10-Propargyl-10-Deazaaminopterin in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer
Completed
National Cancer Institute (NCI)
Phase 2
1999-07-01
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of 10-propargyl-10-deazaaminopterin in
treating patients who have stage IIIB or stage IV non-small cell lung cancer.
10-Propargyl-10-Deazaaminopterin in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer
Completed
Memorial Sloan Kettering Cancer Center
Phase 2
1999-07-01
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of 10-propargyl-10-deazaaminopterin in
treating patients who have stage IIIB or stage IV non-small cell lung cancer.
10-Propargyl-10-Deazaaminopterin Plus Probenecid in Treating Patients With Advanced Solid Tumors
Completed
National Cancer Institute (NCI)
Phase 1
2001-05-01
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. Probenecid may increase the effectiveness of
10-propargyl-10-deazaaminopterin by making tumor cells more sensitive to the drug.
PURPOSE: Phase I trial to study the effectiveness of combining
10-propargyl-10-deazaaminopterin and probenecid in treating patients who have advanced solid
tumors.
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