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Generated: December 13, 2018

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CLINICAL TRIALS PROFILE FOR NEXIUM 24HR

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Clinical Trials for Nexium 24hr

Trial ID Title Status Sponsor Phase Summary
NCT00069823 Study of Acid Reflux in Asthma Completed American Lung Association Asthma Clinical Research Centers Phase 3 The purpose of this study is to determine if subjects with symptomatic asthma who are assigned to treatment with a proton pump inhibitor (PPI) drug such as Nexium have fewer asthma attacks than similar subjects assigned to placebo treatment.
NCT00069823 Study of Acid Reflux in Asthma Completed National Heart, Lung, and Blood Institute (NHLBI) Phase 3 The purpose of this study is to determine if subjects with symptomatic asthma who are assigned to treatment with a proton pump inhibitor (PPI) drug such as Nexium have fewer asthma attacks than similar subjects assigned to placebo treatment.
NCT00069823 Study of Acid Reflux in Asthma Completed Johns Hopkins Bloomberg School of Public Health Phase 3 The purpose of this study is to determine if subjects with symptomatic asthma who are assigned to treatment with a proton pump inhibitor (PPI) drug such as Nexium have fewer asthma attacks than similar subjects assigned to placebo treatment.
NCT00123656 Comparison of Esomeprazole to Aerosolized, Swallowed Fluticasone for Eosinophilic Esophagitis Completed American Society for Gastrointestinal Endoscopy Phase 2 Eosinophilic esophagitis (EE) is a recently recognized entity. It has been thought to be related to both allergies and acid reflux. There have been reports that both swallowed, aerosolized steroids and proton pump inhibitors have been effective treatments. The researchers propose to directly compare the efficacy of aerosolized fluticasone to esomeprazole in the treatment of eosinophilic esophagitis. The hypothesis is that aerosolized fluticasone (Flovent) will be more effective in relieving symptoms of EE than esomeprazole (Nexium) treatment. Patients will undergo endoscopy, pH monitoring and manometry for diagnosis. Following diagnosis of EE by pathology (biopsy of esophagus), patients will be randomized to esomeprazole or swallowed fluticasone for 8 weeks. At the end of 8 weeks, subjects will be asked to repeat upper endoscopy with biopsies. Three questionnaires (dysphagia, gastroesophageal reflux disease [GERD], and allergy) will be completed by the patient at the first endoscopy and at the end endoscopy. The primary objective is to measure change in eosinophil infiltration of the esophagus in response to treatment of allergy (swallowed fluticasone) versus treatment for reflux (esomeprazole) in EE patients.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Nexium 24hr

Condition Name

Condition Name for Nexium 24hr
Intervention Trials
GERD 15
Gastroesophageal Reflux Disease 12
Healthy 11
Gastroesophageal Reflux 7
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Condition MeSH

Condition MeSH for Nexium 24hr
Intervention Trials
Gastroesophageal Reflux 37
Ulcer 12
Esophagitis 11
Dyspepsia 10
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Clinical Trial Locations for Nexium 24hr

Trials by Country

Trials by Country for Nexium 24hr
Location Trials
United States 157
Japan 57
Canada 41
Italy 29
Germany 24
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Trials by US State

Trials by US State for Nexium 24hr
Location Trials
Texas 11
California 10
Pennsylvania 8
New York 8
North Carolina 7
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Clinical Trial Progress for Nexium 24hr

Clinical Trial Phase

Clinical Trial Phase for Nexium 24hr
Clinical Trial Phase Trials
Phase 4 50
Phase 3 30
Phase 2/Phase 3 2
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Clinical Trial Status

Clinical Trial Status for Nexium 24hr
Clinical Trial Phase Trials
Completed 91
Unknown status 9
Recruiting 9
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Clinical Trial Sponsors for Nexium 24hr

Sponsor Name

Sponsor Name for Nexium 24hr
Sponsor Trials
AstraZeneca 60
Chinese University of Hong Kong 4
CJ HealthCare Corporation 3
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Sponsor Type

Sponsor Type for Nexium 24hr
Sponsor Trials
Industry 94
Other 68
U.S. Fed 4
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Serving hundreds of leading biopharmaceutical companies globally:

Fuji
Harvard Business School
McKesson
Cerilliant
Citi
Healthtrust
Colorcon
Medtronic
Julphar

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