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Generated: February 23, 2019

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CLINICAL TRIALS PROFILE FOR PROVOCHOLINE

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Clinical Trials for Provocholine

Trial ID Title Status Sponsor Phase Summary
NCT01064245 Physiology of Cough in Asthma: Comparison of Sensory-Mechanical Responses to Mannitol and Methacholine Challenge Tests Active, not recruiting Queen's University (William M Spear / Start Memorial Fund) N/A Cough is a common, disruptive and at times disabling symptom which often prompts patients to seek medical attention. Determining the cause(s) of chronic cough can be challenging, and costly. Asthma and other airway disorders are among the most common causes of chronic cough; and cough can be the sole symptom of asthma. Little is known about why some patients with asthma primarily cough and do not develop the other symptoms of asthma such as shortness of breath or wheeze. Improved understanding of the reasons for these different manifestations may lead to new and more effective treatment strategies. We have notices differences in pressure measurements inside the chest in patients who mostly cough during induced bronchoconstriction, which might be part of the explanation for varying symptoms. This study will compare lung mechanical responses during methacholine and mannitol-induced induced airway narrowing between typical asthma, cough variant asthma (CVA) and an airway inflammatory disorder that is not asthma.The purpose of this research is to explore the pathophysiology and sensory-mechanics of cough in individuals with asthma, CVA and methacholine-induced cough but normal airway sensitivity using mannitol and high-dose methacholine bronchoprovocation testing.
NCT01064245 Physiology of Cough in Asthma: Comparison of Sensory-Mechanical Responses to Mannitol and Methacholine Challenge Tests Active, not recruiting The Ontario Thoracic Society of the Ontario Lung Association N/A Cough is a common, disruptive and at times disabling symptom which often prompts patients to seek medical attention. Determining the cause(s) of chronic cough can be challenging, and costly. Asthma and other airway disorders are among the most common causes of chronic cough; and cough can be the sole symptom of asthma. Little is known about why some patients with asthma primarily cough and do not develop the other symptoms of asthma such as shortness of breath or wheeze. Improved understanding of the reasons for these different manifestations may lead to new and more effective treatment strategies. We have notices differences in pressure measurements inside the chest in patients who mostly cough during induced bronchoconstriction, which might be part of the explanation for varying symptoms. This study will compare lung mechanical responses during methacholine and mannitol-induced induced airway narrowing between typical asthma, cough variant asthma (CVA) and an airway inflammatory disorder that is not asthma.The purpose of this research is to explore the pathophysiology and sensory-mechanics of cough in individuals with asthma, CVA and methacholine-induced cough but normal airway sensitivity using mannitol and high-dose methacholine bronchoprovocation testing.
NCT01064245 Physiology of Cough in Asthma: Comparison of Sensory-Mechanical Responses to Mannitol and Methacholine Challenge Tests Active, not recruiting Queen's University N/A Cough is a common, disruptive and at times disabling symptom which often prompts patients to seek medical attention. Determining the cause(s) of chronic cough can be challenging, and costly. Asthma and other airway disorders are among the most common causes of chronic cough; and cough can be the sole symptom of asthma. Little is known about why some patients with asthma primarily cough and do not develop the other symptoms of asthma such as shortness of breath or wheeze. Improved understanding of the reasons for these different manifestations may lead to new and more effective treatment strategies. We have notices differences in pressure measurements inside the chest in patients who mostly cough during induced bronchoconstriction, which might be part of the explanation for varying symptoms. This study will compare lung mechanical responses during methacholine and mannitol-induced induced airway narrowing between typical asthma, cough variant asthma (CVA) and an airway inflammatory disorder that is not asthma.The purpose of this research is to explore the pathophysiology and sensory-mechanics of cough in individuals with asthma, CVA and methacholine-induced cough but normal airway sensitivity using mannitol and high-dose methacholine bronchoprovocation testing.
NCT01618929 Effects of Montelukast in Asthmatic Children With and Without Food Allergy Unknown status Merck Sharp & Dohme Corp. Phase 4 - To search the effects of montelukast on the airway inflammation including FEV1%, FEV1%/FVC, the provocholine® (methacoline chloride powder for inhalation) challenge tests, the leukotriene levels in the exhaled breath condensate in asthmatic children with and without food allergy aged 6-18 years old. - To define the patient groups with good response to montelukast and to define the parameters which predict the good response.
NCT01618929 Effects of Montelukast in Asthmatic Children With and Without Food Allergy Unknown status Hacettepe University Phase 4 - To search the effects of montelukast on the airway inflammation including FEV1%, FEV1%/FVC, the provocholine® (methacoline chloride powder for inhalation) challenge tests, the leukotriene levels in the exhaled breath condensate in asthmatic children with and without food allergy aged 6-18 years old. - To define the patient groups with good response to montelukast and to define the parameters which predict the good response.
NCT01642745 Mannitol (Aridol) and Methacholine (Provocholine) Responsiveness Completed University of Saskatchewan Phase 4 The study will compare the airway responses to two bronchoconstricting agents, mannitol and methacholine.
NCT01699594 Change in Airway Responsiveness After Allergen Exposure Completed University of Saskatchewan N/A Exposure to allergens changes the way the airway responds to some stimuli (methacholine). The investigators will look at whether or not exposure to allergens changes the way the airway responds to a different stimuli (mannitol) and compare that with the known stimuli (methacholine).
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Provocholine

Condition Name

Condition Name for Provocholine
Intervention Trials
Asthma 5
Cough Variant Asthma 2
Children 1
Bronchial Asthma 1
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Condition MeSH

Condition MeSH for Provocholine
Intervention Trials
Asthma 3
Cough 2
Respiratory Aspiration 1
Hyperventilation 1
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Clinical Trial Locations for Provocholine

Trials by Country

Trials by Country for Provocholine
Location Trials
Canada 6
Turkey 1
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Clinical Trial Progress for Provocholine

Clinical Trial Phase

Clinical Trial Phase for Provocholine
Clinical Trial Phase Trials
Phase 4 4
Phase 3 1
N/A 2
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Clinical Trial Status

Clinical Trial Status for Provocholine
Clinical Trial Phase Trials
Completed 2
Recruiting 2
Active, not recruiting 1
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Clinical Trial Sponsors for Provocholine

Sponsor Name

Sponsor Name for Provocholine
Sponsor Trials
University of Saskatchewan 4
Queen's University 2
Hacettepe University 1
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Sponsor Type

Sponsor Type for Provocholine
Sponsor Trials
Other 9
Industry 1
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Serving hundreds of leading biopharmaceutical companies globally:

Chubb
Express Scripts
McKesson
Colorcon
Fish and Richardson
Farmers Insurance
Julphar
Fuji
Federal Trade Commission

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