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Last Updated: July 23, 2024

CLINICAL TRIALS PROFILE FOR METOLAZONE


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All Clinical Trials for Metolazone

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00007592 ↗ Hypertension Screening and Treatment Program Completed US Department of Veterans Affairs 1989-06-01 Hypertension is one of the most common medical problems in the United States and in the VA health care system. It has been well-documented that hypertension can be effectively treated. However, there remain important unresolved clinical questions in the area of antihypertensive treatment. For example, how much is mortality affected by visit compliance, blood pressure control and type of antihypertensive agent? Or, are some regimens associated with more morbidity than others? Or, are there inexpensive regimens that are as effective as more expensive regimens? The amount of data that is available from this demonstration project (currently 6,100 patients) will help address these questions. The answers to these questions should result in better care for veterans with hypertension.
NCT00007592 ↗ Hypertension Screening and Treatment Program Completed VA Office of Research and Development 1989-06-01 Hypertension is one of the most common medical problems in the United States and in the VA health care system. It has been well-documented that hypertension can be effectively treated. However, there remain important unresolved clinical questions in the area of antihypertensive treatment. For example, how much is mortality affected by visit compliance, blood pressure control and type of antihypertensive agent? Or, are some regimens associated with more morbidity than others? Or, are there inexpensive regimens that are as effective as more expensive regimens? The amount of data that is available from this demonstration project (currently 6,100 patients) will help address these questions. The answers to these questions should result in better care for veterans with hypertension.
NCT00649051 ↗ Fasting Study of Metolazone Tablets 2.5 mg and Zaroloxyn® Tablets 2.5 mg Completed Mylan Pharmaceuticals Phase 1 2002-12-01 The objective of this study was to investigate the bioequivalence of Mylan metolazone 2.5 mg tablets to Celltech Zaroxolyn® 2.5 mg tablets following a single, oral 10 mg (4 x 2.5 mg) dose administration under fasting conditions.
NCT00649181 ↗ Fasting Study of Metolazone Tablets 5 mg and Zaroloxyn® Tablets 5 mg Completed Mylan Pharmaceuticals Phase 1 2003-10-01 The objective of this study was to investigate the bioequivalence of Mylan metolazone 5 mg tablets to Celltech Zaroxolyn® 5 mg tablets following a single, oral 10 mg (2 x 5 mg) dose administration under fasting conditions.
NCT00650195 ↗ Fasting Study of Metolazone Tablets 10 mg and Zaroloxyn® Tablets 10 mg Completed Mylan Pharmaceuticals Phase 1 2004-02-01 The objective of this study was to investigate the bioequivalence of Mylan metolazone 10 mg tablets to Celltech Zaroxolyn® 10 mg tablets following a single, oral 10 mg (1 x 10 mg) dose administration under fasting conditions.
NCT00690521 ↗ A Comparison of Hydrochlorothiazide and Metolazone in Combination With Furosemide in Congestive Heart Failure Patients Unknown status University of New Mexico Phase 4 2003-01-01 The purpose of this research study is to compare the effectiveness of hydrochlorothiazide or metolazone in combination with furosemide. Patients with heart failure suffer from swelling because of too much fluid in the body. Furosemide, hydrochlorothiazide, and metolazone are all water pills used to treat the swelling. For most patients, taking furosemide alone is successful. However, sometimes patients need to add another water pill. Doctors usually add either metolazone or hydrochlorothiazide. It is not clear which water pill is better when added to furosemide. The purpose of this study is to determine which water pill when added to furosemide is the best at reducing excess fluid in the body.
NCT00904488 ↗ Oral Metolazone and Intermittent Intravenous Furosemide Versus Continuous Infusion Furosemide in Acute Heart Failure Terminated University of Illinois at Chicago Phase 4 2008-10-01 The purpose of this prospective, randomized, open-label study is to compare two diuretic strategies in patients with acute decompensated heart failure (ADHF): the addition of an oral thiazide diuretic to intravenous bolus (IVB) loop diuretic will be compared to transition from IVB to continuous infusion (CI) loop diuretic.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Metolazone

Condition Name

Condition Name for Metolazone
Intervention Trials
Acute Heart Failure 4
Congestive Heart Failure 4
Acute Decompensated Heart Failure 3
Healthy 3
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Condition MeSH

Condition MeSH for Metolazone
Intervention Trials
Heart Failure 16
Renal Insufficiency, Chronic 2
Kidney Diseases 2
Hypernatremia 1
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Clinical Trial Locations for Metolazone

Trials by Country

Trials by Country for Metolazone
Location Trials
United States 24
United Kingdom 2
Italy 2
Israel 1
Puerto Rico 1
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Trials by US State

Trials by US State for Metolazone
Location Trials
California 3
West Virginia 2
Virginia 2
Tennessee 2
Ohio 2
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Clinical Trial Progress for Metolazone

Clinical Trial Phase

Clinical Trial Phase for Metolazone
Clinical Trial Phase Trials
Phase 4 8
Phase 3 4
Phase 2 3
[disabled in preview] 7
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Clinical Trial Status

Clinical Trial Status for Metolazone
Clinical Trial Phase Trials
Completed 6
Recruiting 5
Withdrawn 4
[disabled in preview] 8
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Clinical Trial Sponsors for Metolazone

Sponsor Name

Sponsor Name for Metolazone
Sponsor Trials
Mylan Pharmaceuticals 3
University of Glasgow 1
University of North Carolina, Chapel Hill 1
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Sponsor Type

Sponsor Type for Metolazone
Sponsor Trials
Other 30
Industry 4
U.S. Fed 2
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