This study will be an open, non-randomised, clinical phase 2 trial, which will involve 30
women diagnosed with uterine papillary serous cancer. The researchers will investigate the
effect of four cycles of paclitaxel/carboplatin, followed by whole pelvic external beam
radiotherapy to a standard pelvis field (50.4 Gy) with or without a para-aortic boost with
respect to the safety and efficacy of treatment, and patterns of recurrence.
The purpose of this study is to examine the effectiveness of Misoprostol (Cytotec; GD Searle
and Co., Chicago, IL) for the management of non-viable first trimester pregnancies.
Specifically, Misoprostol (15-S-15-methyl PGE1) will be compared to a placebo with expectant
management in who have documented non-viable gestations. We will examine the following
outcome variables: time to resolution, number of patients requiring dilation and curettage,
change in hematocrit, cost to the institution, patient satisfaction, and reported side
We are doing this study to find out if extra medicine is needed to avoid the chance of
nausea sometimes linked to narcotic pain medicine (for example, morphine, dilaudid,
fentanyl). Some doctors always give medicine to prevent the possible side effect of nausea,
while others do not. We are looking to see if this extra medicine is helpful in preventing
nausea. The goal is to screen all patients with pain and enroll enough subjects to reach our
goal of 164 evaluable study participants.
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