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Generated: February 15, 2019

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CLINICAL TRIALS PROFILE FOR PAZOPANIB HYDROCHLORIDE

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Clinical Trials for Pazopanib Hydrochloride

Trial ID Title Status Sponsor Phase Summary
NCT00244764 GW786034 In Subjects With Locally Recurrent Or Metastatic Clear Cell Renal Cell Carcinoma Completed GlaxoSmithKline Phase 2 Phase II, multi-center, two-stage study utilising a randomised discontinuation design to evaluate the safety and efficacy of GW786034 (pazopanib) in adult subjects with locally recurrent or metastatic clear-cell Renal Cell Carcinoma (RCC). After the interim analysis, the design was changed to an open label, single arm study with all subjects receiving pazopanib.
NCT00256880 Pazopanib (GW786034) In Subjects With Relapsed Or Refractory Multiple Myeloma Completed GlaxoSmithKline Phase 2 The purpose of this study is to determine how effective and safe a new investigational drug is in treating patients with relapsed or refractory multiple myeloma. The treatment involves daily dosing. A patient may continue to receive the treatment as long as they are benefiting from the treatment. Blood samples will be taken at specific times to measure the amount of drug in your body at specific times after the drug is given. Blood samples will also be taken for lab tests such as complete blood counts and clinical chemistries. Physical exams will be performed before each treatment. During the treatment phase, the patients will undergo regular assessments for safety and clinical response.
NCT00297258 Pazopanib In Patients With Relapsed Or Refractory Soft Tissue Sarcoma Completed GlaxoSmithKline Phase 2 The purpose of this study is to evaluate the activity and tolerability of pazopanib in subjects with advanced and/or metastatic soft tissue sarcoma who have relapsed following standard therapies or for whom no standard therapy exists and to characterize the pharmacokinetics of pazopanib in this subject population.
NCT00334282 Safety and Efficacy of GW786034 (Pazopanib) In Metastatic Renal Cell Carcinoma Completed GlaxoSmithKline Phase 3 To evaluate efficacy and safety of pazopanib compared to placebo in patients with locally advanced and/ or metastatic renal cell carcinoma (RCC). Approximately 350-400 eligible patients will be stratified and randomized in a 2:1 ratio to receive either 800 mg pazopanib once daily or matching placebo. The study treatment will continue until patients experience disease progression, unacceptable toxicity or death. Primary objective of the study is to evaluate and compare the two treatment arms for progression-free survival. Principal secondary objective is to evaluate and compare the two treatment arms with respect to overall survival. Other objectives are overall response rate [complete response (CR) + partial response (PR)], rate of CR + PR + 6 months stable disease, and the incidence, severity and causality of adverse events and serious adverse events. Safety and efficacy assessments will be regularly performed on all patients. An Independent Data Monitoring Committee will be established to monitor safety during the course of the study and to evaluate interim efficacy data on overall survival.
NCT00347919 Pazopanib Plus Lapatinib Compared To Lapatinib Alone In Subjects With Advanced Or Metastatic Breast Cancer Completed GlaxoSmithKline Phase 2 This study is being conducted to compare the efficacy and safety of pazopanib in combination with lapatinib with that of lapatinib alone in subjects with locally advanced or metastatic breast cancer whose tumors overexpress the ErbB2 protein.
NCT00350727 Pazopanib In Combination With Lapatinib In Adult Patients With Relapsed Malignant Glioma Completed GlaxoSmithKline Phase 2 This study is being conducted to characterize the safety/tolerability of pazopanib and lapatinib when administered in combination with enzyme-inducing anticonvulsants in patients with recurrent Grade III or IV malignant gliomas.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Pazopanib Hydrochloride

Condition Name

Condition Name for Pazopanib Hydrochloride
Intervention Trials
Carcinoma, Renal Cell 27
Renal Cell Carcinoma 12
Sarcoma 10
Ovarian Cancer 9
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Condition MeSH

Condition MeSH for Pazopanib Hydrochloride
Intervention Trials
Carcinoma, Renal Cell 76
Carcinoma 68
Sarcoma 40
Carcinoma, Non-Small-Cell Lung 16
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Clinical Trial Locations for Pazopanib Hydrochloride

Trials by Country

Trials by Country for Pazopanib Hydrochloride
Location Trials
United States 896
Germany 105
Italy 74
Canada 66
United Kingdom 43
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Trials by US State

Trials by US State for Pazopanib Hydrochloride
Location Trials
Texas 53
California 52
New York 38
Pennsylvania 36
Ohio 36
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Clinical Trial Progress for Pazopanib Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Pazopanib Hydrochloride
Clinical Trial Phase Trials
Phase 4 8
Phase 3 15
Phase 2/Phase 3 3
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Clinical Trial Status

Clinical Trial Status for Pazopanib Hydrochloride
Clinical Trial Phase Trials
Completed 91
Recruiting 59
Active, not recruiting 48
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Clinical Trial Sponsors for Pazopanib Hydrochloride

Sponsor Name

Sponsor Name for Pazopanib Hydrochloride
Sponsor Trials
GlaxoSmithKline 101
National Cancer Institute (NCI) 42
Novartis 18
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Sponsor Type

Sponsor Type for Pazopanib Hydrochloride
Sponsor Trials
Other 219
Industry 164
NIH 42
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Serving hundreds of leading biopharmaceutical companies globally:

McKesson
Mallinckrodt
Queensland Health
Boehringer Ingelheim
Dow
AstraZeneca
Fuji
Farmers Insurance
Healthtrust

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