Men and women who have suffered sexual and/or physical abuse before the age of 12 are at
increased risk for anxiety and mood disorders, other serious psychiatric disorders, and
likely medical illnesses. What is not known is whether adult survivors of childhood adversity
experience heightened negative emotions and increased physical responses due to altered
norepinephrine or serotonin systems in their brains and bodies. The investigators expect to
see that survivors of childhood adversity experience heightened negative emotions and
increased physical responses to stress.
Men and women who have suffered sexual and/or physical abuse before the age of 12 are at
increased risk for anxiety and mood disorders, other serious psychiatric disorders, and
likely medical illnesses. What is not known is whether adult survivors of childhood adversity
experience heightened negative emotions and increased physical responses due to altered
norepinephrine or serotonin systems in their brains and bodies. The investigators expect to
see that survivors of childhood adversity experience heightened negative emotions and
increased physical responses to stress.
Naltrexone & SSRI in Alcoholics With Depression/PTSD
Completed
Yale University
Phase 3
2001-10-01
The purpose of this study is to evaluate the efficacy of naltrexone in combination with an
SSRI to reduce alcohol consumption in alcoholic patients with comorbid PTSD and depression.
We hypothesize that the combination of naltrexone and SSRI will exhibit a greater decrease in
alcohol consumption than that seen with treatment with SSRI alone, or with a combination of
another class of antidepressant and naltrexone. We also hypothesize that SSRI will be
effective in treating PTSD and depressive symptoms and naltrexone will be well tolerated.
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