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Last Updated: December 6, 2022

CLINICAL TRIALS PROFILE FOR PRIMAQUINE PHOSPHATE


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All Clinical Trials for Primaquine Phosphate

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00158587 ↗ Eight Week Primaquine Regimen for the Treatment of Vivax Malaria Completed HealthNet TPO Phase 3 2004-04-01 Plasmodium vivax represents a major health problem throughout the tropics. Outside Africa it accounts for over 50% of cases, affecting an estimated 70-80 million people per year. A substantial proportion of clinical cases are not caused by infective bites of Anopheles spp, but by activation of latent hypnozoites in the liver. These relapses may significantly impede development since each illness may result in 5-15 days of absence from work or school. Primaquine(PQ) is the only drug available that eliminates hypnozoites, though its use is beset by clinical problems; it may precipitate haemolytic anaemia in individuals deficient in the blood enzyme glucose 6 phosphate dehydrogenase (G6PD). Without affordable G6PD testing, primaquine use is precluded. Evidence suggests, however, that a course of 8 weekly doses may be a safe and effective alternative to the traditional 14 day course of the drug. The aim of the proposed study, therefore, is to test whether 8 weekly doses of primaquine is as effective as the 14 day course at preventing relapse malaria, without the risk of hemolysis in G6PD deficient individuals.
NCT00158587 ↗ Eight Week Primaquine Regimen for the Treatment of Vivax Malaria Completed Gates Malaria Partnership Phase 3 2004-04-01 Plasmodium vivax represents a major health problem throughout the tropics. Outside Africa it accounts for over 50% of cases, affecting an estimated 70-80 million people per year. A substantial proportion of clinical cases are not caused by infective bites of Anopheles spp, but by activation of latent hypnozoites in the liver. These relapses may significantly impede development since each illness may result in 5-15 days of absence from work or school. Primaquine(PQ) is the only drug available that eliminates hypnozoites, though its use is beset by clinical problems; it may precipitate haemolytic anaemia in individuals deficient in the blood enzyme glucose 6 phosphate dehydrogenase (G6PD). Without affordable G6PD testing, primaquine use is precluded. Evidence suggests, however, that a course of 8 weekly doses may be a safe and effective alternative to the traditional 14 day course of the drug. The aim of the proposed study, therefore, is to test whether 8 weekly doses of primaquine is as effective as the 14 day course at preventing relapse malaria, without the risk of hemolysis in G6PD deficient individuals.
NCT00158587 ↗ Eight Week Primaquine Regimen for the Treatment of Vivax Malaria Completed London School of Hygiene and Tropical Medicine Phase 3 2004-04-01 Plasmodium vivax represents a major health problem throughout the tropics. Outside Africa it accounts for over 50% of cases, affecting an estimated 70-80 million people per year. A substantial proportion of clinical cases are not caused by infective bites of Anopheles spp, but by activation of latent hypnozoites in the liver. These relapses may significantly impede development since each illness may result in 5-15 days of absence from work or school. Primaquine(PQ) is the only drug available that eliminates hypnozoites, though its use is beset by clinical problems; it may precipitate haemolytic anaemia in individuals deficient in the blood enzyme glucose 6 phosphate dehydrogenase (G6PD). Without affordable G6PD testing, primaquine use is precluded. Evidence suggests, however, that a course of 8 weekly doses may be a safe and effective alternative to the traditional 14 day course of the drug. The aim of the proposed study, therefore, is to test whether 8 weekly doses of primaquine is as effective as the 14 day course at preventing relapse malaria, without the risk of hemolysis in G6PD deficient individuals.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Primaquine Phosphate

Condition Name

Condition Name for Primaquine Phosphate
Intervention Trials
Malaria 13
Vivax Malaria 6
Malaria, Vivax 5
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Condition MeSH

Condition MeSH for Primaquine Phosphate
Intervention Trials
Malaria 27
Malaria, Vivax 14
Glucosephosphate Dehydrogenase Deficiency 5
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Clinical Trial Locations for Primaquine Phosphate

Trials by Country

Trials by Country for Primaquine Phosphate
Location Trials
Thailand 12
Brazil 7
Indonesia 6
Vietnam 4
Afghanistan 4
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Trials by US State

Trials by US State for Primaquine Phosphate
Location Trials
Mississippi 1
California 1
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Clinical Trial Progress for Primaquine Phosphate

Clinical Trial Phase

Clinical Trial Phase for Primaquine Phosphate
Clinical Trial Phase Trials
Phase 4 11
Phase 3 9
Phase 2/Phase 3 3
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Clinical Trial Status

Clinical Trial Status for Primaquine Phosphate
Clinical Trial Phase Trials
Completed 29
Not yet recruiting 5
Unknown status 2
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Clinical Trial Sponsors for Primaquine Phosphate

Sponsor Name

Sponsor Name for Primaquine Phosphate
Sponsor Trials
University of Oxford 13
London School of Hygiene and Tropical Medicine 8
Mahidol University 4
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Sponsor Type

Sponsor Type for Primaquine Phosphate
Sponsor Trials
Other 92
Industry 4
U.S. Fed 2
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