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Generated: February 20, 2019

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CLINICAL TRIALS PROFILE FOR PHENOXYBENZAMINE HYDROCHLORIDE

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Clinical Trials for Phenoxybenzamine Hydrochloride

Trial ID Title Status Sponsor Phase Summary
NCT00569855 Intravenous Phenoxybenzamine Use in Pediatric Patients Undergoing Open-Heart Surgery Completed Arkansas Children's Hospital Research Institute Phase 2 Cardiopulmonary bypass is done with a machine that does the work of the heart and lungs during open-heart surgery. This study is to determine if intravenous (i.v.) phenoxybenzamine is safe. This drug lowers the blood pressure, making it easier for the cardiopulmonary bypass machine to deliver blood and oxygen to all of the organs and tissues.
NCT00569855 Intravenous Phenoxybenzamine Use in Pediatric Patients Undergoing Open-Heart Surgery Completed University of Arkansas Phase 2 Cardiopulmonary bypass is done with a machine that does the work of the heart and lungs during open-heart surgery. This study is to determine if intravenous (i.v.) phenoxybenzamine is safe. This drug lowers the blood pressure, making it easier for the cardiopulmonary bypass machine to deliver blood and oxygen to all of the organs and tissues.
NCT00590018 Corticosteroids in Postoperative Critically Ill Neonates With Low Cardiac Output Syndrome With Congenital Heart Disease Completed Baylor College of Medicine Phase 2 Babies having heart surgery often have problems after surgery with their blood pressure and getting enough blood to their bodies. To treat this they require medicines to keep their blood pressure high enough to get blood to their bodies. The side effects of these medicines include fast heart rates and increasing the amount of work the heart has to do. Corticosteroids are made by the body and help to use the energy in the food people eat, control the chemicals in their blood and maintain their blood pressure. Corticosteroids made by the body may be decreased in patients that have major surgery. Corticosteroids help to increase blood pressure and can decrease the amount of blood pressure medicines a patient requires. Corticosteroids have been shown to increase blood pressure in patients with bacterial infections and in very small, premature babies but have only been studied in a few babies who have had heart surgery. The way corticosteroids work is unknown but may involve decreasing the body's response to being on a heart-lung machine or give steroids not being made by the patient. Corticosteroids have been shown to be helpful in treating many diseases. The purpose of this study is to look at the effects of corticosteroids in babies who have had heart surgery and need blood pressure medicines in the intensive care unit after surgery. Our idea is that getting corticosteroids will allow us to decrease the amount of blood pressure medicines each patient needs and improve how they do after surgery. We also plan to do blood tests to help determine how the corticosteroids are working. It will be randomly determined if the subject receives corticosteroids or salt water. The subject will receive a corticosteroid or salt water once a day for five days. Their vital signs will be monitored, especially blood pressure and their need for medicines to increase their blood pressure. Blood work will also be obtained to determine their body's ability to make steroids.
NCT00620945 Use of Phenoxybenzamine [PBZ] IV to Assist High Flow Low Pressure Perfusion [HFLPP] on Cardio-Pulmonary Bypass Unknown status The Cleveland Clinic N/A Cardiopulmonary bypass [CPB] in small size bodies can result in decreased peripheral perfusion. This results in anaerobic metabolism as evidenced by lactic acidosis. High flow perfusion results in systemic hypertension which is accentuated by moderate hypothermia commonly used during cardiopulmonary bypass. Phenoxybenzamine [PBZ] is an arteriolar vasodilator that acts by irreversibly blocking the alpha adrenergic receptors. It causes vasodilatation allowing high flow, low pressure CPB. It has been used extensively outside US in Canada, Europe and Australia. In the US oral PBZ is FDA approved, whereas intravenous PBZ is only available as an investigational drug
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Phenoxybenzamine Hydrochloride

Condition Name

Condition Name for Phenoxybenzamine Hydrochloride
Intervention Trials
Cardiopulmonary Bypass 2
Pheochromocytoma 2
Paraganglioma 1
Open-heart Surgery 1
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Condition MeSH

Condition MeSH for Phenoxybenzamine Hydrochloride
Intervention Trials
Pheochromocytoma 2
Heart Diseases 2
Heart Defects, Congenital 2
Critical Illness 1
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Clinical Trial Locations for Phenoxybenzamine Hydrochloride

Trials by Country

Trials by Country for Phenoxybenzamine Hydrochloride
Location Trials
United States 5
Netherlands 1
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Trials by US State

Trials by US State for Phenoxybenzamine Hydrochloride
Location Trials
California 1
Tennessee 1
Ohio 1
Texas 1
Arkansas 1
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Clinical Trial Progress for Phenoxybenzamine Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Phenoxybenzamine Hydrochloride
Clinical Trial Phase Trials
Phase 4 1
Phase 3 1
Phase 2 3
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Clinical Trial Status

Clinical Trial Status for Phenoxybenzamine Hydrochloride
Clinical Trial Phase Trials
Recruiting 2
Unknown status 2
Completed 2
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Clinical Trial Sponsors for Phenoxybenzamine Hydrochloride

Sponsor Name

Sponsor Name for Phenoxybenzamine Hydrochloride
Sponsor Trials
UMC Utrecht 1
Vanderbilt University Medical Center 1
Leiden University Medical Center 1
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Sponsor Type

Sponsor Type for Phenoxybenzamine Hydrochloride
Sponsor Trials
Other 21
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Serving hundreds of leading biopharmaceutical companies globally:

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