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Last Updated: December 6, 2022

CLINICAL TRIALS PROFILE FOR MACITENTAN


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All Clinical Trials for Macitentan

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00660179 ↗ Study of Macitentan (ACT-064992) on Morbidity and Mortality in Patients With Symptomatic Pulmonary Arterial Hypertension Completed Actelion Phase 3 2008-05-01 The AC-055-302/SERAPHIN study will be an event-driven Phase III study, comparing two different doses of macitentan (ACT-064992) (3 and 10 mg) vs placebo in patients with symptomatic PAH. The main study objective is to demonstrate that macitentan (ACT-064992) prolongs time to the first morbidity or mortality event, and to evaluate the benefit/risk profile of macitentan (ACT-064992) in the treatment of patients with symptomatic PAH.
NCT00667823 ↗ Clinical Study to Assess the Long-term Safety and Tolerability of ACT 064992 in Patients With Symptomatic Pulmonary Arterial Hypertension Completed Actelion Phase 3 2008-10-17 The main objective of the AC 055 303/SERAPHIN OL study, which will follow the AC 055 302/SERAPHIN study, will be to assess the long-term safety and tolerability of ACT 064992 in patients with symptomatic PAH.
NCT00903331 ↗ Macitentan Use in an Idiopathic Pulmonary Fibrosis Clinical Study Completed Actelion Phase 2 2009-05-01 The AC-055B201/MUSIC study is a Phase II study, comparing one dose of ACT-064922 (macitentan) 10 mg with placebo in patients with idiopathic pulmonary fibrosis (IPF). The main study objective is to demonstrate that macitentan positively affects the forced vital capacity (FVC) in comparison with placebo in patients with idiopathic pulmonary fibrosis (IPF). The secondary objectives are to evaluate the effect of macitentan on the time to disease worsening or death in patients with IPF, and to evaluate the benefit/risk profile of macitentan in the treatment of patients with IPF.
NCT01346930 ↗ Safety and Tolerability Study of Macitentan in Patients With Idiopathic Pulmonary Fibrosis Withdrawn Actelion Phase 2 2011-07-01 The MUSIC OL study is an open-label extension study, in which all eligible patients having completed the double-blind AC-055B201/MUSIC study as scheduled receive macitentan 10 mg once daily. The study objective is to assess the long-term safety and tolerability of macitentan in patients with idiopathic pulmonary fibrosis (IPF).
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Macitentan

Condition Name

Condition Name for Macitentan
Intervention Trials
Pulmonary Arterial Hypertension 17
Healthy 9
Chronic Thromboembolic Pulmonary Hypertension 4
Healthy Subjects 4
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Condition MeSH

Condition MeSH for Macitentan
Intervention Trials
Hypertension 30
Familial Primary Pulmonary Hypertension 19
Pulmonary Arterial Hypertension 19
Hypertension, Pulmonary 11
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Clinical Trial Locations for Macitentan

Trials by Country

Trials by Country for Macitentan
Location Trials
United States 369
Canada 31
France 26
Germany 24
China 21
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Trials by US State

Trials by US State for Macitentan
Location Trials
Texas 22
Ohio 20
California 19
Massachusetts 17
Arizona 16
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Clinical Trial Progress for Macitentan

Clinical Trial Phase

Clinical Trial Phase for Macitentan
Clinical Trial Phase Trials
Phase 4 6
Phase 3 22
Phase 2/Phase 3 2
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Clinical Trial Status

Clinical Trial Status for Macitentan
Clinical Trial Phase Trials
Completed 26
Terminated 10
Recruiting 9
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Clinical Trial Sponsors for Macitentan

Sponsor Name

Sponsor Name for Macitentan
Sponsor Trials
Actelion 46
Janssen, LP 2
Covance 2
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Sponsor Type

Sponsor Type for Macitentan
Sponsor Trials
Industry 58
Other 30
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