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Generated: March 26, 2019

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CLINICAL TRIALS PROFILE FOR PLERIXAFOR

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Clinical Trials for Plerixafor

Trial ID Title Status Sponsor Phase Summary
NCT00082329 G-CSF and AMD3100 to Mobilize Stem Cells in Healthy Volunteers Completed National Heart, Lung, and Blood Institute (NHLBI) Phase 2 This 12-day study will test whether the combination of G-CSF (granulocyte-colony stimulating factor) and AMD3100 (Mozobil) is more efficient in mobilizing stem cells for collection than the use of G-CSF alone. Traditionally, the growth factor G-CSF has been given to stem cell donors to mobilize, or push, stem cells out of the bone marrow and into the blood circulation for collection for transplantation. Although a sufficient quantity of cells usually can be collected with G-CSF treatment, some donors do not respond well and may require multiple apheresis procedures (see below) to collect enough cells. Studies indicate that G-CSF used together with a drug called AMD3100 may be more effective in mobilizing stem cells for collection than G-CSF alone. The Food and Drug Administration has approved G-CSF for stem cell mobilization. AMD3100 is a new drug that also mobilizes stem cells in large numbers within a few hours. Normal healthy volunteers between 18 and 60 years of age may be eligible for this study.
NCT00082329 G-CSF and AMD3100 to Mobilize Stem Cells in Healthy Volunteers Completed Richard Childs, M.D. Phase 2 This 12-day study will test whether the combination of G-CSF (granulocyte-colony stimulating factor) and AMD3100 (Mozobil) is more efficient in mobilizing stem cells for collection than the use of G-CSF alone. Traditionally, the growth factor G-CSF has been given to stem cell donors to mobilize, or push, stem cells out of the bone marrow and into the blood circulation for collection for transplantation. Although a sufficient quantity of cells usually can be collected with G-CSF treatment, some donors do not respond well and may require multiple apheresis procedures (see below) to collect enough cells. Studies indicate that G-CSF used together with a drug called AMD3100 may be more effective in mobilizing stem cells for collection than G-CSF alone. The Food and Drug Administration has approved G-CSF for stem cell mobilization. AMD3100 is a new drug that also mobilizes stem cells in large numbers within a few hours. Normal healthy volunteers between 18 and 60 years of age may be eligible for this study.
NCT00103610 Mobilization of Stem Cells With AMD3100 (Plerixafor) in Non-Hodgkin's Lymphoma Patients Completed Genzyme, a Sanofi Company Phase 3 The purpose of this study is to determine whether the combination of AMD3100 (plerixafor) and granulocyte colony-stimulating factor (G-CSF or generic name filgrastim) is better than G-CSF alone to mobilize and collect the optimal number of stem cells in non-Hodgkin's lymphoma patients for autologous transplantation.
NCT00103662 Mobilization of Stem Cells With AMD3100 (Plerixafor) in Multiple Myeloma Patients Completed Genzyme, a Sanofi Company Phase 3 The purpose of this study is to determine whether the combination of AMD3100 (plerixafor) and granulocyte colony-stimulating factor (G-CSF, generic name of filgrastim) is better than G-CSF alone to mobilize and collect the optimal number of stem cells in multiple myeloma patients for autologous transplantation.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Plerixafor

Condition Name

Condition Name for Plerixafor
Intervention Trials
Multiple Myeloma 27
Non-Hodgkin's Lymphoma 10
Acute Myeloid Leukemia 9
Lymphoma, Non-Hodgkin 9
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Condition MeSH

Condition MeSH for Plerixafor
Intervention Trials
Multiple Myeloma 35
Lymphoma, Non-Hodgkin 34
Neoplasms, Plasma Cell 29
Lymphoma 28
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Clinical Trial Locations for Plerixafor

Trials by Country

Trials by Country for Plerixafor
Location Trials
United States 196
Canada 11
France 7
United Kingdom 6
Spain 5
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Trials by US State

Trials by US State for Plerixafor
Location Trials
Missouri 20
California 20
New York 14
Texas 11
Maryland 10
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Clinical Trial Progress for Plerixafor

Clinical Trial Phase

Clinical Trial Phase for Plerixafor
Clinical Trial Phase Trials
Phase 4 5
Phase 3 9
Phase 2 44
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Clinical Trial Status

Clinical Trial Status for Plerixafor
Clinical Trial Phase Trials
Completed 50
Recruiting 28
Active, not recruiting 16
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Clinical Trial Sponsors for Plerixafor

Sponsor Name

Sponsor Name for Plerixafor
Sponsor Trials
Genzyme, a Sanofi Company 43
National Cancer Institute (NCI) 14
Washington University School of Medicine 12
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Sponsor Type

Sponsor Type for Plerixafor
Sponsor Trials
Other 138
Industry 67
NIH 22
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