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Generated: December 13, 2018

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CLINICAL TRIALS PROFILE FOR MALARONE

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Clinical Trials for Malarone

Trial ID Title Status Sponsor Phase Summary
NCT00421473 Drug Interaction Study Between Atovaquone and Antiretroviral Agents in HIV-1 Infected Patients Completed Radboud University Phase 4 Malarone® (atovaquone/proguanil) is frequently used in malaria prophylaxis. Unfortunately, there are indications that certain anti-HIV agents may decrease atovaquone plasma levels by induction of atovaquone metabolism. For travelling HIV patients, the clinical consequences of these possible drug drug interactions are serious, since a diminished exposure to the anti-malarial drug will result in suboptimal prophylaxis of malaria and potential development of drug resistant strains of Plasmodium falciparum. The purpose of this study is to find out if HIV patients using HAART regimes with either lopinavir/ritonavir, atazanavir/ritonavir or efavirenz have lower atovaquone plasma levels than healthy volunteers after a single dose of atovaquone/proguanil.
NCT00444106 Evaluation of Potential Effect of Artemether - Lumefantrine and Malaria Drugs on Auditory Function Completed Novartis Phase 4 To evaluate the potential effects of artemether- lumefantrine on the auditory function
NCT00984256 Weekly Dosing of Malarone ® for Prevention of Malaria Completed U.S. Army Medical Research and Materiel Command Phase 2 The purpose of this study is to determine whether Malarone ®, which is a drug approved to prevent malaria when taken daily, will still effectively prevent malaria if taken weekly.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Malarone

Condition Name

Condition Name for Malarone
Intervention Trials
Malaria 11
PCP 1
Falciparum 1
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Condition MeSH

Condition MeSH for Malarone
Intervention Trials
Malaria 12
Malaria, Falciparum 2
HIV Infections 1
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Clinical Trial Locations for Malarone

Trials by Country

Trials by Country for Malarone
Location Trials
United States 7
Netherlands 7
Colombia 1
Germany 1
France 1
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Trials by US State

Trials by US State for Malarone
Location Trials
Maryland 4
Washington 2
New York 1
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Clinical Trial Progress for Malarone

Clinical Trial Phase

Clinical Trial Phase for Malarone
Clinical Trial Phase Trials
Phase 4 4
Phase 2 2
Phase 1/Phase 2 1
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Clinical Trial Status

Clinical Trial Status for Malarone
Clinical Trial Phase Trials
Completed 9
Recruiting 4
Not yet recruiting 2
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Clinical Trial Sponsors for Malarone

Sponsor Name

Sponsor Name for Malarone
Sponsor Trials
Radboud University 5
QIMR Berghofer Medical Research Institute 2
Bill and Melinda Gates Foundation 2
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Sponsor Type

Sponsor Type for Malarone
Sponsor Trials
Other 18
U.S. Fed 3
NIH 3
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