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Generated: February 16, 2019

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CLINICAL TRIALS PROFILE FOR PACLITAXEL

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Clinical Trials for Paclitaxel

Trial ID Title Status Sponsor Phase Summary
NCT00001383 A Phase I Study of Infusional Paclitaxel With the P-Glycoprotein Antagonist PSC 833 Completed National Cancer Institute (NCI) Phase 1 This is a dosage escalation study to estimate the maximum tolerated dose of drug resistance inhibitor PSC 833 given in combination with paclitaxel. Groups of 3 to 6 patients receive continuous-infusion paclitaxel for 5 days and oral PSC 833 for 6-7 days, following paclitaxel on the first course, then beginning 3 days prior to paclitaxel on subsequent courses. Stable and responding patients are re-treated every 21 days, with paclitaxel dose adjusted to maintain an absolute neutrophil count less than 500 for no more than 4 days.
NCT00001384 A Pilot Trial of AC (Adriamycin, Cyclophosphamide) Chemotherapy With G-CSF (Granulocyte Colony-Stimulating Factor) Followed by Infusional Taxol (Paclitaxel) as Adjuvant Treatment for High Risk Stage II and Stage III Breast Cancer Patients Completed National Cancer Institute (NCI) Phase 2 This is a pilot feasibility trial of AC (Adriamycin, cyclophosphamide) chemotherapy with G-CSF (filgrastim) followed by infusional Taxol (paclitaxel) as adjuvant treatment for patients with high risk stage II and stage III breast cancer. Cycles will be 14 days in duration. After 3 fourteen day cycles of AC with filgrastim, patients will be treated with 3 fourteen day cycles of 96 hour infusional paclitaxel. The goal of this study will be to assess the toxicity and feasibility of administering dose-intensive AC chemotherapy followed by infusional paclitaxel in 14 day cycles.
NCT00001387 Phase I and Pharmacokinetic Trial of Paclitaxel (Taxol) Given as a 3-Hour Infusion in Pediatric Patients With Refractory Malignancy Completed National Cancer Institute (NCI) Phase 1 The objective of this trial is to determine the maximum tolerated dose and the toxicities of paclitaxel given as a short hour infusion in children with refractory malignancy.
NCT00001426 A Multi-Institutional Phase II Study of Cyclophosphamide, Paclitaxel, Cisplatin With G-CSF for Patients With Newly Diagnosed Advanced Stage Ovarian Cancer Completed National Cancer Institute (NCI) Phase 2 A supra-additive cytotoxic effect was seen when CAI and paclitaxel were given to human ovarian cancer cells sequentially in tissue culture. We have demonstrated that CAI given for 8 days followed by paclitaxel is reasonably well tolerated and that paclitaxel administration causes a dose-dependent increase in CAI plasma concentration. CAI is a cytostatic drug and continuous exposure is needed. This study will evaluate the combination of continuously administered CAI with three-weekly paclitaxel.
NCT00001427 A Phase II Trial of 72-Hour Continuous IV Infusion of 9-Aminocamptothecin With G-CSF Support in Patients With Advanced Ovarian Cancer Previously Treated With Paclitaxel and Cisplatin Completed National Cancer Institute (NCI) Phase 2 The objectives of this study are to determine the response rate to 9-AC in patients with advanced ovarian cancer who have recurrent disease after paclitaxel- and cisplatin-based chemotherapy regimens.
NCT00001442 A Pilot Study of Paclitaxel With Radiation Therapy for Locally Advanced Head and Neck Cancer Completed National Cancer Institute (NCI) Phase 1 Radiotherapy plus Single-Agent Chemotherapy/Radiosensitization. Irradiation of tumor and involved nodes using 4-6 MV photons (brachytherapy allowed to boost primary tumor; electrons allowed to boost posterior neck and massive adenopathy); plus Paclitaxel (Bristol-Myers), Taxol, TAX, NSC-125973.
NCT00001450 Phase II Trial of a 96-Hour Continuous Infusion of Paclitaxel Followed by Cisplatin for Patients With Stage III/IV and Relapsed NSCLC Completed National Cancer Institute (NCI) Phase 2 This is a Phase II study of paclitaxel (Taxol R) administered as a 96-hour (4 day) continuous infusion followed by a bolus of cisplatin for previously untreated patients with stage III/IV or relapsed non-small cell lung cancer (NSCLC). The goal of this phase II study is to determine the response rate of this infusional paclitaxel and bolus cisplatin regimen in patients with advanced NSCLC.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Paclitaxel

Condition Name

Condition Name for Paclitaxel
Intervention Trials
Breast Cancer 358
Ovarian Cancer 210
Lung Cancer 154
Non-Small Cell Lung Cancer 101
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Condition MeSH

Condition MeSH for Paclitaxel
Intervention Trials
Breast Neoplasms 610
Carcinoma, Non-Small-Cell Lung 428
Lung Neoplasms 427
Ovarian Neoplasms 311
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Clinical Trial Locations for Paclitaxel

Trials by Country

Trials by Country for Paclitaxel
Location Trials
Italy 542
Canada 489
Spain 457
Japan 371
China 343
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Trials by US State

Trials by US State for Paclitaxel
Location Trials
New York 493
California 490
Texas 485
Pennsylvania 423
Ohio 412
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Clinical Trial Progress for Paclitaxel

Clinical Trial Phase

Clinical Trial Phase for Paclitaxel
Clinical Trial Phase Trials
Phase 4 36
Phase 3 412
Phase 2/Phase 3 52
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Clinical Trial Status

Clinical Trial Status for Paclitaxel
Clinical Trial Phase Trials
Completed 958
Recruiting 575
Active, not recruiting 305
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Clinical Trial Sponsors for Paclitaxel

Sponsor Name

Sponsor Name for Paclitaxel
Sponsor Trials
National Cancer Institute (NCI) 583
Celgene Corporation 100
Genentech, Inc. 95
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Sponsor Type

Sponsor Type for Paclitaxel
Sponsor Trials
Other 2419
Industry 1340
NIH 596
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Healthtrust
Colorcon
Queensland Health
Fish and Richardson
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Citi
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UBS

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