CLINICAL TRIALS PROFILE FOR POTASSIUM CHLORIDE 40MEQ IN DEXTROSE 5% AND LACTATED RINGER'S IN PLASTIC CONTAINER

All Clinical Trials for Potassium Chloride 40meq In Dextrose 5% And Lactated Ringer's In Plastic Container

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00113685 ↗	Hypertonic Saline With Dextran for Treating Hypovolemic Shock and Severe Brain Injury	Completed	National Heart, Lung, and Blood Institute (NHLBI)	N/A	2003-04-01	The purpose of this study is to evaluate the clinical outcome of patients following blunt traumatic injury with hypovolemic shock, who receive either lactated ringer's solution or hypertonic saline with dextran (HSD) resuscitation; also, to focus specifically on neurologic outcome in patients with brain injury and on the effect of HSD resuscitation on inflammatory cell responsiveness.
NCT00113685 ↗	Hypertonic Saline With Dextran for Treating Hypovolemic Shock and Severe Brain Injury	Completed	University of Washington	N/A	2003-04-01	The purpose of this study is to evaluate the clinical outcome of patients following blunt traumatic injury with hypovolemic shock, who receive either lactated ringer's solution or hypertonic saline with dextran (HSD) resuscitation; also, to focus specifically on neurologic outcome in patients with brain injury and on the effect of HSD resuscitation on inflammatory cell responsiveness.
NCT00181077 ↗	Hypertonic Saline Use in Preeclampsia	Completed	Johns Hopkins University	Phase 1	2003-06-01	To compare hypertonic saline to Lactated Ringer's solution and assess whether one speeds up the process of getting rid of extra body water faster in women with preeclampsia.
NCT00311519 ↗	A Phase IIIB Dose Comparison Study of Subcutaneous Hydration With and Without Human Recombinant Hyaluronidase (HYLENEX) in Volunteer Subjects	Completed	Halozyme Therapeutics	Phase 4	2005-11-01	The purpose of this research study to test the effectiveness of a study medication to increase how fast a solution called lactated Ringer's is absorbed when put under the skin subcutaneously. The medication to be studied is an enzyme called hyaluronidase, and is a human recombinant form of the enzyme. The drug company name for this medication is Hylenex. Hylenex was currently an investigational medication at the initiation of the study, but received FDA approval during the study. An investigational medication is a medication or formulation of a medication that is not approved by the United States Food and Drug Administration for use in this country but may be used in studies such as this one.
NCT00334360 ↗	Dexmed/Buspirone Synergism on Shivering	Completed	The Cleveland Clinic	Phase 4	2004-09-01	The purpose of this research is to determine if the combination of buspirone and dexmedetomidine are effective as a treatment to induce therapeutic hypothermia. The design of the study includes four study days done in random order. The days are as follows: 1) Control (no drug); 2) Buspirone 60 mg orally; 3) Dexmedetomidine (delivered by a computer-controlled IV infusion to a target plasma concentration of 0.6 ng/ml); and, 3) the combination of buspirone 60 mg and dexmedetomidine (target plasma concentration of 0.6 ng/ml). a 20 cm-long catheter will be inserted into a cubital vein using standard aseptic technique In addition to the PIC line catheter, a simple peripheral catheter will be inserted into the other arm for drug administration. Throughout the study period, mean-skin temperature will be maintained at 31°C by adjusting the temperature of circulating water (Cincinnati Sub-Zero, Cincinnati, OH) and forced-air warmers (Augustine Medical, Inc., Eden Prairie, MN). Furthermore, the back, upper-body, and lower-body will individually be maintained at the designated skin temperature. Lactated Ringer's solution cooled to ≈3°C will be infused via the PIC-line at rates sufficient to decrease tympanic membrane temperature ≈1.5°C/h. Fluid will be administered as long as oxygen consumption or electromyographic intensity (see below) continues to increase or a total of 5 liters of fluid is given. Heart rate will be measured continuously using an electrocardiogram; blood pressure will be determined oscillometrically at 5 min intervals at the ankle. In case heart rate and/or blood pressure changes unexpectedly (by more than 30% of the baseline), the study will stop and the volunteer will be re-warmed immediately.
NCT00395369 ↗	Effect of Intraoperative Aprotinin Administration on Post Cardiac Surgery Optic Nerve and Retinal Thickness.	Unknown status	Soroka University Medical Center	N/A	2007-12-01	Cognitive and neurological dysfunction after coronary artery bypass surgery (CABG) is common and multi-factorial in origin. Several previous studies have shown that intraoperative aprotinin administration may be neuroprotective.in the current prospective randomized study, the effect of intraoperative aprotinin administration on the integrity of the optic nerve and retinal nerve fiber layer will be examined. Optical coherance tomography will be used to examin the optic nerve and retinal nerve fiber layer.
NCT00431743 ↗	Fluid Infusion During Breast Surgery	Unknown status	Rigshospitalet, Denmark	Phase 4	2009-04-01	The investigators want to investigate the effects of two different kinds of fluid infusions given during varicose vein surgery. Both types of fluid are regularly given during surgery, and the investigators want to compare their respective effects on balance, nausea/vomiting and orthostatic function after surgery. The investigators' hypothesis is that using a colloid solution will improve orthostatic function, balance, nausea/vomiting and reduce hospital stay.

