Prevention of Infection in Patients With Hematologic Cancer and Persistent Fever Caused by a Low White Blood Cell Count
European Organisation for Research and Treatment of Cancer - EORTC
RATIONALE: Antibiotic therapy may prevent the development of infection in patients with
hematologic cancer and the persistent fever caused by a low white blood cell count. It is
not yet known which regimen of antibiotics is most effective in preventing infection in
PURPOSE: Randomized phase III trial to study the effectiveness of piperacillin-tazobactam
with or without vancomycin in reducing fever in patients who have leukemia, lymphoma, or
Study Comparing the Safety and Efficacy of Piperacillin/Tazobactam to Cefepime in Patients With Hematologic Malignancy or Lymphoma
Wyeth is now a wholly owned subsidiary of Pfizer
To compare the safety and efficacy of piperacillin/tazobactam (4 g/500 mg) administered
intravenously every 6 hours to cefepime (2 g) administered intravenously every 8 hours for
the empiric treatment of neutropenic fever in patients with a hematologic malignancy or
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