Immunodeficiency Virus (HIV) Infection and Confirmed Latent Tuberculous Infection Completed Lederle Laboratories N/A 1969-12-31 To evaluate and compare the safety and effectiveness of a one-year course of isoniazid (INH) versus a two-month course of rifampin plus pyrazinamide for the prevention of reactivation tuberculosis in individuals infected with both HIV and latent (inactive) Mycobacterium tuberculosis. Current guidelines from the American Thoracic Society and the Centers for Disease Control recommend 6 to 12 months of INH for PPD (purified protein derivative)-positive individuals. Although the effectiveness of this treatment is not known for HIV-infected individuals, several studies using INH to prevent tuberculosis in presumably normal hosts have shown 60 to 80 percent effectiveness. Problems with this treatment include compliance, adverse reaction, and the possibility of not preventing disease due to tuberculosis organisms being resistant to INH. A two-month preventive treatment plan should help in increasing compliance. In addition, the use of two drugs (rifampin / pyrazinamide) may help overcome problems with drug resistance. If this study shows equal or greater effectiveness of the two-month rifampin / pyrazinamide treatment, it could alter the approach to tuberculosis prevention for both HIV-positive and HIV-negative individuals.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Pyrazinamide

Condition Name

Condition Name for Pyrazinamide
Intervention Trials
Tuberculosis 43
HIV Infections 10
Tuberculosis, Pulmonary 9
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Condition MeSH

Condition MeSH for Pyrazinamide
Intervention Trials
Tuberculosis 83
Tuberculosis, Pulmonary 29
HIV Infections 11
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Clinical Trial Locations for Pyrazinamide

Trials by Country

Trials by Country for Pyrazinamide
Location Trials
United States 118
South Africa 40
China 34
Brazil 17
Canada 15
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Trials by US State

Trials by US State for Pyrazinamide
Location Trials
California 11
New York 9
Texas 8
Maryland 8
New Jersey 7
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Clinical Trial Progress for Pyrazinamide

Clinical Trial Phase

Clinical Trial Phase for Pyrazinamide
Clinical Trial Phase Trials
Phase 4 11
Phase 3 21
Phase 2/Phase 3 3
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Clinical Trial Status

Clinical Trial Status for Pyrazinamide
Clinical Trial Phase Trials
Completed 35
Not yet recruiting 20
Recruiting 15
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Clinical Trial Sponsors for Pyrazinamide

Sponsor Name

Sponsor Name for Pyrazinamide
Sponsor Trials
National Institute of Allergy and Infectious Diseases (NIAID) 12
Global Alliance for TB Drug Development 9
Centers for Disease Control and Prevention 7
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Sponsor Type

Sponsor Type for Pyrazinamide
Sponsor Trials
Other 224
Industry 13
NIH 13
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