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Generated: December 17, 2018

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CLINICAL TRIALS PROFILE FOR PROBENECID

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Clinical Trials for Probenecid

Trial ID Title Status Sponsor Phase Summary
NCT00000670 Safety and Tolerance of Zidovudine With Probenecid and the Effect of Probenecid on Zidovudine Pharmacokinetics Over Four Weeks Completed National Institute of Allergy and Infectious Diseases (NIAID) N/A To evaluate the interaction of probenecid with zidovudine (AZT). Because AZT is eliminated quickly from the body, it must be taken frequently. A previous study showed that probenecid slowed the elimination of AZT without side effects, but that study lasted only 5 days. This study is to see whether this effect continues for 1 month and whether the continuation of probenecid and AZT is free of side effects over 1 month.
NCT00000706 Influence of Probenecid and Quinine on the Pharmacokinetics of Azidothymidine Completed National Institute of Allergy and Infectious Diseases (NIAID) N/A Part I studies the effect of quinine on how zidovudine (AZT) is used by the body and eliminated through the kidneys in HIV infected patients. Part II studies the effect of probenecid and quinine on the same aspects. Because AZT leaves the bloodstream quickly, patients must take the drug frequently to keep adequate amounts in their bodies. Probenecid and quinine may slow down the rate at which AZT leaves the body. Therefore, taking these drugs along with AZT may reduce the amount of AZT needed for treatment.
NCT00000799 HPMPC (Cidofovir) Peripheral CMV Retinitis Trial Protocol Completed Gilead Sciences N/A To evaluate short-term and long-term safety and efficacy of intravenous cidofovir (HPMPC) for treatment of small peripheral cytomegalovirus (CMV) retinitis lesions. To provide data on the relative safety and efficacy of 2 doses of HPMPC as maintenance regimens.
NCT00000799 HPMPC (Cidofovir) Peripheral CMV Retinitis Trial Protocol Completed National Institute of Allergy and Infectious Diseases (NIAID) N/A To evaluate short-term and long-term safety and efficacy of intravenous cidofovir (HPMPC) for treatment of small peripheral cytomegalovirus (CMV) retinitis lesions. To provide data on the relative safety and efficacy of 2 doses of HPMPC as maintenance regimens.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Probenecid

Condition Name

Condition Name for Probenecid
Intervention Trials
HIV Infections 10
Cytomegalovirus Retinitis 7
Healthy 5
Antibiotic Resistant Infection 3
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Condition MeSH

Condition MeSH for Probenecid
Intervention Trials
HIV Infections 11
Retinitis 7
Cytomegalovirus Retinitis 7
Infection 5
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Clinical Trial Locations for Probenecid

Trials by Country

Trials by Country for Probenecid
Location Trials
United States 133
Canada 8
Germany 6
South Africa 6
New Zealand 5
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Trials by US State

Trials by US State for Probenecid
Location Trials
California 11
Texas 9
New York 8
Maryland 8
North Carolina 6
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Clinical Trial Progress for Probenecid

Clinical Trial Phase

Clinical Trial Phase for Probenecid
Clinical Trial Phase Trials
Phase 4 5
Phase 3 7
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for Probenecid
Clinical Trial Phase Trials
Completed 31
Not yet recruiting 5
Unknown status 4
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Clinical Trial Sponsors for Probenecid

Sponsor Name

Sponsor Name for Probenecid
Sponsor Trials
National Institute of Allergy and Infectious Diseases (NIAID) 8
National Institutes of Health (NIH) 4
Iterum Therapeutics, US Limited 3
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Sponsor Type

Sponsor Type for Probenecid
Sponsor Trials
Industry 22
Other 21
NIH 17
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Serving hundreds of leading biopharmaceutical companies globally:

Express Scripts
Cantor Fitzgerald
Mallinckrodt
Chinese Patent Office
Moodys
Julphar
Accenture
Colorcon
Queensland Health

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