Hypertension is one of the most common medical problems in the United States and in the VA
health care system. It has been well-documented that hypertension can be effectively
treated. However, there remain important unresolved clinical questions in the area of
antihypertensive treatment. For example, how much is mortality affected by visit compliance,
blood pressure control and type of antihypertensive agent? Or, are some regimens associated
with more morbidity than others? Or, are there inexpensive regimens that are as effective as
more expensive regimens? The amount of data that is available from this demonstration
project (currently 6,100 patients) will help address these questions. The answers to these
questions should result in better care for veterans with hypertension.
Fasting Study of Metolazone Tablets 2.5 mg and Zaroloxyn® Tablets 2.5 mg
The objective of this study was to investigate the bioequivalence of Mylan metolazone 2.5 mg
tablets to Celltech Zaroxolyn® 2.5 mg tablets following a single, oral 10 mg (4 x 2.5 mg)
dose administration under fasting conditions.
Fasting Study of Metolazone Tablets 5 mg and Zaroloxyn® Tablets 5 mg
The objective of this study was to investigate the bioequivalence of Mylan metolazone 5 mg
tablets to Celltech Zaroxolyn® 5 mg tablets following a single, oral 10 mg (2 x 5 mg) dose
administration under fasting conditions.
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