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Last Updated: October 20, 2019

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CLINICAL TRIALS PROFILE FOR LUPRON

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Clinical Trials for Lupron

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00001181 Testolactone for the Treatment of Girls With LHRH Resistant Precocious Puberty Completed Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Phase 2 1982-10-01 The normal changes of puberty, such as breast enlargement, pubic hair and menstrual periods, usually begin between the ages of 9 and 15 in response to hormones produced in the body. Some children's bodies produce these hormones before the normal age and start puberty too early. This condition is known as precocious puberty. The hormones responsible for the onset of puberty come from the pituitary gland and the ovaries. The hormones from the pituitary gland act on the ovaries to produce different hormones that cause the breasts to grow, pubic hair to develop, and menstruation. Many children with precocious puberty can be treated with a medication known as lutenizing hormone-releasing hormone analog (Lupron, Histerelin, Deslorelin). This drug is made in a laboratory and is designed to act like the natural hormone LHRH, which is made in the pituitary gland. The drug causes the pituitary gland to decrease the amount of hormones it is releasing and thereby decrease the amount of hormones released by the ovaries. However, some girls already have low levels of pituitary hormones and yet their ovaries still produce hormones. Researchers do not believe that LHRH analog therapy will work for these children. Testolactone is a drug that acts directly on the ovary. It works by preventing the last step of estrogen production in the ovary. The goal of this treatment is to stop estrogen production and delay the onset of puberty until the normal age. Researchers will give patients with LHRHa resistant precocious puberty Testolactone for six months. If the initial treatment is successful and patients do not experience very bad side effects, they will continue to receive the medication until puberty is desired. Throughout the therapy patients will receive frequent monitoring of their general state of health, hormone levels, and medication levels.
NCT00001481 The Role of Hormones in Postpartum Mood Disorders Suspended National Institute of Mental Health (NIMH) Phase 2 1996-04-26 Determine whether postpartum depression is triggered by the abrupt withdrawal of estrogen and progesterone. The appearance of mood and behavioral symptoms during pregnancy and the postpartum period has been extensively reported. While there has been much speculation about possible biologically based etiologies for postpartum disorders (PPD), none has ever been confirmed. Preliminary results from two related studies (protocols 90-M-0088, 92-M-0174) provide evidence that women with menstrual cycle related mood disorder, but not controls, experience mood disturbances during exogenous replacement of physiologic levels of gonadal steroids. The present protocol is designed to create a "scaled-down" hormonal milieu of pregnancy and the puerperium in order to determine whether women who have had a previous episode of postpartum major effective episode will experience differential mood and behavioral effects compared with controls and to determine whether it is the abrupt withdrawal of gonadal steroids or the prolonged exposure to gonadal steroids that is associated with mood symptoms. Supraphysiologic plasma levels of gonadal steroids will be established, maintained, and then rapidly reduced, simulating the hormonal events that occur during pregnancy and parturition. This will be accomplished by administering estradiol and progesterone to women who are pretreated with a gonadotropin releasing hormone (GnRH) agonist (Lupron). After eight weeks, administration of gonadal steroids will be stopped in one group of patients and controls, and a sudden decline in the plasma hormone levels will be precipitated. Another group will be maintained on supraphysiologic levels of estrogen and progesterone for an additional month. Outcome measures will include mood, behavioral and hormonal parameters as well as response to o-CRH (a separate protocol done in collaboration with NICHD).
NCT00099086 Docetaxel, Radiation Therapy, and Hormone Therapy in Treating Patients With Locally Advanced Prostate Cancer Active, not recruiting David T. Marshall Phase 1 2010-07-01 This phase I trial is studying the side effects and best dose of docetaxel when given with radiation therapy and hormone therapy in patients with locally advanced prostate cancer.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Lupron

Condition Name

Condition Name for Lupron
Intervention Trials
Prostate Cancer 31
Infertility 5
Endometriosis 4
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Condition MeSH

Condition MeSH for Lupron
Intervention Trials
Prostatic Neoplasms 38
Puberty, Precocious 5
Infertility 5
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Clinical Trial Locations for Lupron

Trials by Country

Trials by Country for Lupron
Location Trials
United States 230
Canada 14
Netherlands 7
Italy 6
France 5
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Trials by US State

Trials by US State for Lupron
Location Trials
Texas 18
California 18
New York 16
Maryland 14
Pennsylvania 13
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Clinical Trial Progress for Lupron

Clinical Trial Phase

Clinical Trial Phase for Lupron
Clinical Trial Phase Trials
Phase 4 9
Phase 3 18
Phase 2/Phase 3 2
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Clinical Trial Status

Clinical Trial Status for Lupron
Clinical Trial Phase Trials
Completed 33
Recruiting 16
Not yet recruiting 10
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Clinical Trial Sponsors for Lupron

Sponsor Name

Sponsor Name for Lupron
Sponsor Trials
M.D. Anderson Cancer Center 9
Abbott 6
Dana-Farber Cancer Institute 6
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Sponsor Type

Sponsor Type for Lupron
Sponsor Trials
Other 83
Industry 42
NIH 17
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