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Last Updated: June 21, 2024

CLINICAL TRIALS PROFILE FOR PENTOXIFYLLINE


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505(b)(2) Clinical Trials for Pentoxifylline

This table shows clinical trials for potential 505(b)(2) applications. See the next table for all clinical trials
Trial Type Trial ID Title Status Sponsor Phase Start Date Summary
New Indication NCT05387187 ↗ Evaluate the Effect and Safety of Pu Yang Wan Wu Tang and Western Medicine on Chronic Kidney Disease Not yet recruiting Taipei Medical University Hospital Phase 2/Phase 3 2022-06-01 The indication of Pu Yang Wan Wu Tang is stroke sequelae, such as half body paralysis, aphasia and muscle weakness. Pu Yang Wan Wu Tang is proved to have the effect of protecting nerve and blood vessel, anti-inflammation, anti-coagulation, dilating peripheral vessel, promot-ing micro circulation, improving hemodynamics, and activating central nerve system. Huangqi could attenuate podocyte injury by regulating the expression and distribu-tion of nephrin and podocin. Huangqi and Danggui are associated with fewer infiltra-tion of macrophages and limitation of renal intrinsic cell activation, which may lead to earlier and persistent reduction of proteinuria. This research will use the compound Chinese medicine, Pu Yang Wan Wu Tang. Those treatments combined Western medicine to assess the efficacy and drug safety on the CKD cases. Series of blood and urine were collected regularly during study to prove the role of Chinese medicine in the treatment of CKD, and to assess their drug safety. The final goal of the plan is to establish the new indication of Pu Yang Wan Wu Tang and enhance the interaction and cooperation between Chinese and Western medicine.
>Trial Type >Trial ID >Title >Status >Phase >Start Date >Summary

All Clinical Trials for Pentoxifylline

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00000579 ↗ Acute Respiratory Distress Syndrome Clinical Network (ARDSNet) Completed National Heart, Lung, and Blood Institute (NHLBI) Phase 3 1994-09-01 The purposes of this study are to assess rapidly innovative treatment methods in patients with adult respiratory distress syndrome (ARDS) as well as those at risk of developing ARDS and to create a network of interactive Critical Care Treatment Groups (CCTGs) to establish and maintain the required infrastructure to perform multiple therapeutic trials that may involve investigational drugs, approved agents not currently used for treatment of ARDS, or treatments currently used but whose efficacy has not been well documented.
NCT00000646 ↗ Pentoxifylline (Trental) as a Modulator of Tumor Necrosis Factor and of HIV Replication in Patients With AIDS Completed Hoechst Marion Roussel Phase 1 1969-12-31 To determine whether pentoxifylline lowers tumor necrosis factor (TNF) levels in AIDS patients. Pentoxifylline decreases tumor necrosis factor (TNF), and therefore should decrease such TNF-intensified events as cachexia, enhanced HIV expression, and inhibition of zidovudine (AZT) activity.
NCT00000646 ↗ Pentoxifylline (Trental) as a Modulator of Tumor Necrosis Factor and of HIV Replication in Patients With AIDS Completed National Institute of Allergy and Infectious Diseases (NIAID) Phase 1 1969-12-31 To determine whether pentoxifylline lowers tumor necrosis factor (TNF) levels in AIDS patients. Pentoxifylline decreases tumor necrosis factor (TNF), and therefore should decrease such TNF-intensified events as cachexia, enhanced HIV expression, and inhibition of zidovudine (AZT) activity.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Pentoxifylline

Condition Name

Condition Name for Pentoxifylline
Intervention Trials
Alcoholic Hepatitis 7
Fibrosis 4
HIV Infections 4
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Condition MeSH

Condition MeSH for Pentoxifylline
Intervention Trials
Kidney Diseases 14
Syndrome 11
Hepatitis 10
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Clinical Trial Locations for Pentoxifylline

Trials by Country

Trials by Country for Pentoxifylline
Location Trials
United States 87
Egypt 21
Mexico 8
India 7
Canada 7
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Trials by US State

Trials by US State for Pentoxifylline
Location Trials
Texas 8
Ohio 7
Minnesota 6
Illinois 5
California 5
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Clinical Trial Progress for Pentoxifylline

Clinical Trial Phase

Clinical Trial Phase for Pentoxifylline
Clinical Trial Phase Trials
Phase 4 24
Phase 3 27
Phase 2/Phase 3 12
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Clinical Trial Status

Clinical Trial Status for Pentoxifylline
Clinical Trial Phase Trials
Completed 63
Unknown status 25
Recruiting 24
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Clinical Trial Sponsors for Pentoxifylline

Sponsor Name

Sponsor Name for Pentoxifylline
Sponsor Trials
Tanta University 9
Ain Shams University 5
National Taiwan University Hospital 5
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Sponsor Type

Sponsor Type for Pentoxifylline
Sponsor Trials
Other 207
NIH 18
Industry 13
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