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Generated: February 16, 2019

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CLINICAL TRIALS PROFILE FOR OXALIPLATIN

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Clinical Trials for Oxaliplatin

Trial ID Title Status Sponsor Phase Summary
NCT00001835 Oxaliplatin in Cancer Patients With Impaired Kidney Function Completed National Cancer Institute (NCI) Phase 1 Oxaliplatin is an experimental anti-cancer drug that can shrink tumors such as colon cancer. However, because this drug can damage the kidneys, it is necessary to determine what doses of the drug can safely be given to patients with poor kidney function. Patients with advanced cancer, poorly functioning kidneys, and no good standard treatment options are eligible for this study. Candidates will be screened with imaging tests, such as CT and MRI scans, to determine the size and location of the cancer and with blood and urine tests to evaluate kidney and liver function. Study participants will receive oxaliplatin intravenously (through a vein) every 3 weeks for as long as the cancer is under control and there are no serious side effects from the drug. If significant side effects develop, the dosage will be reduced, or the drug will be stopped. Blood tests to measure blood cell counts will be done at least once a week, and CT scans, chest X-rays, and MRIs will be done about once every 6 weeks to assess the tumor's response to the treatment. Additional blood tests will be done at the beginning of the first two treatment cycles to measure the amount of oxaliplatin in the blood, and urine will be collected during the first 24 hours of drug treatment to determine how much drug is eliminated by the body in urine.
NCT00003260 Combination Chemotherapy in Treating Patients With Recurrent Metastatic Colorectal Cancer Unknown status Groupe Cooperateur Multidisciplinaire en Oncologie (GERCOR) Phase 3 RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and giving the drugs in different combinations may kill more tumor cells. It is not yet known whether receiving irinotecan with fluorouracil and leucovorin is more effective than receiving oxaliplatin with fluorouracil and leucovorin in treating recurrent metastatic colorectal cancer PURPOSE: Randomized phase III trial to compare the effectiveness of irinotecan with oxaliplatin followed by fluorouracil and leucovorin in treating patients with recurrent metastatic colorectal cancer.
NCT00003287 Combination Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal Cancer Completed European Organisation for Research and Treatment of Cancer - EORTC Phase 3 RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known which regimen of combination chemotherapy is more effective in treating patients with recurrent or metastatic colorectal cancer. PURPOSE: Randomized phase III trial to study the effectiveness of combining fluorouracil, leucovorin, and oxaliplatin in different ways in treating patients with recurrent or metastatic colorectal cancer.
NCT00003427 Oxaliplatin Plus Irinotecan in Treating Patients With Metastatic Gastrointestinal Cancer Completed National Cancer Institute (NCI) Phase 1 RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of oxaliplatin plus irinotecan in treating patients with previously treated metastatic gastrointestinal cancer that has not responded to previous treatment.
NCT00003427 Oxaliplatin Plus Irinotecan in Treating Patients With Metastatic Gastrointestinal Cancer Completed Memorial Sloan Kettering Cancer Center Phase 1 RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of oxaliplatin plus irinotecan in treating patients with previously treated metastatic gastrointestinal cancer that has not responded to previous treatment.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Oxaliplatin

Condition Name

Condition Name for Oxaliplatin
Intervention Trials
Colorectal Cancer 268
Gastric Cancer 104
Metastatic Colorectal Cancer 93
Pancreatic Cancer 68
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Condition MeSH

Condition MeSH for Oxaliplatin
Intervention Trials
Colorectal Neoplasms 530
Adenocarcinoma 213
Stomach Neoplasms 200
Pancreatic Neoplasms 143
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Clinical Trial Locations for Oxaliplatin

Trials by Country

Trials by Country for Oxaliplatin
Location Trials
Australia 78
Belgium 53
Taiwan 46
Austria 41
Netherlands 39
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Trials by US State

Trials by US State for Oxaliplatin
Location Trials
California 168
New York 148
Texas 126
Ohio 124
Pennsylvania 115
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Clinical Trial Progress for Oxaliplatin

Clinical Trial Phase

Clinical Trial Phase for Oxaliplatin
Clinical Trial Phase Trials
Phase 4 20
Phase 3 227
Phase 2/Phase 3 36
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Clinical Trial Status

Clinical Trial Status for Oxaliplatin
Clinical Trial Phase Trials
Completed 515
Recruiting 330
Unknown status 164
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Clinical Trial Sponsors for Oxaliplatin

Sponsor Name

Sponsor Name for Oxaliplatin
Sponsor Trials
National Cancer Institute (NCI) 219
Sanofi 126
Hoffmann-La Roche 58
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Sponsor Type

Sponsor Type for Oxaliplatin
Sponsor Trials
Other 1468
Industry 638
NIH 220
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Serving hundreds of leading biopharmaceutical companies globally:

Accenture
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Fish and Richardson
Teva
Federal Trade Commission
Moodys
AstraZeneca
Cerilliant
Colorcon

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