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Last Updated: February 25, 2021

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CLINICAL TRIALS PROFILE FOR MAGNESIUM SULFATE

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All Clinical Trials for Magnesium Sulfate

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00002146 Safety and Efficacy of Intravenous Magnesium Sulfate in Modulating Changes in Symptoms and Divalent Cation Levels Associated With Foscavir Therapy: A Phase IV Randomized, Double-Blind, Placebo-Controlled, Cross-Over, Pilot Study Completed Astra USA Phase 4 1969-12-31 To determine whether acute ionized hypomagnesemia and hypocalcemia immediately following foscarnet infusions can be lessened or eliminated by prior infusion of magnesium sulfate. To determine whether reductions in ionized magnesium, ionized calcium, and parathyroid hormone levels following foscarnet infusions are lessened by preinfusion of magnesium sulfate. To evaluate the safety of intravenous magnesium sulfate prior to foscarnet infusion by monitoring blood pressure, heart rate, and heart rhythm. To characterize the effect of magnesium sulfate on foscarnet blood levels and urinary excretion of calcium, magnesium, phosphate, and foscarnet.
NCT00004399 Randomized Study of Nimodipine Versus Magnesium Sulfate in the Prevention of Eclamptic Seizures in Patients With Severe Preeclampsia Completed University of Utah N/A 1995-09-01 OBJECTIVES: I. Determine the effectiveness of nimodipine versus magnesium sulfate in the prevention of eclamptic seizures in patients with severe preeclampsia.
NCT00004399 Randomized Study of Nimodipine Versus Magnesium Sulfate in the Prevention of Eclamptic Seizures in Patients With Severe Preeclampsia Completed FDA Office of Orphan Products Development N/A 1995-09-01 OBJECTIVES: I. Determine the effectiveness of nimodipine versus magnesium sulfate in the prevention of eclamptic seizures in patients with severe preeclampsia.
NCT00004730 Magnesium Sulfate For Brain Injury Completed University of Washington Phase 3 1998-08-01 The purpose of the study is to determine whether magnesium sulfate, given within 8 hours of a moderate or severe traumatic brain injury improves survival, decreases the number of people developing seizures, improves the survivors' mental and psychological functioning, including the ability to return to daily life, live independently, and return to work or school.
NCT00007033 Study of Magnesium Sulfate in Children With Reduced Bone Density Secondary to Chronic Cholestatic Liver Disease Completed Children's Hospital Medical Center, Cincinnati N/A 2000-10-01 OBJECTIVES: I. Determine the role of magnesium deficiency in the pathogenesis of decreased serum vitamin D and reduced bone density in children with chronic cholestatic liver disease.
NCT00007033 Study of Magnesium Sulfate in Children With Reduced Bone Density Secondary to Chronic Cholestatic Liver Disease Completed National Center for Research Resources (NCRR) N/A 2000-10-01 OBJECTIVES: I. Determine the role of magnesium deficiency in the pathogenesis of decreased serum vitamin D and reduced bone density in children with chronic cholestatic liver disease.
NCT00010634 Complementary Naturopathic Medicine for Periodontitis Completed National Center for Complementary and Integrative Health (NCCIH) Phase 2 1999-09-01 This study aims to assess selected naturopathic medicines for adult periodontitis and to identify variables that influence successful outcomes when traditional and alternative approaches to preventing and treating periodontal diseases are combined. Collaboration between Kaiser Permanente, Oregon Health Science University and the National College of Naturopathic Medicine provides an unsurpassed environment for such investigations. Periodontitis is a major cause of tooth loss and negatively impacts systemic health. The limitations of traditional periodontal treatment have compelled scientists and clinicians to investigate new remedies, and naturopathic medicine holds several promising interventions. Because they are used to improve elements of host resistance that are known to be important in periodontal health and disease, three naturopathic medicines are potential adjuncts in preventing and treating periodontitis. Connective tissue components are enzymatically degraded in periodontitis. In naturopathy, Connective Tissue Nutrient Formula (CTNF) (vitamins A, C and D, glucosamine sulfate, oligoproanthocyanindins, copper, zinc, manganese, boron, silicon, magnesium, and calcium) is prescribed specifically to enhance the integrity of key connective tissue elements and improve their resistance to degradation. Periodontitis begins when permeability of the oral sulcular epithelium permits pathogenic bacterial components to invade deeper periodontal connective tissues. In naturopathy, glutamine is prescribed to reduce oral-intestinal epithelial membrane permeability. Chronic activation of the hypothalamic-pituitary-adrenal (HPA) axis during the stress response, is a risk factor for periodontitis. Adaptogenic herbs (AH) (Panax ginseng, Withania somnifera and Eleutherococcus senticosus) are prescribed by naturopathic physicians to reverse the impact of bacterial and psychosocial stressors. Because glutamine, CTNF and AH target pathophysiologic mechanisms known to underline periodontitis, they are compelling candidates in clinical and mechanistic investigations of complementary medicine approaches to the management of periodontitis. Kaiser Permanente adult periodontitis patients will serve as subjects and receive standard periodontal treatment. Three of the four randomly assigned groups will also receive supplements of glutamine, CTNF, or AH. We will determine the effects of these supplements on clinical outcomes (attachment loss, pocket depths, indicators of inflammation, plaque composition, need for periodontal surgery, acute periodontal problems, tooth loss). In addition to completing the battery of self-report measures (stress, coping, quality of life), study subjects will provide samples of blood, saliva, gingival cervicular fluid and bacterial dental plaque. These samples will be examined as part of the Laboratory Core to identify biologic and genetic characteristics that correlate with successful outcomes. Storage of portions of the samples will allow future examination of additional variables as part of the Developmental Projects carried out as the Craniofacial Complementary & Alternative Center is established and Phase III trials are undertaken.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Magnesium Sulfate

Condition Name

Condition Name for Magnesium Sulfate
Intervention Trials
Postoperative Pain 15
Preeclampsia 11
Analgesia 8
Pain 8
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Condition MeSH

Condition MeSH for Magnesium Sulfate
Intervention Trials
Pain, Postoperative 25
Pre-Eclampsia 23
Obstetric Labor, Premature 13
Asthma 12
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Clinical Trial Locations for Magnesium Sulfate

Trials by Country

Trials by Country for Magnesium Sulfate
Location Trials
United States 112
Egypt 50
Brazil 16
Canada 11
Korea, Republic of 10
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Trials by US State

Trials by US State for Magnesium Sulfate
Location Trials
New York 8
California 8
Ohio 8
Pennsylvania 7
Illinois 6
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Clinical Trial Progress for Magnesium Sulfate

Clinical Trial Phase

Clinical Trial Phase for Magnesium Sulfate
Clinical Trial Phase Trials
Phase 4 57
Phase 3 35
Phase 2/Phase 3 16
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Clinical Trial Status

Clinical Trial Status for Magnesium Sulfate
Clinical Trial Phase Trials
Completed 75
Not yet recruiting 61
Recruiting 56
[disabled in preview] 32
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Clinical Trial Sponsors for Magnesium Sulfate

Sponsor Name

Sponsor Name for Magnesium Sulfate
Sponsor Trials
Assiut University 24
Cairo University 13
Seoul National University Bundang Hospital 7
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Sponsor Type

Sponsor Type for Magnesium Sulfate
Sponsor Trials
Other 264
Industry 10
NIH 10
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