Clinical Trial Conditions for Potassium Chloride 40meq In Dextrose 5% And Lactated Ringer's In Plastic Container

Condition Name

Condition Name for Potassium Chloride 40meq In Dextrose 5% And Lactated Ringer's In Plastic Container
Intervention	Trials
Anesthesia	5
Post-ERCP Acute Pancreatitis	4
Cesarean Section	4
Hypotension	4

Condition MeSH

Condition MeSH for Potassium Chloride 40meq In Dextrose 5% And Lactated Ringer's In Plastic Container
Intervention	Trials
Hypotension	16
Pancreatitis	11
Hemorrhage	10
Pain, Postoperative	8

Clinical Trial Locations for Potassium Chloride 40meq In Dextrose 5% And Lactated Ringer's In Plastic Container

Trials by Country

Trials by Country for Potassium Chloride 40meq In Dextrose 5% And Lactated Ringer's In Plastic Container
Location	Trials
Egypt	37
United States	33
China	12
Korea, Republic of	5
Brazil	4

Trials by US State

Trials by US State for Potassium Chloride 40meq In Dextrose 5% And Lactated Ringer's In Plastic Container
Location	Trials
Illinois	4
Pennsylvania	3
Connecticut	3
California	3
Minnesota	2

Clinical Trial Progress for Potassium Chloride 40meq In Dextrose 5% And Lactated Ringer's In Plastic Container

Clinical Trial Phase

Clinical Trial Phase for Potassium Chloride 40meq In Dextrose 5% And Lactated Ringer's In Plastic Container
Clinical Trial Phase	Trials
Phase 4	39
Phase 3	14
Phase 2/Phase 3	4

Clinical Trial Status

Clinical Trial Status for Potassium Chloride 40meq In Dextrose 5% And Lactated Ringer's In Plastic Container
Clinical Trial Phase	Trials
Completed	64
Not yet recruiting	29
Recruiting	26

Clinical Trial Sponsors for Potassium Chloride 40meq In Dextrose 5% And Lactated Ringer's In Plastic Container

Sponsor Name

Sponsor Name for Potassium Chloride 40meq In Dextrose 5% And Lactated Ringer's In Plastic Container
Sponsor	Trials
Ain Shams University	9
Cairo University	6
Mansoura University	5

Sponsor Type

Sponsor Type for Potassium Chloride 40meq In Dextrose 5% And Lactated Ringer's In Plastic Container
Sponsor	Trials
Other	214
Industry	17
NIH	2

Potassium Chloride 40meq in Dextrose 5% and Lactated Ringer's in Plastic Container: Clinical Trials, Market Analysis, and Projections

Introduction

Potassium chloride, particularly in formulations like 40meq in Dextrose 5% and Lactated Ringer's, is a crucial medication for maintaining electrolyte balance and treating various medical conditions. This article delves into the clinical trials, market analysis, and future projections for this specific formulation.

Clinical Use and Indications

Potassium Chloride in Lactated Ringer’s and 5% Dextrose Injection is used as a source of water, electrolytes, and calories. It helps in inducing diuresis and has a metabolic alkalinizing effect, which is beneficial in treating conditions such as hypokalemia and metabolic acidosis[3].

Clinical Trials and Safety

While there are no recent clinical trials specifically focused on Potassium Chloride 40meq in Dextrose 5% and Lactated Ringer's, existing studies and regulatory reviews provide valuable insights into its safety and efficacy.

