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Last Updated: June 18, 2021

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CLINICAL TRIALS PROFILE FOR LUTETIUM DOTATATE LU-177

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All Clinical Trials for Lutetium Dotatate Lu-177

Trial ID Title Status Sponsor Phase Start Date Summary
NCT02358356 Capecitabine ON Temozolomide Radionuclide Therapy Octreotate Lutetium-177 NeuroEndocrine Tumours Study Recruiting Australasian Gastro-Intestinal Trials Group Phase 2 2015-11-01 Two parallel phase II randomized open label trials of Lutetium-177 Octreotate (177Lu‐Octreotate) peptide receptor radionuclide therapy (PRRT) and capecitabine (CAP)/temozolomide (TEM) chemotherapy (chemo): (i) versus CAPTEM alone in the treatment of low to intermediate grade pancreatic neuroendocrine tumours (pNETs); (ii) versus PRRT alone in the treatment of low to intermediate grade mid gut neuroendocrine tumours (mNETs).
NCT02743741 Lu-DOTATATE Treatment in Patients With 68Ga-DOTATATE Somatostatin Receptor Positive Neuroendocrine Tumors Recruiting Canadian Molecular Imaging Probe Consortium N/A 2016-07-01 This is a prospective single arm, multicenter study will evaluate the efficacy and safety of Lutetium-177 Octreotate in patients with neuroendocrine tumors who has positive Somatostatin receptor identified by 68Ga-DOTATATE. 195 patients will be enrolled totally. Patient who has progressed with neuroendocrine tumor will be evaluated by the tumor board first and eligible patients will undergo diagnostic Ga 68 PET scan. Patients who showed Somatostatin will undergo 4 cycles of Lu-DOTATATE treatment. Dose adjustment for Cycle 2-4 will be made based on individualized dosimetry, as well as creatinine clearance and hematological parameters. Patients will be evaluated progression free survival at 12 months from last dose. Patients who are negative for somatostatin will not receive 68Ga-DOTATATE treatment but will be followed until progression and acts as control group.
NCT02743741 Lu-DOTATATE Treatment in Patients With 68Ga-DOTATATE Somatostatin Receptor Positive Neuroendocrine Tumors Recruiting Cancer Care Ontario N/A 2016-07-01 This is a prospective single arm, multicenter study will evaluate the efficacy and safety of Lutetium-177 Octreotate in patients with neuroendocrine tumors who has positive Somatostatin receptor identified by 68Ga-DOTATATE. 195 patients will be enrolled totally. Patient who has progressed with neuroendocrine tumor will be evaluated by the tumor board first and eligible patients will undergo diagnostic Ga 68 PET scan. Patients who showed Somatostatin will undergo 4 cycles of Lu-DOTATATE treatment. Dose adjustment for Cycle 2-4 will be made based on individualized dosimetry, as well as creatinine clearance and hematological parameters. Patients will be evaluated progression free survival at 12 months from last dose. Patients who are negative for somatostatin will not receive 68Ga-DOTATATE treatment but will be followed until progression and acts as control group.
NCT02743741 Lu-DOTATATE Treatment in Patients With 68Ga-DOTATATE Somatostatin Receptor Positive Neuroendocrine Tumors Recruiting Ozmosis Research Inc. N/A 2016-07-01 This is a prospective single arm, multicenter study will evaluate the efficacy and safety of Lutetium-177 Octreotate in patients with neuroendocrine tumors who has positive Somatostatin receptor identified by 68Ga-DOTATATE. 195 patients will be enrolled totally. Patient who has progressed with neuroendocrine tumor will be evaluated by the tumor board first and eligible patients will undergo diagnostic Ga 68 PET scan. Patients who showed Somatostatin will undergo 4 cycles of Lu-DOTATATE treatment. Dose adjustment for Cycle 2-4 will be made based on individualized dosimetry, as well as creatinine clearance and hematological parameters. Patients will be evaluated progression free survival at 12 months from last dose. Patients who are negative for somatostatin will not receive 68Ga-DOTATATE treatment but will be followed until progression and acts as control group.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Lutetium Dotatate Lu-177

Condition Name

Condition Name for Lutetium Dotatate Lu-177
Intervention Trials
Neuroendocrine Tumors 4
Recurrent Breast Carcinoma 1
Metastatic Adrenal Gland Pheochromocytoma 1
Stage IVB Thyroid Gland Medullary Carcinoma AJCC v8 1
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Condition MeSH

Condition MeSH for Lutetium Dotatate Lu-177
Intervention Trials
Neuroendocrine Tumors 8
Carcinoid Tumor 3
Neoplasms 3
Carcinoma 2
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Clinical Trial Locations for Lutetium Dotatate Lu-177

Trials by Country

Trials by Country for Lutetium Dotatate Lu-177
Location Trials
United States 5
Australia 4
Netherlands 1
Canada 1
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Trials by US State

Trials by US State for Lutetium Dotatate Lu-177
Location Trials
Iowa 1
Kentucky 1
Oregon 1
Texas 1
Minnesota 1
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Clinical Trial Progress for Lutetium Dotatate Lu-177

Clinical Trial Phase

Clinical Trial Phase for Lutetium Dotatate Lu-177
Clinical Trial Phase Trials
Phase 2/Phase 3 1
Phase 2 6
Phase 1/Phase 2 1
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Clinical Trial Status

Clinical Trial Status for Lutetium Dotatate Lu-177
Clinical Trial Phase Trials
Not yet recruiting 9
Recruiting 2
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Clinical Trial Sponsors for Lutetium Dotatate Lu-177

Sponsor Name

Sponsor Name for Lutetium Dotatate Lu-177
Sponsor Trials
National Cancer Institute (NCI) 6
National Institutes of Health (NIH) 1
Canadian Molecular Imaging Probe Consortium 1
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Sponsor Type

Sponsor Type for Lutetium Dotatate Lu-177
Sponsor Trials
Other 11
NIH 7
Industry 4
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