CLINICAL TRIALS PROFILE FOR POTASSIUM CHLORIDE 30MEQ IN DEXTROSE 5% AND LACTATED RINGER'S IN PLASTIC CONTAINER

All Clinical Trials for Potassium Chloride 30meq In Dextrose 5% And Lactated Ringer's In Plastic Container

Trial ID	Title	Status	Sponsor	Phase	Start Date	Summary
NCT00113685 ↗	Hypertonic Saline With Dextran for Treating Hypovolemic Shock and Severe Brain Injury	Completed	National Heart, Lung, and Blood Institute (NHLBI)	N/A	2003-04-01	The purpose of this study is to evaluate the clinical outcome of patients following blunt traumatic injury with hypovolemic shock, who receive either lactated ringer's solution or hypertonic saline with dextran (HSD) resuscitation; also, to focus specifically on neurologic outcome in patients with brain injury and on the effect of HSD resuscitation on inflammatory cell responsiveness.
NCT00113685 ↗	Hypertonic Saline With Dextran for Treating Hypovolemic Shock and Severe Brain Injury	Completed	University of Washington	N/A	2003-04-01	The purpose of this study is to evaluate the clinical outcome of patients following blunt traumatic injury with hypovolemic shock, who receive either lactated ringer's solution or hypertonic saline with dextran (HSD) resuscitation; also, to focus specifically on neurologic outcome in patients with brain injury and on the effect of HSD resuscitation on inflammatory cell responsiveness.
NCT00181077 ↗	Hypertonic Saline Use in Preeclampsia	Completed	Johns Hopkins University	Phase 1	2003-06-01	To compare hypertonic saline to Lactated Ringer's solution and assess whether one speeds up the process of getting rid of extra body water faster in women with preeclampsia.
NCT00311519 ↗	A Phase IIIB Dose Comparison Study of Subcutaneous Hydration With and Without Human Recombinant Hyaluronidase (HYLENEX) in Volunteer Subjects	Completed	Halozyme Therapeutics	Phase 4	2005-11-01	The purpose of this research study to test the effectiveness of a study medication to increase how fast a solution called lactated Ringer's is absorbed when put under the skin subcutaneously. The medication to be studied is an enzyme called hyaluronidase, and is a human recombinant form of the enzyme. The drug company name for this medication is Hylenex. Hylenex was currently an investigational medication at the initiation of the study, but received FDA approval during the study. An investigational medication is a medication or formulation of a medication that is not approved by the United States Food and Drug Administration for use in this country but may be used in studies such as this one.
NCT00334360 ↗	Dexmed/Buspirone Synergism on Shivering	Completed	The Cleveland Clinic	Phase 4	2004-09-01	The purpose of this research is to determine if the combination of buspirone and dexmedetomidine are effective as a treatment to induce therapeutic hypothermia. The design of the study includes four study days done in random order. The days are as follows: 1) Control (no drug); 2) Buspirone 60 mg orally; 3) Dexmedetomidine (delivered by a computer-controlled IV infusion to a target plasma concentration of 0.6 ng/ml); and, 3) the combination of buspirone 60 mg and dexmedetomidine (target plasma concentration of 0.6 ng/ml). a 20 cm-long catheter will be inserted into a cubital vein using standard aseptic technique In addition to the PIC line catheter, a simple peripheral catheter will be inserted into the other arm for drug administration. Throughout the study period, mean-skin temperature will be maintained at 31°C by adjusting the temperature of circulating water (Cincinnati Sub-Zero, Cincinnati, OH) and forced-air warmers (Augustine Medical, Inc., Eden Prairie, MN). Furthermore, the back, upper-body, and lower-body will individually be maintained at the designated skin temperature. Lactated Ringer's solution cooled to ≈3°C will be infused via the PIC-line at rates sufficient to decrease tympanic membrane temperature ≈1.5°C/h. Fluid will be administered as long as oxygen consumption or electromyographic intensity (see below) continues to increase or a total of 5 liters of fluid is given. Heart rate will be measured continuously using an electrocardiogram; blood pressure will be determined oscillometrically at 5 min intervals at the ankle. In case heart rate and/or blood pressure changes unexpectedly (by more than 30% of the baseline), the study will stop and the volunteer will be re-warmed immediately.
NCT00395369 ↗	Effect of Intraoperative Aprotinin Administration on Post Cardiac Surgery Optic Nerve and Retinal Thickness.	Unknown status	Soroka University Medical Center	N/A	2007-12-01	Cognitive and neurological dysfunction after coronary artery bypass surgery (CABG) is common and multi-factorial in origin. Several previous studies have shown that intraoperative aprotinin administration may be neuroprotective.in the current prospective randomized study, the effect of intraoperative aprotinin administration on the integrity of the optic nerve and retinal nerve fiber layer will be examined. Optical coherance tomography will be used to examin the optic nerve and retinal nerve fiber layer.
NCT00431743 ↗	Fluid Infusion During Breast Surgery	Unknown status	Rigshospitalet, Denmark	Phase 4	2009-04-01	The investigators want to investigate the effects of two different kinds of fluid infusions given during varicose vein surgery. Both types of fluid are regularly given during surgery, and the investigators want to compare their respective effects on balance, nausea/vomiting and orthostatic function after surgery. The investigators' hypothesis is that using a colloid solution will improve orthostatic function, balance, nausea/vomiting and reduce hospital stay.

