The goal of this clinical research study is to learn if the drug nesiritide (Natrecor) is
effective in lowering the pressure in your lungs.
The primary objective of this study is to establish that Nesiritide (Natrecor) is effective
in reducing pulmonary hypertension (PHTN) acutely as measured by a 20% reduction in the mean
pulmonary arterial (PA) pressure. The secondary objectives will include: improvement in
pulmonary vascular resistance (PVR), patient symptoms, exercise tolerance, frequency of
toxicity, and surgeon's willingness to proceed with operation.
Use of Nesiritide in the Management of Acute Diastolic Heart Failure
M.D. Anderson Cancer Center
Primary objective is to assess the effect of nesiritide in decreasing left ventricular (LV)
filling pressure, defined as pulmonary artery capillary wedge pressure (PCWP) in a group of
patients admitted with acute diastolic heart failure.
Secondary objectives include: improvement in symptoms, exercise tolerance, improvement in
Doppler diastolic filling parameters in patients with diastolic heart failure.
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