Safety and Efficacy of Intravenous Magnesium Sulfate in Modulating Changes in Symptoms and Divalent Cation Levels Associated With Foscavir Therapy: A Phase IV Randomized, Double-Blind, Placebo-Controlled, Cross-Over, Pilot Study
To determine whether acute ionized hypomagnesemia and hypocalcemia immediately following
foscarnet infusions can be lessened or eliminated by prior infusion of magnesium sulfate. To
determine whether reductions in ionized magnesium, ionized calcium, and parathyroid hormone
levels following foscarnet infusions are lessened by preinfusion of magnesium sulfate. To
evaluate the safety of intravenous magnesium sulfate prior to foscarnet infusion by
monitoring blood pressure, heart rate, and heart rhythm. To characterize the effect of
magnesium sulfate on foscarnet blood levels and urinary excretion of calcium, magnesium,
phosphate, and foscarnet.
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