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Generated: December 17, 2018

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CLINICAL TRIALS PROFILE FOR MEPERIDINE HYDROCHLORIDE

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Clinical Trials for Meperidine Hydrochloride

Trial ID Title Status Sponsor Phase Summary
NCT00154895 Additional Minocycline Pleurodesis After Thoracoscopic Procedures for Primary Spontaneous Pneumothorax Unknown status National Science Council, Taiwan Phase 3 To test if additional minocycline pleurodesis after thoracoscopic procedures can reduce the rates of ipsilateral recurrence for patients with primary spontaneous pneumothorax.
NCT00154895 Additional Minocycline Pleurodesis After Thoracoscopic Procedures for Primary Spontaneous Pneumothorax Unknown status National Taiwan University Hospital Phase 3 To test if additional minocycline pleurodesis after thoracoscopic procedures can reduce the rates of ipsilateral recurrence for patients with primary spontaneous pneumothorax.
NCT00240123 Effect of Benadryl Sedation During ERCP or EUS Withdrawn University of Rochester Phase 1 The purpose of the study is to determine if adding Benadryl improves sedation for patients scheduled to undergo ERCP or EUS procedures.
NCT00286052 Impact of Low Dose Naloxone on Fentanyl Requirements in Pediatric ICU Patients Completed University of Texas Southwestern Medical Center Phase 3 Recently there has been an increased awareness in the need for adequate sedation and pain control for Pediatric Intensive Care Unit (ICU) patients. Fentanyl is an opioid commonly used in Pediatric ICU patients to decrease pain and increase sedation. Although opioids (e.g. morphine and fentanyl) provide excellent pain relief, they have many side effects including dependence, tolerance and withdrawal. These side effects lead to increased doses in order to maintain pain control and/or sedation. There have been a few adult studies pointing to some possible treatments. For example, giving low dose naloxone along with opioids. Adult studies show that this combination not only decreases the frequency of opioid side effects, but also improves pain control and prevents the development of tolerance. We propose that children who receive low dose naloxone infusions along with fentanyl infusions will demonstrate: 1) decreased total daily doses of Fentanyl, 2) decreased frequency of withdrawal and 3) increased pain and sedation control. In this randomized, blinded prospective trial we will enroll 168 Pediatric ICU patients. Patients will receive either low dose naloxone or placebo simultaneously with their fentanyl infusion. Pain and sedation will be assessed using the Modified Motor Activity Assessment Scale (MMAAS). The fentanyl infusion will be increased to provide adequate pain control and/or sedation. Naloxone infusion will not be adjusted. Approximately 48 hours prior to removal from the ventilator, patients will have their fentanyl infusions decreased while being monitored for withdrawal. Patients showing signs of withdrawal will receive methadone, an opioid taken by mouth. Once off fentanyl, naloxone will be stopped. Patients will continue to be monitored for withdrawal for 4 days or until ICU discharge. If this study works, patients who receive low dose naloxone along with opioid infusions will have less tolerance and dependence and demonstrate less withdrawal. This may cause shorter Intensive Care Unit stays.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Meperidine Hydrochloride

Condition Name

Condition Name for Meperidine Hydrochloride
Intervention Trials
Pain 4
Labor Pain 4
Sedation 2
Procedural Sedation 2
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Condition MeSH

Condition MeSH for Meperidine Hydrochloride
Intervention Trials
Labor Pain 4
Gallbladder Diseases 3
Hemorrhage 2
Leukemia 2
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Clinical Trial Locations for Meperidine Hydrochloride

Trials by Country

Trials by Country for Meperidine Hydrochloride
Location Trials
United States 22
Egypt 8
Canada 6
Korea, Republic of 5
Thailand 4
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Trials by US State

Trials by US State for Meperidine Hydrochloride
Location Trials
Texas 6
California 2
New York 2
Ohio 1
North Carolina 1
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Clinical Trial Progress for Meperidine Hydrochloride

Clinical Trial Phase

Clinical Trial Phase for Meperidine Hydrochloride
Clinical Trial Phase Trials
Phase 4 22
Phase 3 4
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for Meperidine Hydrochloride
Clinical Trial Phase Trials
Completed 25
Unknown status 10
Recruiting 10
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Clinical Trial Sponsors for Meperidine Hydrochloride

Sponsor Name

Sponsor Name for Meperidine Hydrochloride
Sponsor Trials
University of Texas Southwestern Medical Center 3
M.D. Anderson Cancer Center 2
University of Alberta 2
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Sponsor Type

Sponsor Type for Meperidine Hydrochloride
Sponsor Trials
Other 77
Industry 4
NIH 1
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Serving hundreds of leading biopharmaceutical companies globally:

Teva
Dow
McKinsey
Medtronic
Mallinckrodt
Julphar
McKesson
Fish and Richardson
Baxter

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