Safety and Tolerance of Zidovudine With Probenecid and the Effect of Probenecid on Zidovudine Pharmacokinetics Over Four Weeks
Completed
National Institute of Allergy and Infectious Diseases (NIAID)
N/A
1969-12-31
To evaluate the interaction of probenecid with zidovudine (AZT). Because AZT is eliminated
quickly from the body, it must be taken frequently. A previous study showed that probenecid
slowed the elimination of AZT without side effects, but that study lasted only 5 days. This
study is to see whether this effect continues for 1 month and whether the continuation of
probenecid and AZT is free of side effects over 1 month.
Influence of Probenecid and Quinine on the Pharmacokinetics of Azidothymidine
Completed
National Institute of Allergy and Infectious Diseases (NIAID)
N/A
1969-12-31
Part I studies the effect of quinine on how zidovudine (AZT) is used by the body and
eliminated through the kidneys in HIV infected patients. Part II studies the effect of
probenecid and quinine on the same aspects.
Because AZT leaves the bloodstream quickly, patients must take the drug frequently to keep
adequate amounts in their bodies. Probenecid and quinine may slow down the rate at which AZT
leaves the body. Therefore, taking these drugs along with AZT may reduce the amount of AZT
needed for treatment.
To evaluate short-term and long-term safety and efficacy of intravenous cidofovir (HPMPC) for
treatment of small peripheral cytomegalovirus (CMV) retinitis lesions. To provide data on the
relative safety and efficacy of 2 doses of HPMPC as maintenance regimens.
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