Clinical Trial Conditions for Potassium Chloride 30meq In Dextrose 5% And Lactated Ringer's In Plastic Container

Condition Name

Condition Name for Potassium Chloride 30meq In Dextrose 5% And Lactated Ringer's In Plastic Container
Intervention	Trials
Anesthesia	5
Post-ERCP Acute Pancreatitis	4
Cesarean Section	4
Hypotension	4

Condition MeSH

Condition MeSH for Potassium Chloride 30meq In Dextrose 5% And Lactated Ringer's In Plastic Container
Intervention	Trials
Hypotension	16
Pancreatitis	11
Hemorrhage	10
Pain, Postoperative	8

Clinical Trial Locations for Potassium Chloride 30meq In Dextrose 5% And Lactated Ringer's In Plastic Container

Trials by Country

Trials by Country for Potassium Chloride 30meq In Dextrose 5% And Lactated Ringer's In Plastic Container
Location	Trials
Egypt	37
United States	33
China	12
Korea, Republic of	5
Saudi Arabia	4

Trials by US State

Trials by US State for Potassium Chloride 30meq In Dextrose 5% And Lactated Ringer's In Plastic Container
Location	Trials
Illinois	4
Pennsylvania	3
Connecticut	3
California	3
Minnesota	2

Clinical Trial Progress for Potassium Chloride 30meq In Dextrose 5% And Lactated Ringer's In Plastic Container

Clinical Trial Phase

Clinical Trial Phase for Potassium Chloride 30meq In Dextrose 5% And Lactated Ringer's In Plastic Container
Clinical Trial Phase	Trials
Phase 4	39
Phase 3	14
Phase 2/Phase 3	4

Clinical Trial Status

Clinical Trial Status for Potassium Chloride 30meq In Dextrose 5% And Lactated Ringer's In Plastic Container
Clinical Trial Phase	Trials
Completed	64
Not yet recruiting	29
Recruiting	26

Clinical Trial Sponsors for Potassium Chloride 30meq In Dextrose 5% And Lactated Ringer's In Plastic Container

Sponsor Name

Sponsor Name for Potassium Chloride 30meq In Dextrose 5% And Lactated Ringer's In Plastic Container
Sponsor	Trials
Ain Shams University	9
Cairo University	6
Kasr El Aini Hospital	5

Sponsor Type

Sponsor Type for Potassium Chloride 30meq In Dextrose 5% And Lactated Ringer's In Plastic Container
Sponsor	Trials
Other	214
Industry	17
NIH	2

Potassium Chloride 30meq in Dextrose 5% and Lactated Ringer's: Clinical Trials, Market Analysis, and Projections

Clinical Trials and Medical Use

Blood Pressure Management

Clinical trials have explored the potential of potassium chloride in managing blood pressure. A notable study involved 101 adults with mild hypertension, where participants were given 120 mEq/day of potassium chloride or a placebo. The results showed a decrease in systolic blood pressure by 6.4 mm Hg and diastolic blood pressure by 4.1 mm Hg in the potassium-treated group, although the differences were not statistically significant after adjusting for baseline variations[1].

