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Generated: December 16, 2018

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CLINICAL TRIALS PROFILE FOR PRIMAQUINE

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Clinical Trials for Primaquine

Trial ID Title Status Sponsor Phase Summary
NCT00000640 A Phase III Comparative Study of Dapsone / Trimethoprim and Clindamycin / Primaquine Versus Sulfamethoxazole / Trimethoprim in the Treatment of Mild-to-Moderate PCP in Patients With AIDS Completed Glaxo Wellcome Phase 3 To evaluate the effectiveness of two oral treatments for mild to moderate Pneumocystis carinii pneumonia (PCP): dapsone/trimethoprim or clindamycin/primaquine as compared to a standard treatment program of sulfamethoxazole/trimethoprim (SMX/TMP) to assess the tolerance of these two alternative treatments as compared to the standard treatment of SMX/TMP. Per 09/09/92 amendment, to assess the efficacy and tolerance of these two alternative treatments in patients who are intolerant to SMX/TMP. The type of treatment being studied has the advantages of wide applicability throughout the world (including developing countries) and low cost. An oral treatment is more accessible to patients than drugs given by injection or by inhalation.
NCT00000640 A Phase III Comparative Study of Dapsone / Trimethoprim and Clindamycin / Primaquine Versus Sulfamethoxazole / Trimethoprim in the Treatment of Mild-to-Moderate PCP in Patients With AIDS Completed Jacobus Pharmaceutical Phase 3 To evaluate the effectiveness of two oral treatments for mild to moderate Pneumocystis carinii pneumonia (PCP): dapsone/trimethoprim or clindamycin/primaquine as compared to a standard treatment program of sulfamethoxazole/trimethoprim (SMX/TMP) to assess the tolerance of these two alternative treatments as compared to the standard treatment of SMX/TMP. Per 09/09/92 amendment, to assess the efficacy and tolerance of these two alternative treatments in patients who are intolerant to SMX/TMP. The type of treatment being studied has the advantages of wide applicability throughout the world (including developing countries) and low cost. An oral treatment is more accessible to patients than drugs given by injection or by inhalation.
NCT00000640 A Phase III Comparative Study of Dapsone / Trimethoprim and Clindamycin / Primaquine Versus Sulfamethoxazole / Trimethoprim in the Treatment of Mild-to-Moderate PCP in Patients With AIDS Completed National Institute of Allergy and Infectious Diseases (NIAID) Phase 3 To evaluate the effectiveness of two oral treatments for mild to moderate Pneumocystis carinii pneumonia (PCP): dapsone/trimethoprim or clindamycin/primaquine as compared to a standard treatment program of sulfamethoxazole/trimethoprim (SMX/TMP) to assess the tolerance of these two alternative treatments as compared to the standard treatment of SMX/TMP. Per 09/09/92 amendment, to assess the efficacy and tolerance of these two alternative treatments in patients who are intolerant to SMX/TMP. The type of treatment being studied has the advantages of wide applicability throughout the world (including developing countries) and low cost. An oral treatment is more accessible to patients than drugs given by injection or by inhalation.
NCT00000717 The Safety and Efficacy of Clindamycin and Primaquine in the Treatment of Mild - Moderate Pneumocystis Carinii Pneumonia in Patients With AIDS Completed National Institute of Allergy and Infectious Diseases (NIAID) N/A To determine the safety and effectiveness of clindamycin and primaquine in the treatment of mild Pneumocystis carinii pneumonia (PCP) in AIDS patients. As many as 80 percent of AIDS patients experience at least one episode of PCP and about one-third of these patients have a recurrence of the disease. Drugs currently used for treatment of acute PCP are toxic to the majority of AIDS patients. The combination of clindamycin and primaquine reduces the numbers of PCP organisms in laboratory tests and in animal studies. Both drugs can be given orally, concentrate in lung tissue, and have been used safely in humans for treatment of other diseases. It is possible that the combination may prove to be as good or better than standard therapy for PCP and side effects may be less.
NCT00158548 ACT With Chloroquine, Amodiaquine & Sulphadoxine-Pyrimethamine in Pakistan Completed HealthNet TPO Phase 3 Chloroquine resistant falciparum malaria in Pakistan is prevalent in every malarious area examined. Resistance to the favoured second-line treatment, sulphadoxine-pyrimethamine S/P is rising fast. To avert a repetition of the resistance catastrophe that occurred in SE Asia it is critical to preserve the effective life of SP by using it in combination with artesunate. Efficacy of ACT with artesunate in combination with chloroquine, SP or amodiaquine for treatment of malaria (falciparum or vivax) will be examined in malaria patients in Pakistan.
NCT00158548 ACT With Chloroquine, Amodiaquine & Sulphadoxine-Pyrimethamine in Pakistan Completed Pakistan Directorate of Malaria Control Phase 3 Chloroquine resistant falciparum malaria in Pakistan is prevalent in every malarious area examined. Resistance to the favoured second-line treatment, sulphadoxine-pyrimethamine S/P is rising fast. To avert a repetition of the resistance catastrophe that occurred in SE Asia it is critical to preserve the effective life of SP by using it in combination with artesunate. Efficacy of ACT with artesunate in combination with chloroquine, SP or amodiaquine for treatment of malaria (falciparum or vivax) will be examined in malaria patients in Pakistan.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Primaquine

Condition Name

Condition Name for Primaquine
Intervention Trials
Malaria 36
Vivax Malaria 14
Malaria, Vivax 9
Healthy 7
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Condition MeSH

Condition MeSH for Primaquine
Intervention Trials
Malaria 76
Malaria, Vivax 28
Malaria, Falciparum 15
Glucosephosphate Dehydrogenase Deficiency 5
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Clinical Trial Locations for Primaquine

Trials by Country

Trials by Country for Primaquine
Location Trials
Thailand 24
United States 21
Cambodia 11
Brazil 10
Vietnam 9
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Trials by US State

Trials by US State for Primaquine
Location Trials
Ohio 2
Maryland 2
Indiana 2
Illinois 2
Colorado 2
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Clinical Trial Progress for Primaquine

Clinical Trial Phase

Clinical Trial Phase for Primaquine
Clinical Trial Phase Trials
Phase 4 31
Phase 3 18
Phase 2/Phase 3 5
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Clinical Trial Status

Clinical Trial Status for Primaquine
Clinical Trial Phase Trials
Completed 47
Recruiting 27
Not yet recruiting 11
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Clinical Trial Sponsors for Primaquine

Sponsor Name

Sponsor Name for Primaquine
Sponsor Trials
University of Oxford 26
Menzies School of Health Research 12
London School of Hygiene and Tropical Medicine 10
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Sponsor Type

Sponsor Type for Primaquine
Sponsor Trials
Other 227
Industry 19
U.S. Fed 14
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Serving hundreds of leading biopharmaceutical companies globally:

Chinese Patent Office
Dow
Baxter
McKesson
Queensland Health
Cantor Fitzgerald
McKinsey
Healthtrust
Colorcon

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