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Generated: December 18, 2018

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CLINICAL TRIALS PROFILE FOR PREDNISOLONE

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Clinical Trials for Prednisolone

Trial ID Title Status Sponsor Phase Summary
NCT00000138 Herpetic Eye Disease Study (HEDS) I Unknown status National Eye Institute (NEI) Phase 3 To evaluate the efficacy of topical corticosteroids in treating herpes simplex stromal keratitis in conjunction with topical trifluridine. To evaluate the efficacy of oral acyclovir in treating herpes simplex stromal keratitis in patients receiving concomitant topical corticosteroids and trifluridine. To evaluate the efficacy of oral acyclovir in treating herpes simplex iridocyclitis in conjunction with treatment with topical corticosteroids and trifluridine.
NCT00000730 Comparison of Three Treatments for Pneumocystis Pneumonia in AIDS Patients Terminated National Institute of Allergy and Infectious Diseases (NIAID) Phase 3 This study compares three different therapies for treatment of refractory Pneumocystis carinii pneumonia (PCP) in patients with AIDS. "Refractory" means that the patient has failed to respond to at least 4 days of treatment with either of two standard therapies: (1) sulfamethoxazole/trimethoprim (SMX/TMP) or (2) pentamidine (PEN). This study compares therapy with trimetrexate (TMTX) and leucovorin (LCV) to standard therapy and standard therapy plus high-dose steroids (methylprednisolone). The purpose is to find better and safer forms of treatment for PCP in AIDS patients. There is at present no scientific information about the best treatment for an AIDS patient with PCP who is not improving while receiving the standard therapies (SMX/TMP or PEN). New drug treatments are available, including steroid therapy and TMTX, but there is no information proving that these new treatments work better than the standard therapies.
NCT00001409 Genetically Modified Lymphocytes to Treat HIV-Infected Identical Twins - Study Modifications Completed National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 Certain patients enrolled in NIH protocol 94-I-0206 at the Clinical Center may be eligible to participate in one or more of the following new options: - Donor/recipient extension phase - Both the recipient (HIV-infected twin) and donor (non-infected twin) will participate in this extension of the CD4-zeta gene therapy study. It will evaluate the safety and activity of infusing gene-modified CD4+ cells as well as the modified CD8+ cells. - Corticosteroid administration - A corticosteroid, such as prednisone, hydrocortisone or prednisolone, will be added to the interleukin-2 (IL-2) regimen for preventing or treating side effects of IL-2 such as fever and other flu-like symptoms. - Extended follow-up - A more intensive follow-up will be scheduled for patients with substantial numbers of lymphocytes that harbor the CD4-zeta gene. Every 3 months, participants will have blood tests and specialized tests of CD4 counts, HIV-1 viral load and numbers of circulating cells containing the CD4-zeta gene every 3 months> the frequency of follow-up visits may be reduced as time goes by. - IL-2 continuation - Participants will continue to receive periodic treatment with IL-2 to see how long the genetically modified cells persist in the bloodstream and to evaluate the long-term response to IL-2. - Home treatment with interleukin-2 - Participants may receive future IL-2 treatment cycles at home. Home treatment involves less frequent data and safety monitoring and no medical evaluations at the Clinical Center except at the beginning of each cycle.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Prednisolone

Condition Name

Condition Name for Prednisolone
Intervention Trials
Lymphoma 32
Leukemia 19
Asthma 14
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Condition MeSH

Condition MeSH for Prednisolone
Intervention Trials
Lymphoma 75
Prostatic Neoplasms 31
Leukemia 26
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Clinical Trial Locations for Prednisolone

Trials by Country

Trials by Country for Prednisolone
Location Trials
United States 442
United Kingdom 151
Germany 76
Japan 66
Canada 51
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Trials by US State

Trials by US State for Prednisolone
Location Trials
California 34
Texas 29
New York 27
Massachusetts 24
Florida 22
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Clinical Trial Progress for Prednisolone

Clinical Trial Phase

Clinical Trial Phase for Prednisolone
Clinical Trial Phase Trials
Phase 4 95
Phase 3 131
Phase 2/Phase 3 30
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Clinical Trial Status

Clinical Trial Status for Prednisolone
Clinical Trial Phase Trials
Completed 208
Recruiting 86
Unknown status 81
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Clinical Trial Sponsors for Prednisolone

Sponsor Name

Sponsor Name for Prednisolone
Sponsor Trials
GlaxoSmithKline 18
Hoffmann-La Roche 13
Asan Medical Center 9
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Sponsor Type

Sponsor Type for Prednisolone
Sponsor Trials
Other 592
Industry 183
NIH 21
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Serving hundreds of leading biopharmaceutical companies globally:

McKinsey
Merck
QuintilesIMS
Argus Health
Colorcon
Citi
Daiichi Sankyo
Teva
McKesson

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