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Generated: December 11, 2018

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CLINICAL TRIALS PROFILE FOR PENTOBARBITAL

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Clinical Trials for Pentobarbital

Trial ID Title Status Sponsor Phase Summary
NCT00123578 GHB Withdrawal Symptoms and Effectiveness of Treatment With Lorazepam Versus Pentobarbital - 1 Withdrawn National Institute on Drug Abuse (NIDA) Phase 1/Phase 2 Gamma hydroxybutyrate (GHB) is a powerful central nervous system depressant. The number of individuals seeking treatment for GHB abuse has been steadily increasing in the United States. Currently, lorazepam and pentobarbital are two medications used to treat individuals who experience GHB-withdrawal symptoms. The purpose of this study is to describe the signs and symptoms of GHB withdrawal and to identify predictors of withdrawal severity. The study will also evaluate the safety and effectiveness of treatment with lorazepam versus pentobarbital for GHB detoxification.
NCT00123578 GHB Withdrawal Symptoms and Effectiveness of Treatment With Lorazepam Versus Pentobarbital - 1 Withdrawn University of California, Los Angeles Phase 1/Phase 2 Gamma hydroxybutyrate (GHB) is a powerful central nervous system depressant. The number of individuals seeking treatment for GHB abuse has been steadily increasing in the United States. Currently, lorazepam and pentobarbital are two medications used to treat individuals who experience GHB-withdrawal symptoms. The purpose of this study is to describe the signs and symptoms of GHB withdrawal and to identify predictors of withdrawal severity. The study will also evaluate the safety and effectiveness of treatment with lorazepam versus pentobarbital for GHB detoxification.
NCT00513240 Erythropoetin Neuroprotection for Neonatal Cardiac Surgery Active, not recruiting Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Phase 1/Phase 2 Brain problems occur in neonatal open heart surgery with a frequency of 20-70%, seen on neurological examination, brain imaging such as magnetic resonance imaging (MRI), or long term development problems such as learning disorders and hyperactivity syndromes. This study aims to determine if erythropoetin, a natural hormone made in the body, protects the brain from damage when given in high doses before and during neonatal open heart surgery. We will use brain MRI, brain wave tests (EEG), neurological examination, and long term developmental outcome testing to see if erythropoetin is better than salt water injection (placebo) in protecting the brain.
NCT00513240 Erythropoetin Neuroprotection for Neonatal Cardiac Surgery Active, not recruiting Texas Children's Hospital Phase 1/Phase 2 Brain problems occur in neonatal open heart surgery with a frequency of 20-70%, seen on neurological examination, brain imaging such as magnetic resonance imaging (MRI), or long term development problems such as learning disorders and hyperactivity syndromes. This study aims to determine if erythropoetin, a natural hormone made in the body, protects the brain from damage when given in high doses before and during neonatal open heart surgery. We will use brain MRI, brain wave tests (EEG), neurological examination, and long term developmental outcome testing to see if erythropoetin is better than salt water injection (placebo) in protecting the brain.
NCT00513240 Erythropoetin Neuroprotection for Neonatal Cardiac Surgery Active, not recruiting The Dana Foundation Phase 1/Phase 2 Brain problems occur in neonatal open heart surgery with a frequency of 20-70%, seen on neurological examination, brain imaging such as magnetic resonance imaging (MRI), or long term development problems such as learning disorders and hyperactivity syndromes. This study aims to determine if erythropoetin, a natural hormone made in the body, protects the brain from damage when given in high doses before and during neonatal open heart surgery. We will use brain MRI, brain wave tests (EEG), neurological examination, and long term developmental outcome testing to see if erythropoetin is better than salt water injection (placebo) in protecting the brain.
NCT00513240 Erythropoetin Neuroprotection for Neonatal Cardiac Surgery Active, not recruiting Baylor College of Medicine Phase 1/Phase 2 Brain problems occur in neonatal open heart surgery with a frequency of 20-70%, seen on neurological examination, brain imaging such as magnetic resonance imaging (MRI), or long term development problems such as learning disorders and hyperactivity syndromes. This study aims to determine if erythropoetin, a natural hormone made in the body, protects the brain from damage when given in high doses before and during neonatal open heart surgery. We will use brain MRI, brain wave tests (EEG), neurological examination, and long term developmental outcome testing to see if erythropoetin is better than salt water injection (placebo) in protecting the brain.
NCT00622570 Comparison of Effectiveness of Pentobarbital and Thiopental in Patients With Refractory Intracranial Hypertension Terminated Fondo de Investigacion Sanitaria Phase 3 Objective: to assess the effectiveness of pentobarbital and thiopental to control raised intracranial pressure (ICP), refractory to first level measures, in patients with severe traumatic brain injury. Material and methods: prospective, randomized open study to compare the effectiveness between two treatments: pentobarbital and thiopental. The patients will be selected from those admitted to the Intensive Care Unit with a severe traumatic brain injury (postresuscitation Glasgow Coma Scale equal or less than 8 points) and raised ICP (ICP>20 mmHg) refractory to first level measures according to the Brain Trauma Foundation guidelines. The adverse effects of both treatments were also collected.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Pentobarbital

Condition Name

Condition Name for Pentobarbital
Intervention Trials
Airway Complication of Anaesthesia 1
Hypoplastic Left Heart Syndrome 1
Heart Disease 1
Healthy 1
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Condition MeSH

Condition MeSH for Pentobarbital
Intervention Trials
Heart Diseases 2
Brain Injuries 1
Transposition of Great Vessels 1
Hypoplastic Left Heart Syndrome 1
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Clinical Trial Locations for Pentobarbital

Trials by Country

Trials by Country for Pentobarbital
Location Trials
United States 5
Spain 1
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Trials by US State

Trials by US State for Pentobarbital
Location Trials
Ohio 1
Massachusetts 1
Missouri 1
Texas 1
California 1
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Clinical Trial Progress for Pentobarbital

Clinical Trial Phase

Clinical Trial Phase for Pentobarbital
Clinical Trial Phase Trials
Phase 4 1
Phase 3 1
Phase 2 1
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Clinical Trial Status

Clinical Trial Status for Pentobarbital
Clinical Trial Phase Trials
Withdrawn 3
Active, not recruiting 1
Completed 1
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Clinical Trial Sponsors for Pentobarbital

Sponsor Name

Sponsor Name for Pentobarbital
Sponsor Trials
Baylor College of Medicine 1
Children's Hospital Medical Center, Cincinnati 1
The Dana Foundation 1
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Sponsor Type

Sponsor Type for Pentobarbital
Sponsor Trials
Other 10
NIH 2
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Serving hundreds of leading biopharmaceutical companies globally:

McKinsey
Teva
US Department of Justice
Medtronic
Daiichi Sankyo
Covington
QuintilesIMS
Colorcon
Accenture

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