Temozolomide in Patients With Progressive or Recurrent Non-small Cell Lung Cancer
European Organisation for Research and Treatment of Cancer - EORTC
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die.
PURPOSE: Phase II trial to study the effect of temozolomide in patients with progressive or
recurrent stage IV non-small cell lung cancer, with or without brain metastases, who have not
been treated for metastatic disease with chemotherapy.
Effects of Tumor Necrosis Factor (TNF)-Alpha Antagonism in Patients With Metabolic Syndrome
Massachusetts General Hospital
Phase 2/Phase 3
Metabolic syndrome is associated with increased inflammatory cytokines and reduced
adiponectin, that may be mediated in part by TNF production from abdominal fat. We reasoned
that an anti-TNF agent would reduce C-reactive protein (CRP) and increase adiponectin,
improving the inflammatory milieu associated with metabolic syndrome.
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