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Last Updated: July 5, 2020

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CLINICAL TRIALS PROFILE FOR PLATINOL

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All Clinical Trials for Platinol

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00002735 SWOG-9451, Combination Chemo & RT For Patients With Stage III/Stage IV Cancer of the Hypopharynx or Tongue Terminated National Cancer Institute (NCI) Phase 2 1996-04-01 RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining more than one chemotherapy drug with radiation therapy may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy and radiation therapy in treating patients with stage III or stage IV cancer of the hypopharynx or tongue.
NCT00002735 SWOG-9451, Combination Chemo & RT For Patients With Stage III/Stage IV Cancer of the Hypopharynx or Tongue Terminated Southwest Oncology Group Phase 2 1996-04-01 RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining more than one chemotherapy drug with radiation therapy may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy and radiation therapy in treating patients with stage III or stage IV cancer of the hypopharynx or tongue.
NCT00002835 Combination Chemotherapy in Treating Patients With Lymphoma Completed National Cancer Institute (NCI) Phase 3 1995-07-01 RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells. PURPOSE: Randomized phase III trial to compare the effectiveness of two regimens of combination chemotherapy in treating patients who have intermediate-grade or immunoblastic lymphoma.
NCT00002835 Combination Chemotherapy in Treating Patients With Lymphoma Completed M.D. Anderson Cancer Center Phase 3 1995-07-01 RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells. PURPOSE: Randomized phase III trial to compare the effectiveness of two regimens of combination chemotherapy in treating patients who have intermediate-grade or immunoblastic lymphoma.
NCT00004063 Cisplatin, Gemcitabine, Interferon Alfa, and Hyperthermia in Treating Patients With Advanced Cancer Unknown status The University of Texas Health Science Center, Houston Phase 1/Phase 2 1999-08-01 RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Interferon alfa may interfere with the growth of cancer cells. Hyperthermia therapy kills tumor cells by heating them to several degrees above body temperature. Combining hyperthermia with chemotherapy and interferon alfa may kill more tumor cells. PURPOSE: This phase I/II trial is studying the side effects of cisplatin, gemcitabine, interferon alfa, and whole-body hyperthermia and how well they work in treating patients with metastatic, recurrent, or refractory cancer.
NCT00004547 Treatment of Peritoneal Cancer With Surgery, Perfused Heated Cisplatin and Chemotherapy Completed National Cancer Institute (NCI) Phase 2 2000-01-01 This study will test the effectiveness of an experimental treatment for peritoneal cancer involving surgical removal of the tumor, perfusion of the abdomen during surgery with a heated solution of the drug cisplatin, and post-surgery combination chemotherapy in the abdomen with fluorouracil (5-FU) and paclitaxel. Patients with certain peritoneal cancer whose tumors are confined to the abdomen may be eligible for this study. Candidates are screened with a medical history and physical examination, including blood tests, electrocardiogram and possibly bone scan, brain magnetic resonance imaging (MRI), and chest, abdomen and pelvic CT scans. Participants undergo surgery to remove as much tumor as possible. Part of the intestines, pancreas, stomach or the entire spleen may also be removed if they are affected. During surgery, after the tumor has been removed, two catheters (thin plastic tubes) are placed in the abdomen. A chemotherapy solution containing the anti-cancer drug cisplatin heated to a temperature of about 108.6 degrees (10 degrees above normal body temperature) is then delivered into the abdomen through one catheter and drained through another. During treatment, a drug called sodium thiosulfate is given through a vein to reduce the risk of side effects of cisplatin, particularly kidney damage. After 90 minutes of bathing the abdomen with this solution, the drug is rinsed from the abdomen and the catheters removed. Another small catheter is then placed and left inside the abdomen with one end coming out through the skin. Seven to 12 days after the operation, the anti-cancer drugs 5-FU and paclitaxel are given through this catheter. After complete recovery from the surgery, the catheter is removed and the patient is discharged from the hospital. Clinic visits are scheduled for periodic follow-up examination, imaging, and tests 3 and 6 months after surgery and every 6 months for up to 5 years as long as the disease does not worsen. Patients whose disease progresses are taken off the study and referred back to their local physician or referred for alternative care or other research studies. Patients are also asked to assess how this therapy affects their general health and well being. This will require filling out two quality-of-life (QOL) questionnaires before surgery and again at each follow-up visit after surgery. Each questionnaire takes about 15 minutes to complete.
NCT00076310 OSI-774/Cisplatin/Taxotere in Head & Neck Squamous Cell Cancer Active, not recruiting Aventis Pharmaceuticals Phase 2 2004-01-01 The goal of this clinical research study is to learn if giving the new drug, Tarceva® (OSI-774), in combination with Platinol® (cisplatin) and Taxotere® (docetaxel) is effective in the treatment of metastatic or recurrent head and neck cancer. The safety of this treatment will also be studied.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Platinol

Condition Name

Condition Name for Platinol
Intervention Trials
Stage IIIA Bladder Cancer AJCC v8 4
Stage IIIA Lung Cancer AJCC v8 4
Stage III Bladder Cancer AJCC v8 4
Non-Small Cell Lung Cancer 3
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Condition MeSH

Condition MeSH for Platinol
Intervention Trials
Carcinoma 23
Lung Neoplasms 17
Carcinoma, Non-Small-Cell Lung 11
Urinary Bladder Neoplasms 11
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Clinical Trial Locations for Platinol

Trials by Country

Trials by Country for Platinol
Location Trials
United States 107
Argentina 5
Belgium 3
China 2
Korea, Republic of 1
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Trials by US State

Trials by US State for Platinol
Location Trials
Texas 15
California 9
Pennsylvania 7
Minnesota 6
New York 6
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Clinical Trial Progress for Platinol

Clinical Trial Phase

Clinical Trial Phase for Platinol
Clinical Trial Phase Trials
Phase 3 14
Phase 2/Phase 3 5
Phase 2 33
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Clinical Trial Status

Clinical Trial Status for Platinol
Clinical Trial Phase Trials
Not yet recruiting 40
Recruiting 15
Completed 11
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Clinical Trial Sponsors for Platinol

Sponsor Name

Sponsor Name for Platinol
Sponsor Trials
National Cancer Institute (NCI) 39
M.D. Anderson Cancer Center 10
Bristol-Myers Squibb 5
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Sponsor Type

Sponsor Type for Platinol
Sponsor Trials
Other 68
NIH 40
Industry 26
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