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Generated: February 23, 2019

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CLINICAL TRIALS PROFILE FOR PROPOFOL

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Clinical Trials for Propofol

Trial ID Title Status Sponsor Phase Summary
NCT00004424 Randomized Study of Propofol Versus Fentanyl and Midazolam in Pediatric Patients Requiring Mechanical Ventilation and Sedation Therapy Completed Case Western Reserve University N/A OBJECTIVES: I. Assess the degree of amnesia afforded by study sedatives relative to the patient's intensive care unit experiences. II. Evaluate the efficacy and safety of propofol monotherapy compared to a conventional sedative regimen consisting of continuous infusion fentanyl and midazolam. III. Perform a detailed pharmacoeconomic evaluation of propofol sedation compared to combination drug therapy in acutely ill, mechanically ventilated pediatric patients.
NCT00004424 Randomized Study of Propofol Versus Fentanyl and Midazolam in Pediatric Patients Requiring Mechanical Ventilation and Sedation Therapy Completed FDA Office of Orphan Products Development N/A OBJECTIVES: I. Assess the degree of amnesia afforded by study sedatives relative to the patient's intensive care unit experiences. II. Evaluate the efficacy and safety of propofol monotherapy compared to a conventional sedative regimen consisting of continuous infusion fentanyl and midazolam. III. Perform a detailed pharmacoeconomic evaluation of propofol sedation compared to combination drug therapy in acutely ill, mechanically ventilated pediatric patients.
NCT00095251 MENDS Study: Trial in Ventilated ICU Patients Comparing an Alpha2 Agonist Versus a Gamma Aminobutyric Acid (GABA)-Agonist to Determine Delirium Rates, Efficacy of Sedation, Analgesia and Discharge Cognitive Status Active, not recruiting Vanderbilt University Medical Center Phase 2 Delirium has recently been shown as a predictor of death, increased cost, and longer length of stay in ventilated patients. Sedative and analgesic medications relieve anxiety and pain, but may contribute to patients' transitioning into delirium. It is possible that modifying the paradigm for sedation using novel therapies targeted at different receptors, such as dexmedetomidine targeting alpha2 receptors and sparing the GABA receptors, could provide efficacious sedation yet reduce the development, duration, and severity of acute brain dysfunction (delirium).
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Propofol

Condition Name

Condition Name for Propofol
Intervention Trials
Anesthesia 107
Pain 47
Postoperative Pain 40
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Condition MeSH

Condition MeSH for Propofol
Intervention Trials
Pain, Postoperative 87
Delirium 43
Vomiting 27
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Clinical Trial Locations for Propofol

Trials by Country

Trials by Country for Propofol
Location Trials
United States 360
Korea, Republic of 109
China 82
France 66
Egypt 59
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Trials by US State

Trials by US State for Propofol
Location Trials
New York 30
Texas 27
California 23
Illinois 22
Ohio 21
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Clinical Trial Progress for Propofol

Clinical Trial Phase

Clinical Trial Phase for Propofol
Clinical Trial Phase Trials
Phase 4 483
Phase 3 107
Phase 2/Phase 3 34
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Clinical Trial Status

Clinical Trial Status for Propofol
Clinical Trial Phase Trials
Completed 551
Recruiting 260
Not yet recruiting 142
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Clinical Trial Sponsors for Propofol

Sponsor Name

Sponsor Name for Propofol
Sponsor Trials
Yonsei University 45
Assiut University 22
Mansoura University 19
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Sponsor Type

Sponsor Type for Propofol
Sponsor Trials
Other 1330
Industry 114
NIH 10
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