Congenital Adrenal Hyperplasia: Calcium Channels as Therapeutic Targets
National Center for Research Resources (NCRR)
Phase 1/Phase 2
This study will test the ability of extended release nifedipine (Procardia XL), a blood
pressure medication, to permit a decrease in the dose of glucocorticoid medication children
take to treat congenital adrenal hyperplasia (CAH).
To determine the relative efficacy of usual medical care and a course of treatment by
thermal biofeedback in reducing vasospastic attacks characteristic of Raynaud's syndrome.
Also, to confirm the frequency and severity of attacks, examine the role of
psychophysiological factors in precipitating attacks, and assess the influence of treatment
on health quality of life.
A Study To Test An Anti-Rejection Therapy After Kidney Transplantation
National Institute of Allergy and Infectious Diseases (NIAID)
Kidney transplantation is often successful. However, despite aggressive anti-rejection drug
therapy, some patients will reject their new kidney. This study is designed to test two
anti-rejection approaches. Two medications in this study are currently used in children, but
there is no information regarding which drug is safer or more effective.
Survival rates in renal transplantation are unacceptably low. Therefore, there is a need for
an improved post-transplant treatment, such as the induction therapy used in this study.
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