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Generated: December 12, 2018

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CLINICAL TRIALS PROFILE FOR NORFLOXACIN

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Clinical Trials for Norfloxacin

Trial ID Title Status Sponsor Phase Summary
NCT00163982 Vasoactive Peptides in Portal Pressure Unknown status Bayside Health N/A This study is looking at the detection of vasoactive peptides in portal hypertension.
NCT00359853 Norfloxacin In The Primary Prophylaxis Of Spontaneous Bacterial Peritonitis Completed Hospital Clinic of Barcelona Phase 4 Advanced liver disease and low ascitic fluid protein concentration have been identified as risk factors for spontaneous bacterial peritonitis in cirrhosis. Moreover, renal impairment and hyponatremia increase mortality rate of this infection. Aims: To investigate if oral administration of norfloxacin prevents the first episode of SBP, hepatorenal syndrome and improves survival in cirrhotic patients with ascites and low protein concentration in ascitic fluid (<15 g/L) and at least one of the following inclusion criteria: functional renal failure (serum creatinine ≥ 1,2 mg/dl or BUN ≥ 25 mg/dl), hyponatremia (serum sodium ≤ 130 mEq/L) or advanced liver disease (Child ≥ 9 points with serum bilirubin ≥ 3 mg/dl). Methods: Prospective, multicenter, randomized, double-blind placebo controlled trial comparing oral norfloxacin (400 mg/d; n=35) with placebo (n=35).
NCT00362752 A Pilot Study of Norfloxacin for Hepatopulmonary Syndrome Completed University of Toronto Phase 2 The hepatopulmonary syndrome (HPS)and pre-HPS is a disease seen in patients with chronic liver disease, whereby patients develop dilations in the blood vessels of the lungs, resulting in low oxygen levels and shortness of breath. In this study, each HPS and pre-HPS subject will be treated with a commonly used antibiotic called "norfloxacin" (approved for use in the treatment of gonorrhea, prostatitis and urinary tract infections) for a 4-week period. In order to ensure that any observed improvement was indeed due to norfloxacin, each subject will also be treated with a separate 4-week course of an identical placebo. There will also be a 4 week wash-out period (no study medication/placebo) between the 2 courses of treatment. The primary aim of the study will be to measure improvements in oxygen levels while on norfloxacin, although a number of secondary parameters will also be followed.
NCT00362752 A Pilot Study of Norfloxacin for Hepatopulmonary Syndrome Completed St. Michael's Hospital, Toronto Phase 2 The hepatopulmonary syndrome (HPS)and pre-HPS is a disease seen in patients with chronic liver disease, whereby patients develop dilations in the blood vessels of the lungs, resulting in low oxygen levels and shortness of breath. In this study, each HPS and pre-HPS subject will be treated with a commonly used antibiotic called "norfloxacin" (approved for use in the treatment of gonorrhea, prostatitis and urinary tract infections) for a 4-week period. In order to ensure that any observed improvement was indeed due to norfloxacin, each subject will also be treated with a separate 4-week course of an identical placebo. There will also be a 4 week wash-out period (no study medication/placebo) between the 2 courses of treatment. The primary aim of the study will be to measure improvements in oxygen levels while on norfloxacin, although a number of secondary parameters will also be followed.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Norfloxacin

Condition Name

Condition Name for Norfloxacin
Intervention Trials
Spontaneous Bacterial Peritonitis 5
Cirrhosis 3
Liver Cirrhosis 2
Urinary Tract Infections 2
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Condition MeSH

Condition MeSH for Norfloxacin
Intervention Trials
Peritonitis 8
Liver Cirrhosis 6
Fibrosis 5
Ascites 3
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Clinical Trial Locations for Norfloxacin

Trials by Country

Trials by Country for Norfloxacin
Location Trials
India 4
Korea, Republic of 3
Brazil 2
China 1
Spain 1
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Clinical Trial Progress for Norfloxacin

Clinical Trial Phase

Clinical Trial Phase for Norfloxacin
Clinical Trial Phase Trials
Phase 4 5
Phase 3 8
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for Norfloxacin
Clinical Trial Phase Trials
Completed 6
Unknown status 5
Recruiting 3
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Clinical Trial Sponsors for Norfloxacin

Sponsor Name

Sponsor Name for Norfloxacin
Sponsor Trials
Govind Ballabh Pant Hospital 2
Sungkyunkwan University 1
International Centre for Diarrhoeal Disease Research, Bangladesh 1
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Sponsor Type

Sponsor Type for Norfloxacin
Sponsor Trials
Other 30
Industry 3
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Serving hundreds of leading biopharmaceutical companies globally:

Baxter
Boehringer Ingelheim
Dow
Merck
Cipla
Cantor Fitzgerald
Express Scripts
Deloitte
Medtronic

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