A Placebo-Controlled Study of a Combination of Metyrapone and Oxazepam in Cocaine Addiction
Completed
Embera NeuroTherapeutics, Inc.
N/A
2007-12-01
Subjects will be randomly assigned to receive either one of the two potential dose
combinations of the study medications or placebo over 6 weeks. The study will include twice
weekly visits to the research clinic for laboratory studies, safety assessments and urine
drug screens. Subjects will also be questioned regarding drug craving and mood symptoms.
Stress Biomarkers:Attaching Biological Meaning to Field Friendly Salivary Measures
Completed
University of Michigan
Phase 1
2012-10-01
Cortisol is a stress hormone that can be measured in saliva. This has provided a convenient
way to evaluate the biological impact of day-to-day stressors that people encounter as they
go about their lives, since saliva is so easy to collect. However, the biological meaning of
saliva cortisol measures has never been carefully examined. The goal of this study is to
collect saliva from a large group of people as they go about their every-day lives, to
measure their cortisol levels, and then study them in the laboratory where Investigators can
learn more about how their stress response system (which produces cortisol) is really
functioning. Investigators can then determine much more precisely what saliva cortisol levels
really mean in terms of stress system biology. This will allow investigators to obtain much
more useful information from the next decade of research on naturalistic stress and its
biological impact using saliva cortisol measures, helping investigators to understand how
stress undermines health and how to combat this effect.
Effects of Metyrapone in Patients With Endogenous Cushing's Syndrome
Completed
HRA Pharma
Phase 3
2015-04-01
The purpose of this prospective, international phase III/IV study is to assess the efficacy
and safety of metyrapone in patients with endogenous Cushing's syndrome during up to 36 weeks
of treatment. The ability of metyrapone (250 mg capsules) to normalize urinary free cortisol
(UFC) levels will be assessed during up to 36 weeks (9 months) of treatment.
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