Combination Chemotherapy and Bone Marrow Transplant in Treating Patients With Refractory or Recurrent Ovarian Cancer
RATIONALE: Drugs used in chemotherapy, such as cyclophosphamide, carboplatin, and
mitoxantrone, work in different ways to stop the growth of tumor cells, either by killing the
cells or by stopping them from dividing. Giving chemotherapy with autologous bone marrow
transplant may allow the doctor to give higher doses of chemotherapy and kill more tumor
PURPOSE: This phase II trial is studying how well chemotherapy and autologous bone marrow
transplant work in treating patients with refractory or recurrent ovarian cancer.
Combination Chemotherapy Compared With Mitoxantrone in Treating Older Patients With Advanced Breast Cancer
Leiden University Medical Center
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. Giving drugs in different combinations may kill more tumor cells.
PURPOSE: Randomized phase II trial to compare the effectiveness of cyclophosphamide,
methotrexate, and fluorouracil with mitoxantrone in treating older patients with recurrent or
metastatic breast cancer.
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