Intravenous Administration

Potassium chloride is also used in intravenous solutions, such as in Lactated Ringer’s and 5% Dextrose Injection. This solution is indicated for fluid and electrolyte replenishment and caloric supply. It contains potassium chloride, which helps in inducing diuresis and has a metabolic alkalinizing effect. However, it is crucial to monitor serum potassium levels, especially in patients treated with other products that can cause hyperkalemia[3].

Market Analysis

Global Market Size and Growth

The global potassium chloride market is projected to grow significantly over the next decade. In 2023, the market is estimated to be valued at approximately $13,084.0 million, with a projected valuation of $18,102.7 million by 2033, growing at a CAGR of 3.3%[2].

Key Industries and Applications

Potassium chloride is a versatile compound with various applications:

• Agriculture: It is widely used as a fertilizer (potash) to promote healthy crop growth and increase yields.
• Food Processing: It serves as a salt substitute, particularly for individuals concerned about sodium intake.
• Water Treatment: It is used as a coagulant to remove impurities and improve water quality.
• Pharmaceuticals: It is an essential component in various intravenous solutions for electrolyte replenishment[2][5].

Regional Market Dynamics

The United States and China are expected to be the dominant markets for potassium chloride. The U.S. market holds a significant share in North America, driven by its use in agriculture, pharmaceuticals, and food processing. China’s industrial expansion, particularly in water treatment, food processing, and agriculture, is also expected to drive demand[2].

Market Projections

Future Growth Drivers

Several factors are expected to drive the growth of the potassium chloride market:

• Agricultural Demand: The increasing global population and the need for higher food production will drive the demand for potassium chloride as a fertilizer.
• Industrial Expansion: China’s focus on expanding its industrial sectors, including water treatment and food processing, will create lucrative opportunities for potassium chloride manufacturers.
• Technological Advancements: Advances in technology and the availability of low-cost natural resources will facilitate market growth[2][5].

Competitive Landscape

The market is currently consolidated, with key players holding a significant share. However, it is expected to become more fragmented as emerging players capitalize on the growing opportunities. Key players are anticipated to engage in production facility expansions and acquisitions to maintain their market position[2].

Key Takeaways

• Potassium chloride has shown potential in clinical trials for blood pressure management, although results are mixed.
• The global market for potassium chloride is projected to grow significantly, driven by its use in agriculture, food processing, and pharmaceuticals.
• The United States and China are expected to remain key markets due to their industrial and agricultural needs.
• Technological advancements and the availability of natural resources will support market growth.

FAQs

What are the primary uses of potassium chloride?

Potassium chloride is primarily used as a fertilizer in agriculture, a salt substitute in food processing, and as a coagulant in water treatment. It is also used in intravenous solutions for fluid and electrolyte replenishment.

How does potassium chloride affect blood pressure?

Clinical trials suggest that potassium chloride can lower blood pressure, with decreases in both systolic and diastolic blood pressure observed in treated groups compared to placebo groups.

What is the projected market value of potassium chloride by 2033?

The global potassium chloride market is projected to reach a valuation of approximately $18,102.7 million by 2033, growing at a CAGR of 3.3% from 2023.

Which regions are expected to drive the demand for potassium chloride?

The United States and China are expected to be the dominant regions driving the demand for potassium chloride, due to their significant agricultural, pharmaceutical, and industrial sectors.

What are the potential risks associated with intravenous administration of potassium chloride?

Intravenous administration of potassium chloride can lead to hyperkalemia, especially in patients treated with other products that increase potassium levels. It is crucial to monitor serum potassium concentrations to avoid severe and potentially fatal hyperkalemia[3].

Sources

1. PubMed: "Double-blind, placebo-controlled trial of potassium chloride in the treatment of mild hypertension."
2. Future Market Insights: "Potassium Chloride Market Size, Growth, Trend & Share | 2033"
3. FDA: "Potassium Chloride in Lactated Ringer's and 5% Dextrose Injection, USP"
4. DrugBank: "Sodium chloride: Uses, Interactions, Mechanism of Action"
5. Allied Market Research: "Potassium Chloride Market Revenue, Size | Industry Forecast 2027"