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Last Updated: March 29, 2024

CLINICAL TRIALS PROFILE FOR PAZOPANIB HYDROCHLORIDE


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505(b)(2) Clinical Trials for Pazopanib Hydrochloride

This table shows clinical trials for potential 505(b)(2) applications. See the next table for all clinical trials
Trial Type Trial ID Title Status Sponsor Phase Start Date Summary
New Formulation NCT02810756 ↗ Study With Improved Solubility Pazopanib Completed The Netherlands Cancer Institute Early Phase 1 2016-09-15 The pharmacokinetics of a new formulation with Pazopanib will be studied. This will be done in a patient cohort of n = 12.
New Combination NCT03571438 ↗ Evaluation of a Promising New Combination of Protein Kinase Inhibitors on Organotypic Cultures of Human Renal Tumors Recruiting University Hospital, Grenoble N/A 2017-10-16 The investigators objective is to test the combination directly on organotypic cultures of tumors from patients after their excision in the Department of Urology and Renal Transplantation of the University Hospital of Grenoble and to compare their efficacy with that of currently selected treatments in the clinic. The population targeted by the combination for use in clinical practice is patients with metastatic clear cell renal cell carcinoma. Current treatments for these patients are Sunitinib, Pazopanib and Temsirolimus.
>Trial Type >Trial ID >Title >Status >Phase >Start Date >Summary

All Clinical Trials for Pazopanib Hydrochloride

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00244764 ↗ GW786034 In Subjects With Locally Recurrent Or Metastatic Clear Cell Renal Cell Carcinoma Completed GlaxoSmithKline Phase 2 2005-10-01 Phase II, multi-center, two-stage study utilising a randomised discontinuation design to evaluate the safety and efficacy of GW786034 (pazopanib) in adult subjects with locally recurrent or metastatic clear-cell Renal Cell Carcinoma (RCC). After the interim analysis, the design was changed to an open label, single arm study with all subjects receiving pazopanib.
NCT00256880 ↗ Pazopanib (GW786034) In Subjects With Relapsed Or Refractory Multiple Myeloma Completed GlaxoSmithKline Phase 2 2005-01-01 The purpose of this study is to determine how effective and safe a new investigational drug is in treating patients with relapsed or refractory multiple myeloma. The treatment involves daily dosing. A patient may continue to receive the treatment as long as they are benefiting from the treatment. Blood samples will be taken at specific times to measure the amount of drug in your body at specific times after the drug is given. Blood samples will also be taken for lab tests such as complete blood counts and clinical chemistries. Physical exams will be performed before each treatment. During the treatment phase, the patients will undergo regular assessments for safety and clinical response.
NCT00297258 ↗ Pazopanib In Patients With Relapsed Or Refractory Soft Tissue Sarcoma Completed GlaxoSmithKline Phase 2 2005-11-01 The purpose of this study is to evaluate the activity and tolerability of pazopanib in subjects with advanced and/or metastatic soft tissue sarcoma who have relapsed following standard therapies or for whom no standard therapy exists and to characterize the pharmacokinetics of pazopanib in this subject population.
NCT00334282 ↗ Safety and Efficacy of GW786034 (Pazopanib) In Metastatic Renal Cell Carcinoma Completed GlaxoSmithKline Phase 3 2006-04-01 To evaluate efficacy and safety of pazopanib compared to placebo in patients with locally advanced and/ or metastatic renal cell carcinoma (RCC). Approximately 350-400 eligible patients will be stratified and randomized in a 2:1 ratio to receive either 800 mg pazopanib once daily or matching placebo. The study treatment will continue until patients experience disease progression, unacceptable toxicity or death. Primary objective of the study is to evaluate and compare the two treatment arms for progression-free survival. Principal secondary objective is to evaluate and compare the two treatment arms with respect to overall survival. Other objectives are overall response rate [complete response (CR) + partial response (PR)], rate of CR + PR + 6 months stable disease, and the incidence, severity and causality of adverse events and serious adverse events. Safety and efficacy assessments will be regularly performed on all patients. An Independent Data Monitoring Committee will be established to monitor safety during the course of the study and to evaluate interim efficacy data on overall survival.
NCT00347919 ↗ Pazopanib Plus Lapatinib Compared To Lapatinib Alone In Subjects With Advanced Or Metastatic Breast Cancer Completed GlaxoSmithKline Phase 2 2006-07-01 This study is being conducted to compare the efficacy and safety of pazopanib in combination with lapatinib with that of lapatinib alone in subjects with locally advanced or metastatic breast cancer whose tumors overexpress the ErbB2 protein.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Pazopanib Hydrochloride

Condition Name

Condition Name for Pazopanib Hydrochloride
Intervention Trials
Carcinoma, Renal Cell 28
Renal Cell Carcinoma 14
Sarcoma 13
Ovarian Cancer 10
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Condition MeSH

Condition MeSH for Pazopanib Hydrochloride
Intervention Trials
Carcinoma, Renal Cell 79
Carcinoma 73
Sarcoma 47
Neoplasms 25
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Clinical Trial Locations for Pazopanib Hydrochloride

Trials by Country

Trials by Country for Pazopanib Hydrochloride
Location Trials
United States 922
Germany 108
Italy 82
Canada 72
Australia 48
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Trials by US State

Trials by US State for Pazopanib Hydrochloride
Location Trials
Texas 57
California 53
New York 40
Pennsylvania 36
Ohio 36
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Clinical Trial Progress for Pazopanib Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Pazopanib Hydrochloride
Clinical Trial Phase Trials
Phase 4 7
Phase 3 16
Phase 2/Phase 3 6
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Clinical Trial Status

Clinical Trial Status for Pazopanib Hydrochloride
Clinical Trial Phase Trials
Completed 162
Terminated 50
Active, not recruiting 28
[disabled in preview] 25
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Clinical Trial Sponsors for Pazopanib Hydrochloride

Sponsor Name

Sponsor Name for Pazopanib Hydrochloride
Sponsor Trials
GlaxoSmithKline 103
National Cancer Institute (NCI) 46
Novartis 25
[disabled in preview] 27
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Sponsor Type

Sponsor Type for Pazopanib Hydrochloride
Sponsor Trials
Other 264
Industry 188
NIH 46
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