Phase II Study of Novantrone(R) (Mitoxantrone) and Etoposide in Patients With HIV Associated Large Cell and Immunoblastic Lymphomas
Completed
Lederle Laboratories
Phase 2
1969-12-31
To determine the efficacy and toxicity of the combination of mitoxantrone hydrochloride (
Novantrone ) and etoposide in the treatment of patients with HIV associated lymphomas.
Combination Chemotherapy and Bone Marrow Transplant in Treating Patients With Refractory or Recurrent Ovarian Cancer
Completed
Loyola University
Phase 2
1991-02-01
RATIONALE: Drugs used in chemotherapy, such as cyclophosphamide, carboplatin, and
mitoxantrone, work in different ways to stop the growth of tumor cells, either by killing the
cells or by stopping them from dividing. Giving chemotherapy with autologous bone marrow
transplant may allow the doctor to give higher doses of chemotherapy and kill more tumor
cells.
PURPOSE: This phase II trial is studying how well chemotherapy and autologous bone marrow
transplant work in treating patients with refractory or recurrent ovarian cancer.
Combination Chemotherapy Compared With Mitoxantrone in Treating Older Patients With Advanced Breast Cancer
Unknown status
Leiden University Medical Center
Phase 2
1992-07-01
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. Giving drugs in different combinations may kill more tumor cells.
PURPOSE: Randomized phase II trial to compare the effectiveness of cyclophosphamide,
methotrexate, and fluorouracil with mitoxantrone in treating older patients with recurrent or
metastatic breast cancer.
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