Pradaxa (Dabigatran Etexilate) VTE Prevention After Elective Total Hip or Knee Replacement Surgery
an open, prospective, observational study to collect data on safety (major bleeding events)
and efficacy (symptomatic venous thromboembolism(VTE)) of a switch from Enoxaparin to
dabigatran etexilate in patients with total knee replacement (TKR) and total hip replacement
Treatment of Patients Undergoing Primary Unilateral Elective Total Knee or Hip Replacement With Dabigatran Etexilate
To supplement the current evidence of the effect of Pradaxa® (dabigatran etexilate) on
coagulation parameters, including a calibrated thrombin time test, in patients with moderate
renal impairment undergoing elective total hip- or knee-replacement surgery, this PK/PD study
will be conducted.
Study in Healthy Volunteers of the Reversion by Haemostatic Drugs of the Anticoagulant Effect of New Anti-thrombotics
University Hospital, Grenoble
The purpose of this study is to evaluate whether the effect of the two new anticoagulants,
Dabigatran and Rivaroxaban, can be reversed by non-specific and specific inhibitors. For
Dabigatran the investigators will test the non-specific inhibitors: prothrombin complex
concentrate (PCC), recombinant activated coagulation factor VII, and activated
prothrombin-complex (FEIBA). For Rivaroxaban the investigators will test a specific
Rivaroxaban decoy (FXa-GLAless). This will be done in a laboratory using blood plasma from
healthy male volunteers.
Serving leading biopharmaceutical companies globally:
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors.
Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data.
The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free.
thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user.
Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.
Alerts Available With Subscription
Alerts are available for users with active subscriptions.