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Generated: December 9, 2018

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CLINICAL TRIALS PROFILE FOR PILOCARPINE

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Clinical Trials for Pilocarpine

Trial ID Title Status Sponsor Phase Summary
NCT00003139 Pilocarpine in Preventing Mucositis and Dry Mouth in Patients Receiving Radiation Therapy for Head and Neck Cancer Completed National Cancer Institute (NCI) Phase 3 RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs such as pilocarpine may protect normal cells from the side effects of radiation therapy. It is not yet known if pilocarpine may be effective in preventing mucositis and dry mouth in patients receiving radiation therapy for head and neck cancer. PURPOSE: Randomized, double-blinded, phase III trial to study the effectiveness of pilocarpine in preventing mucositis and dry mouth in patients receiving radiation therapy for head and neck cancer.
NCT00003139 Pilocarpine in Preventing Mucositis and Dry Mouth in Patients Receiving Radiation Therapy for Head and Neck Cancer Completed Radiation Therapy Oncology Group Phase 3 RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs such as pilocarpine may protect normal cells from the side effects of radiation therapy. It is not yet known if pilocarpine may be effective in preventing mucositis and dry mouth in patients receiving radiation therapy for head and neck cancer. PURPOSE: Randomized, double-blinded, phase III trial to study the effectiveness of pilocarpine in preventing mucositis and dry mouth in patients receiving radiation therapy for head and neck cancer.
NCT00003686 Pilocarpine in Treating Patients With Dry Mouth Caused by Opioids Terminated NCIC Clinical Trials Group Phase 3 RATIONALE: Pilocarpine may help to relieve dry mouth in patients receiving opioids for cancer therapy. It is not yet known whether pilocarpine is more effective than no further treatment for this condition. PURPOSE: Randomized phase III trial to determine the effectiveness of pilocarpine in treating patients who have dry mouth caused by opioids.
NCT00168181 Trial Comparing Oral Pilocarpine (Salagen) Versus Submandibular Salivary Gland Transfer Protocol, For the Prevention of Radiation (XRT) Induced Xerostomia in Head and Neck Cancer Patients Completed CancerCare Manitoba Phase 3 This is a study to see whether the drug Salagen or salivary gland transfer is better for the prevention of dryness of the mouth in patients with head and neck cancer receiving radiation treatment.
NCT00168181 Trial Comparing Oral Pilocarpine (Salagen) Versus Submandibular Salivary Gland Transfer Protocol, For the Prevention of Radiation (XRT) Induced Xerostomia in Head and Neck Cancer Patients Completed Jewish General Hospital Phase 3 This is a study to see whether the drug Salagen or salivary gland transfer is better for the prevention of dryness of the mouth in patients with head and neck cancer receiving radiation treatment.
NCT00168181 Trial Comparing Oral Pilocarpine (Salagen) Versus Submandibular Salivary Gland Transfer Protocol, For the Prevention of Radiation (XRT) Induced Xerostomia in Head and Neck Cancer Patients Completed Newfoundland Cancer Treatment & Research Foundation Phase 3 This is a study to see whether the drug Salagen or salivary gland transfer is better for the prevention of dryness of the mouth in patients with head and neck cancer receiving radiation treatment.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Pilocarpine

Condition Name

Condition Name for Pilocarpine
Intervention Trials
Dry Mouth 5
Xerostomia 4
Glaucoma 3
Head and Neck Cancer 3
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Condition MeSH

Condition MeSH for Pilocarpine
Intervention Trials
Xerostomia 6
Glaucoma 4
Head and Neck Neoplasms 3
Ocular Hypertension 2
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Clinical Trial Locations for Pilocarpine

Trials by Country

Trials by Country for Pilocarpine
Location Trials
United States 87
Canada 11
Korea, Republic of 2
United Kingdom 2
Germany 2
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Trials by US State

Trials by US State for Pilocarpine
Location Trials
Texas 6
California 4
Colorado 4
Missouri 3
Indiana 3
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Clinical Trial Progress for Pilocarpine

Clinical Trial Phase

Clinical Trial Phase for Pilocarpine
Clinical Trial Phase Trials
Phase 4 4
Phase 3 5
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for Pilocarpine
Clinical Trial Phase Trials
Completed 16
Recruiting 9
Unknown status 1
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Clinical Trial Sponsors for Pilocarpine

Sponsor Name

Sponsor Name for Pilocarpine
Sponsor Trials
Roxane Laboratories 4
National Cancer Institute (NCI) 3
Radiation Therapy Oncology Group 2
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Sponsor Type

Sponsor Type for Pilocarpine
Sponsor Trials
Other 37
Industry 10
NIH 4
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Serving hundreds of leading biopharmaceutical companies globally:

US Army
Farmers Insurance
Cantor Fitzgerald
UBS
Chubb
Teva
Julphar
Federal Trade Commission
Dow

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