Phase4/Symbicort® Versus Pulmicort Flexhaler® in African Americans
Completed
AstraZeneca
Phase 4
2008-06-01
To compare the efficacy of SYMBICORT® pMDI 160/4.5 μg x 2 actuations twice daily (bid) to
that of budesonide inhalation powder DPI 180 μg x 2 inhalations bid, in African
American(self-reported) subjects with inhaled corticosteroid (ICS) dependent asthma.
Use of Symbicort or Pulmicort to Treat Viral-mediated Asthma Exacerbations
Completed
AstraZeneca
N/A
2009-09-01
This is an investigator-initiated study in which Dr. Nadeau wrote the protocol and received
funding from an Astra Zeneca grant to direct, perform, and monitor the study on her own with
Stanford staff. We hypothesize that the budesonide/formoterol combination improves the
efficacy of budesonide alone.
Use of Symbicort or Pulmicort to Treat Viral-mediated Asthma Exacerbations
Completed
Stanford University
N/A
2009-09-01
This is an investigator-initiated study in which Dr. Nadeau wrote the protocol and received
funding from an Astra Zeneca grant to direct, perform, and monitor the study on her own with
Stanford staff. We hypothesize that the budesonide/formoterol combination improves the
efficacy of budesonide alone.
Acute Airway Vascular Smooth Muscle Effects of Inhaled Budesonide
Completed
AstraZeneca
N/A
2008-07-01
Glucocorticosteroids recently have been shown to have non-genomic actions that are plasma
membrane-mediated and do not require gene transcription and translation. One of these
non-genomic effects is the inhibition of adrenergic agonist transport into airway vascular
smooth muscle cells with an increase of adrenergic agonist concentrations at adrenergic
receptor sites and enhance the physiological effects of endogenous adrenergic agonists (e.g.
locally released norepinephrine from noradrenergic neurons) or exogenous adrenergic agonists
(e.g. inhaled beta-adrenergic agonists).
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