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Generated: February 20, 2019

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CLINICAL TRIALS PROFILE FOR OFLOXACIN

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Clinical Trials for Ofloxacin

Trial ID Title Status Sponsor Phase Summary
NCT00002249 A Double-Blind Study to Evaluate the Safety and Pharmacokinetics of L-Ofloxacin (RWJ 25213) in Subjects With HIV Infection Completed R W Johnson Pharmaceutical Research Institute Phase 1 To determine the safety and pharmacokinetics of L-ofloxacin (RWJ 25213) in patients with HIV infection.
NCT00002850 Antibiotic Therapy in Preventing Early Infection in Patients With Multiple Myeloma Who Are Receiving Chemotherapy Completed Eastern Cooperative Oncology Group Phase 3 RATIONALE: Giving antibiotics may be effective in preventing or controlling early infection in patients with multiple myeloma and may improve their response to chemotherapy. PURPOSE: This randomized clinical trial is studying antibiotics to see how well they work compared to no antibiotics in preventing early infection in patients with multiple myeloma.
NCT00002850 Antibiotic Therapy in Preventing Early Infection in Patients With Multiple Myeloma Who Are Receiving Chemotherapy Completed National Cancer Institute (NCI) Phase 3 RATIONALE: Giving antibiotics may be effective in preventing or controlling early infection in patients with multiple myeloma and may improve their response to chemotherapy. PURPOSE: This randomized clinical trial is studying antibiotics to see how well they work compared to no antibiotics in preventing early infection in patients with multiple myeloma.
NCT00002850 Antibiotic Therapy in Preventing Early Infection in Patients With Multiple Myeloma Who Are Receiving Chemotherapy Completed Gary Morrow Phase 3 RATIONALE: Giving antibiotics may be effective in preventing or controlling early infection in patients with multiple myeloma and may improve their response to chemotherapy. PURPOSE: This randomized clinical trial is studying antibiotics to see how well they work compared to no antibiotics in preventing early infection in patients with multiple myeloma.
NCT00359970 Azithromycin, With or Without Loperamide, to Treat Travelers' Diarrhea Completed The University of Texas Health Science Center, Houston Phase 4 In a previous study azithromycin proved as efficacious as levofloxacin in the treatment of travelers' diarrhea in Mexico. Because the addition of loperamide to some antibiotics (e.g., trimethoprim-sulfamethoxazole and ofloxacin) has proven more efficacious than antibiotic alone in the treatment of travelers' diarrhea, we decided to study the addition of loperamide to azithromycin. US adults with acute diarrhea in Guadalajara Mexico were randomized to receive azithromycin in two different doses or loperamide plus azithromycin. The duration of diarrhea was shorter (11 hours) in the combination-treated group compared to the antibiotic-treated groups (34 hours). The percentage of subjects continuing to pass 6 or more unformed stools in the first 24 hours was less (1.7%) in the combination-treated group than in the antibiotic-treated groups (20%). We feel loperamide should routinely be added to an antibiotic to optimize treatment of travelers' diarrhea.
NCT00392275 Penetrance of Third Generation Fluoroquinolones in Eyes With Functioning Filtering Blebs Completed Indiana University School of Medicine Phase 4 Based on previous results with eyes without filtering blebs, the aqueous concentrations of ofloxacin and levofloxacin will exceed the concentration of ciprofloxacin after either topical or topical plus oral administration.
NCT00480376 Ofloxacin vs. Gentamicin as Prophylaxis Prior Transrectal Biopsy of Prostate Unknown status HaEmek Medical Center, Israel Phase 4 Prostate biopsy is usually conducted transrectal, ultrasonography guided. Since the area is not sterile, infection can be induced during the procedure. Prophylaxis antibiotic against gram-negative bacteria decreased significantly the amount of infections. Quinolones are considered preferred treatment but there is already an increase in resistance rates. TMP-SMX can not be used empirically due to a high percent of resistant uropathogens. One of the options is aminoglycosides, especially gentamicin. Advantages: very low resistance rate in the community, high concentration is urinary tract, slow clearance, no resistance developed under treatment, chip and with very few side effects.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Ofloxacin

Condition Name

Condition Name for Ofloxacin
Intervention Trials
Pelvic Inflammatory Disease 3
Infection 2
Diabetic Foot Ulcers 2
Primary Bacterial Peritonitis 1
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Condition MeSH

Condition MeSH for Ofloxacin
Intervention Trials
Communicable Diseases 3
Pelvic Inflammatory Disease 3
Pelvic Infection 3
Infection 3
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Clinical Trial Locations for Ofloxacin

Trials by Country

Trials by Country for Ofloxacin
Location Trials
United States 24
United Kingdom 5
South Africa 5
Germany 5
Turkey 3
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Trials by US State

Trials by US State for Ofloxacin
Location Trials
Washington 3
New Jersey 2
Oregon 1
Pennsylvania 1
South Carolina 1
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Clinical Trial Progress for Ofloxacin

Clinical Trial Phase

Clinical Trial Phase for Ofloxacin
Clinical Trial Phase Trials
Phase 4 9
Phase 3 8
Phase 2 3
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Clinical Trial Status

Clinical Trial Status for Ofloxacin
Clinical Trial Phase Trials
Completed 16
Recruiting 5
Not yet recruiting 4
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Clinical Trial Sponsors for Ofloxacin

Sponsor Name

Sponsor Name for Ofloxacin
Sponsor Trials
MacroChem Corporation 2
Genaera Corporation 2
University of Louisville 1
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Sponsor Type

Sponsor Type for Ofloxacin
Sponsor Trials
Other 28
Industry 7
U.S. Fed 1
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Serving hundreds of leading biopharmaceutical companies globally:

Fish and Richardson
Johnson and Johnson
Baxter
Farmers Insurance
US Army
Harvard Business School
Chinese Patent Office
Covington
Queensland Health

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