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Generated: September 17, 2019

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CLINICAL TRIALS PROFILE FOR METHOTREXATE LPF

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Clinical Trials for Methotrexate Lpf

Trial ID Title Status Sponsor Phase Summary
NCT00000361 Autoimmunity in Inner Ear Disease Terminated National Institute on Deafness and Other Communication Disorders (NIDCD) Phase 3 The purpose of this study is to determine whether prednisone, methotrexate, and cyclophosphamide are effective in the treatment of rapidly progressive sensorineural hearing loss in both ears. This condition is called autoimmune inner ear disease (AIED), because it is thought that the hearing loss is triggered by an autoimmune process. Treatment attempts to suppress or control this process with powerful anti-inflammatory drugs. This is a Phase III, outpatient study. All study participants will be assigned to one of four different groups testing the experimental use of drugs. The study is scheduled to run for 18 months, with a minimum of 11 visits per participant.
NCT00000395 Antifolate Effectiveness in Arthritis Completed National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Phase 2 This study looks at how the arthritis drug methotrexate works in low doses to treat rheumatoid arthritis. (High doses of methotrexate are used to treat some types of cancer.) Methotrexate blocks the action of the B-vitamin known as folic acid. We are studying the biochemical reactions affected by this vitamin because we think that blocking many of these reactions may be necessary for methotrexate to work in treating rheumatoid arthritis. Through these studies, we hope to gain a better understanding of how this drug and related drugs work as treatments for arthritis.
NCT00000395 Antifolate Effectiveness in Arthritis Completed Office of Dietary Supplements (ODS) Phase 2 This study looks at how the arthritis drug methotrexate works in low doses to treat rheumatoid arthritis. (High doses of methotrexate are used to treat some types of cancer.) Methotrexate blocks the action of the B-vitamin known as folic acid. We are studying the biochemical reactions affected by this vitamin because we think that blocking many of these reactions may be necessary for methotrexate to work in treating rheumatoid arthritis. Through these studies, we hope to gain a better understanding of how this drug and related drugs work as treatments for arthritis.
NCT00000395 Antifolate Effectiveness in Arthritis Completed University of Alabama at Birmingham Phase 2 This study looks at how the arthritis drug methotrexate works in low doses to treat rheumatoid arthritis. (High doses of methotrexate are used to treat some types of cancer.) Methotrexate blocks the action of the B-vitamin known as folic acid. We are studying the biochemical reactions affected by this vitamin because we think that blocking many of these reactions may be necessary for methotrexate to work in treating rheumatoid arthritis. Through these studies, we hope to gain a better understanding of how this drug and related drugs work as treatments for arthritis.
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Clinical Trial Conditions for Methotrexate Lpf

Condition Name

Condition Name for Methotrexate Lpf
Intervention Trials
Rheumatoid Arthritis 417
Leukemia 197
Lymphoma 135
Arthritis, Rheumatoid 73
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Condition MeSH

Condition MeSH for Methotrexate Lpf
Intervention Trials
Arthritis 560
Arthritis, Rheumatoid 526
Leukemia 389
Lymphoma 263
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Clinical Trial Locations for Methotrexate Lpf

Trials by Country

Trials by Country for Methotrexate Lpf
Location Trials
Canada 703
Hungary 97
Netherlands 90
South Africa 81
India 81
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Trials by US State

Trials by US State for Methotrexate Lpf
Location Trials
Texas 384
California 349
Pennsylvania 299
Florida 284
New York 280
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Clinical Trial Progress for Methotrexate Lpf

Clinical Trial Phase

Clinical Trial Phase for Methotrexate Lpf
Clinical Trial Phase Trials
Phase 4 196
Phase 3 451
Phase 2/Phase 3 47
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Clinical Trial Status

Clinical Trial Status for Methotrexate Lpf
Clinical Trial Phase Trials
Completed 820
Recruiting 340
Terminated 153
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Clinical Trial Sponsors for Methotrexate Lpf

Sponsor Name

Sponsor Name for Methotrexate Lpf
Sponsor Trials
National Cancer Institute (NCI) 292
M.D. Anderson Cancer Center 86
Hoffmann-La Roche 70
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Sponsor Type

Sponsor Type for Methotrexate Lpf
Sponsor Trials
Other 1651
Industry 847
NIH 375
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