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Generated: February 22, 2019

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CLINICAL TRIALS PROFILE FOR OLAPARIB

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Clinical Trials for Olaparib

Trial ID Title Status Sponsor Phase Summary
NCT00494234 Study to Assess the Efficacy and Safety of a PARP Inhibitor for the Treatment of BRCA-positive Advanced Breast Cancer Active, not recruiting KuDOS Pharmaceuticals Limited Phase 2 The purpose of the study is to see if the drug KU 0059436 (olaparib) is effective and well tolerated in treating patients with measurable BRCA1- or BRCA2-positive advanced breast cancer and for whom no curative therapeutic option exists.
NCT00494234 Study to Assess the Efficacy and Safety of a PARP Inhibitor for the Treatment of BRCA-positive Advanced Breast Cancer Active, not recruiting AstraZeneca Phase 2 The purpose of the study is to see if the drug KU 0059436 (olaparib) is effective and well tolerated in treating patients with measurable BRCA1- or BRCA2-positive advanced breast cancer and for whom no curative therapeutic option exists.
NCT00494442 Study to Assess the Efficacy and Safety of a PARP Inhibitor for the Treatment of BRCA-positive Advanced Ovarian Cancer Active, not recruiting KuDOS Pharmaceuticals Limited Phase 2 The purpose of the study is to see if the drug KU 0059436 is effective and well tolerated in treating patients with measurable BRCA1- or BRCA2-positive advanced ovarian cancer and for whom no curative therapeutic option exists.
NCT00494442 Study to Assess the Efficacy and Safety of a PARP Inhibitor for the Treatment of BRCA-positive Advanced Ovarian Cancer Active, not recruiting AstraZeneca Phase 2 The purpose of the study is to see if the drug KU 0059436 is effective and well tolerated in treating patients with measurable BRCA1- or BRCA2-positive advanced ovarian cancer and for whom no curative therapeutic option exists.
NCT00515866 Study to Assess the Safety & Tolerability of a PARP Inhibitor in Combination With Gemcitabine in Pancreatic Cancer Completed AstraZeneca Phase 1 The purpose of this study is to identify a safe and tolerable dose of the drug KU-0059436 that can be given in combination with gemcitabine chemotherapy for the treatment of pancreatic cancer.
NCT00516373 A Study to Assess the Safety and Pharmacokinetics of an Inhibitor of Poly ADP-Ribose Polymerase-1 (PARP) Active, not recruiting AstraZeneca Phase 1 To determine the safety, tolerability, dose-limiting toxicity (DLT), pharmacokinetic-pharmacodynamic profile, and maximum tolerated dose (MTD) of KU-0059436 when administered orally to patients with advanced solid tumours. To further evaluate the safety and efficacy of KU-0059436 in an expanded cohort of BCRA-enriched population, primarily ovarian cancer patients.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Olaparib

Condition Name

Condition Name for Olaparib
Intervention Trials
Ovarian Cancer 18
Breast Cancer 15
Recurrent Fallopian Tube Carcinoma 7
Solid Tumours 7
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Condition MeSH

Condition MeSH for Olaparib
Intervention Trials
Ovarian Neoplasms 41
Breast Neoplasms 31
Carcinoma 27
Neoplasms 19
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Clinical Trial Locations for Olaparib

Trials by Country

Trials by Country for Olaparib
Location Trials
United States 558
Canada 66
United Kingdom 60
Spain 46
Italy 29
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Trials by US State

Trials by US State for Olaparib
Location Trials
California 33
New York 32
Massachusetts 29
Pennsylvania 26
Maryland 25
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Clinical Trial Progress for Olaparib

Clinical Trial Phase

Clinical Trial Phase for Olaparib
Clinical Trial Phase Trials
Phase 4 1
Phase 3 19
Phase 2/Phase 3 2
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Clinical Trial Status

Clinical Trial Status for Olaparib
Clinical Trial Phase Trials
Recruiting 82
Not yet recruiting 58
Active, not recruiting 30
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Clinical Trial Sponsors for Olaparib

Sponsor Name

Sponsor Name for Olaparib
Sponsor Trials
AstraZeneca 114
National Cancer Institute (NCI) 27
Myriad Genetic Laboratories, Inc. 9
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Sponsor Type

Sponsor Type for Olaparib
Sponsor Trials
Industry 169
Other 157
NIH 27
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Serving hundreds of leading biopharmaceutical companies globally:

Accenture
McKinsey
Daiichi Sankyo
Chinese Patent Office
Cantor Fitzgerald
Moodys
Merck
Cipla
Mallinckrodt

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