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Last Updated: May 29, 2024

CLINICAL TRIALS PROFILE FOR MAVACAMTEN


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All Clinical Trials for Mavacamten

Trial ID Title Status Sponsor Phase Start Date Summary
NCT03442764 ↗ A Phase 2 Study of Mavacamten in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM) Completed MyoKardia, Inc. Phase 2 2018-03-30 This is a multicenter, exploratory, randomized, double-blind study of the administration of mavacamten in 60 participants with symptomatic nHCM randomized to receive a 16-week course of mavacamten doses titrated to achieve 1 of 2 target drug concentrations.
NCT03470545 ↗ Clinical Study to Evaluate Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy Completed MyoKardia, Inc. Phase 3 2018-05-29 This is a multicenter, international, double-blind study of the administration of mavacamten in participants with symptomatic obstructive HCM (oHCM). Approximately 220 participants will be randomized to receive placebo or mavacamten.
NCT03496168 ↗ Extension Study of Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy Previously Enrolled in PIONEER Active, not recruiting MyoKardia, Inc. Phase 2 2018-04-26 This is a multicenter open-label study of the administration of mavacamten in participants with symptomatic obstructive HCM (oHCM) who previously participated in study MYK-461-004 (PIONEER-HCM).
NCT03723655 ↗ A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCM Enrolling by invitation MyoKardia, Inc. Phase 2/Phase 3 2018-10-05 Approximately 30 sites that enrolled participants in the MAVERICK-HCM (MYK-461-006) study in the United States (US) will initiate this study. Approximately 90 sites that enrolled participants in the EXPLORER-HCM (MYK-461-005) study in the US, Europe, and Israel will initiate this study. Note: Approximately 30 centers overlap between MAVERICK and EXPLORER.
NCT04349072 ↗ A Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive HCM Who Are Eligible for Septal Reduction Therapy Active, not recruiting MyoKardia, Inc. Phase 3 2020-06-26 This is a randomized, double-blind, placebo-controlled, multi-center study in the United States (U.S.) that will evaluate the effect of mavacamten treatment on reducing the number of septal reduction therapy (SRT) procedures performed in subjects with symptomatic obstructive hypertrophic cardiomyopathy (oHCM [also known as HOCM]) who are eligible for SRT based on ACCF/AHA 2011 and/or ESC 2014 guidelines.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Mavacamten

Condition Name

Condition Name for Mavacamten
Intervention Trials
Healthy Participants 4
Hypertrophic Cardiomyopathy 3
Obstructive Hypertrophic Cardiomyopathy 3
Non-obstructive Hypertrophic Cardiomyopathy 2
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Condition MeSH

Condition MeSH for Mavacamten
Intervention Trials
Cardiomyopathy, Hypertrophic 9
Cardiomyopathies 9
Hypertrophy 8
Heart Failure 1
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Clinical Trial Locations for Mavacamten

Trials by Country

Trials by Country for Mavacamten
Location Trials
United States 105
Germany 10
Poland 8
Belgium 7
Brazil 7
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Trials by US State

Trials by US State for Mavacamten
Location Trials
California 7
Pennsylvania 6
Oregon 6
North Carolina 6
New York 6
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Clinical Trial Progress for Mavacamten

Clinical Trial Phase

Clinical Trial Phase for Mavacamten
Clinical Trial Phase Trials
Phase 3 5
Phase 2/Phase 3 1
Phase 2 3
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Clinical Trial Status

Clinical Trial Status for Mavacamten
Clinical Trial Phase Trials
Not yet recruiting 7
Completed 2
Active, not recruiting 2
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Clinical Trial Sponsors for Mavacamten

Sponsor Name

Sponsor Name for Mavacamten
Sponsor Trials
MyoKardia, Inc. 6
Bristol-Myers Squibb 6
LianBio LLC 2
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Sponsor Type

Sponsor Type for Mavacamten
Sponsor Trials
Industry 14
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