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Generated: December 10, 2018

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CLINICAL TRIALS PROFILE FOR MOVANTIK

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Clinical Trials for Movantik

Trial ID Title Status Sponsor Phase Summary
NCT02705378 The Effect of Naloxegol on Refractory Constipation in the Intensive Care Unit Not yet recruiting AstraZeneca Phase 3 Naloxegol has recently been approved by the US Food and Drug Administration to treat opioid induced constipation in non-cancer chronic pain patients. Its effectiveness in acute care patients, however, is not known. Therefore, the researchers' goal is to investigate whether naloxegol is superior to osmotic laxatives for refractory constipation in ICU patients already receiving prophylactic stool softeners and simulant laxatives through a double-blind, randomized control trial.
NCT02705378 The Effect of Naloxegol on Refractory Constipation in the Intensive Care Unit Not yet recruiting Massachusetts General Hospital Phase 3 Naloxegol has recently been approved by the US Food and Drug Administration to treat opioid induced constipation in non-cancer chronic pain patients. Its effectiveness in acute care patients, however, is not known. Therefore, the researchers' goal is to investigate whether naloxegol is superior to osmotic laxatives for refractory constipation in ICU patients already receiving prophylactic stool softeners and simulant laxatives through a double-blind, randomized control trial.
NCT02737059 Effect of Naloxegol on Gastric, Small Bowel, and Colonic Transit in Healthy Subjects Recruiting AstraZeneca Phase 1 This is a single center, randomized, double-blind, placebo-controlled, parallel-group, Phase I study of the effects of naloxegol, a novel mu-opioid antagonist, on gastrointestinal and colonic transit in the presence or absence of the mu-opiate, codeine. There is a need to develop effective medications for the treatment of opiate-induced constipation and other motility disorders. Currently available opiates are complicated by addictive potential and induction of troublesome constipation.
NCT02737059 Effect of Naloxegol on Gastric, Small Bowel, and Colonic Transit in Healthy Subjects Recruiting Michael Camilleri Phase 1 This is a single center, randomized, double-blind, placebo-controlled, parallel-group, Phase I study of the effects of naloxegol, a novel mu-opioid antagonist, on gastrointestinal and colonic transit in the presence or absence of the mu-opiate, codeine. There is a need to develop effective medications for the treatment of opiate-induced constipation and other motility disorders. Currently available opiates are complicated by addictive potential and induction of troublesome constipation.
NCT02745353 Naloxegol in Cancer Opioid-Induced Constipation Not yet recruiting AstraZeneca Phase 2 The purpose of this study is to compare the effect of naloxegol versus the patient's usual care in treating opioid-induced constipation, as well as the effect on the patient's quality of life and how much pain is experienced. Also, the purpose of this study is to compare whether treatment with naloxegol versus usual care has any impact on the number of hospital or clinic visits or telephone calls to the patient's physician that are related to constipation, and to determine the patient's preference for continuing to receive naloxegol as treatment for opioid-induced constipation.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Movantik

Condition Name

Condition Name for Movantik
Intervention Trials
Constipation 6
Constipation Drug Induced 2
Critical Illness 1
Pain, Postoperative 1
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Condition MeSH

Condition MeSH for Movantik
Intervention Trials
Constipation 8
Critical Illness 2
Pain, Postoperative 1
Esophageal Diseases 1
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Clinical Trial Locations for Movantik

Trials by Country

Trials by Country for Movantik
Location Trials
United States 10
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Trials by US State

Trials by US State for Movantik
Location Trials
Ohio 3
Massachusetts 2
California 1
Pennsylvania 1
North Carolina 1
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Clinical Trial Progress for Movantik

Clinical Trial Phase

Clinical Trial Phase for Movantik
Clinical Trial Phase Trials
Phase 4 6
Phase 3 1
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for Movantik
Clinical Trial Phase Trials
Recruiting 6
Not yet recruiting 5
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Clinical Trial Sponsors for Movantik

Sponsor Name

Sponsor Name for Movantik
Sponsor Trials
AstraZeneca 7
Massachusetts General Hospital 2
QuintilesIMS, Inc. 1
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Sponsor Type

Sponsor Type for Movantik
Sponsor Trials
Other 11
Industry 7
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Serving hundreds of leading biopharmaceutical companies globally:

Moodys
Federal Trade Commission
QuintilesIMS
Dow
Boehringer Ingelheim
McKinsey
Merck
Covington
Johnson and Johnson

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