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Generated: February 16, 2019

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CLINICAL TRIALS PROFILE FOR NAPROXEN

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Clinical Trials for Naproxen

Trial ID Title Status Sponsor Phase Summary
NCT00001955 Study of Etanercept and Celecoxib to Treat Temporomandibular Disorders (Painful Joint Conditions) Completed National Institute of Dental and Craniofacial Research (NIDCR) Phase 2 This 2-part study will evaluate the effectiveness and side effects of two anti-inflammatory drugs for relieving pain and improving jaw function in patients with temporomandibular disorder (TMD). Part 1 will evaluate celecoxib (Celebrex); Part 2 will evaluate etanercept (Enbrel). The Food and Drug Administration has approved both of these drugs for treating certain forms of arthritis. Patients between the ages of 18 and 65 years with painful jaw joint conditions may be eligible for this study. Candidates will complete several written questionnaires about their jaw condition and will undergo a medical history, complete TMD evaluation, blood and urine tests, and imaging studies of the temporomandibular joint, such as X-rays and magnetic resonance imaging. Patients will rate the quality and intensity of their pain before beginning treatment. At certain periods during the study, they will also keep a pain diary, twice a day recording the intensity and magnitude of their pain. Part 1 - Celecoxib: Patients will be randomly assigned to receive either 1) celecoxib twice a day by mouth; 2) naproxen (a non-steroidal anti-inflammatory drug) twice a day by mouth; or 3) a placebo (inactive pill) twice a day by mouth. Part 2 - Etanercept: Patients will be randomly assigned to receive either 1) etanercept injected under the skin or 2) saline (an inactive placebo) injected under the skin. Patients in this group will also undergo two aspirations of fluid from the jaw joint - once before treatment begins and again 6 weeks later. For this procedure, the joint is numbed with an anesthetic and then a needle is inserted into the jaw space to withdraw fluid, which will be analyzed for inflammatory processes in the joint. All patients will have a final evaluation 6 weeks after beginning treatment, including a TMD physical examination, laboratory and X-ray tests as required. The pain diary and questionnaires will be collected at this visit.
NCT00004845 A Multicenter Trial of Rofecoxib and Naproxen in Alzheimer's Disease (NSAID Study) Completed Alzheimer's Disease Cooperative Study (ADCS) Phase 2/Phase 3 The primary specific aim of this clinical trial is to determine whether treatment with rofecoxib or naproxen for one year will slow the rate of decline of cognitive function in patients with Alzheimer's disease (AD) as measured by ADAScog.
NCT00004845 A Multicenter Trial of Rofecoxib and Naproxen in Alzheimer's Disease (NSAID Study) Completed National Institute on Aging (NIA) Phase 2/Phase 3 The primary specific aim of this clinical trial is to determine whether treatment with rofecoxib or naproxen for one year will slow the rate of decline of cognitive function in patients with Alzheimer's disease (AD) as measured by ADAScog.
NCT00007189 Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT) Completed Johns Hopkins University Phase 3 The purpose of this trial is to test the ability of the non-steroidal anti-inflammatory medications naproxen and celecoxib to delay or prevent the onset of AD and age-related cognitive decline.
NCT00007189 Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT) Completed National Institute on Aging (NIA) Phase 3 The purpose of this trial is to test the ability of the non-steroidal anti-inflammatory medications naproxen and celecoxib to delay or prevent the onset of AD and age-related cognitive decline.
NCT00007189 Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT) Completed University of Washington Phase 3 The purpose of this trial is to test the ability of the non-steroidal anti-inflammatory medications naproxen and celecoxib to delay or prevent the onset of AD and age-related cognitive decline.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Naproxen

Condition Name

Condition Name for Naproxen
Intervention Trials
Osteoarthritis 29
Healthy 20
Pain 18
Migraine Disorders 18
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Condition MeSH

Condition MeSH for Naproxen
Intervention Trials
Osteoarthritis 48
Migraine Disorders 34
Osteoarthritis, Knee 28
Back Pain 16
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Clinical Trial Locations for Naproxen

Trials by Country

Trials by Country for Naproxen
Location Trials
Canada 46
Brazil 23
Mexico 14
United Kingdom 13
Germany 10
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Trials by US State

Trials by US State for Naproxen
Location Trials
Texas 68
California 56
Florida 53
New York 47
Pennsylvania 42
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Clinical Trial Progress for Naproxen

Clinical Trial Phase

Clinical Trial Phase for Naproxen
Clinical Trial Phase Trials
Phase 4 62
Phase 3 61
Phase 2/Phase 3 5
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Clinical Trial Status

Clinical Trial Status for Naproxen
Clinical Trial Phase Trials
Completed 191
Recruiting 29
Terminated 12
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Clinical Trial Sponsors for Naproxen

Sponsor Name

Sponsor Name for Naproxen
Sponsor Trials
GlaxoSmithKline 27
Pfizer 22
Bayer 20
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Sponsor Type

Sponsor Type for Naproxen
Sponsor Trials
Industry 176
Other 137
NIH 19
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Serving hundreds of leading biopharmaceutical companies globally:

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Cipla
Cantor Fitzgerald
Federal Trade Commission
Colorcon
Teva
Deloitte

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