• Regulatory Approvals: The FDA has approved various formulations of potassium chloride, including oral solutions and intravenous injections. For instance, the FDA approved Potassium Chloride Oral Solution with dosages of 20mEq/15mL and 40mEq/15mL, highlighting the safety and efficacy of potassium chloride formulations[4].
• Safety Considerations: It is crucial to monitor serum potassium levels, especially in patients receiving other products that can cause hyperkalemia. The use of potassium chloride in patients treated with certain medications like ACE inhibitors, angiotensin II receptor antagonists, or immunosuppressants requires careful monitoring to avoid severe hyperkalemia[3].

Improving Safety in Administration

To enhance the safety of potassium chloride administration, particularly in high concentrations, several interventions have been implemented:

• Modified Prescribing Rules: Studies have shown that modifying prescribing rules, such as requiring pharmacists to communicate with physicians for doses exceeding 40 mEq/L, can significantly reduce the number of undiluted potassium chloride prescriptions and enhance patient safety[1].

Market Analysis

The market for potassium chloride is robust and growing, driven by its diverse applications across various industries.

Global Market Size and Growth

• The global potassium chloride market is projected to cross US$ 18,102.7 million by 2033, growing at a CAGR of 3.3% from 2023 to 2033[2].
• The Asia-Pacific region is expected to witness the highest growth in terms of sales, while North America, particularly the United States, will also see significant growth due to advanced farming technologies and increasing demand in the pharmaceutical and food processing sectors[2][5].

Key Markets and Applications

• United States and China: These countries account for over 40% of the global market share, driven by the significant presence of key end-use industries such as agriculture, pharmaceuticals, and food processing. The United States market holds an 86.1% share in the North America industry, primarily due to its use as a fertilizer and in other industrial applications[2].
• Agriculture: The rising use of potassium chloride as a fertilizer to improve soil fertility and enhance crop yields is a major driver of market growth. The increasing global demand for food due to a growing population further fuels this trend[2][5].

Industrial Expansion

• China: China's focus on industrial expansion, particularly in sectors like water treatment, food processing, and agriculture, is expected to drive the demand for potassium chloride in the coming years[2].

Market Projections

Future Trends

• The trend of cultivating eco-friendly resources and the adoption of superior farming technologies are expected to provide significant opportunities for the potassium chloride market to expand. The Asia-Pacific region is anticipated to lead this growth[5].

Regional Growth

• North America: The region is expected to witness growth due to advanced farming practices and increasing demand in pharmaceutical and food processing industries.
• Europe: While Europe may account for a mild share in terms of sales, it is expected to witness moderate growth during the forecast period[5].

Key Takeaways

• Clinical Safety: Ensuring the safe administration of potassium chloride, especially in high concentrations, is crucial and can be achieved through modified prescribing rules and close monitoring.
• Market Growth: The global potassium chloride market is projected to grow significantly, driven by its applications in agriculture, pharmaceuticals, and food processing.
• Regional Dominance: The United States and China are expected to remain prominent in the market, with the Asia-Pacific region leading the growth.

FAQs

What are the primary indications for Potassium Chloride in Lactated Ringer’s and 5% Dextrose Injection?

The primary indications include treating hypokalemia, inducing diuresis, and providing a metabolic alkalinizing effect.

What are the key safety considerations for administering Potassium Chloride?

Monitoring serum potassium levels, especially in patients receiving other hyperkalemia-causing medications, and avoiding use in patients treated with certain diuretics or immunosuppressants are critical.

Which regions are expected to drive the growth of the potassium chloride market?

The Asia-Pacific region, particularly China, and North America, especially the United States, are expected to drive the market growth.

What are the main applications of potassium chloride?

The main applications include use as a fertilizer in agriculture, in pharmaceutical formulations, and in food processing and water treatment industries.

How is the global market for potassium chloride projected to grow?

The global market is projected to cross US$ 18,102.7 million by 2033, growing at a CAGR of 3.3% from 2023 to 2033.

Sources

1. Improving the safety of high-concentration potassium chloride injection - BMJ Open Quality
2. Potassium Chloride Market Size, Growth, Trend & Share | 2033 - Future Market Insights
3. Potassium Chloride in Lactated Ringer's and 5% Dextrose Injection - FDA
4. Potassium Chloride Oral Solution, 20mEq/15mL and 40mEq/15mL - FDA
5. Potassium Chloride Market Revenue, Size | Industry Forecast 2027 - Allied Market Research