Comparison of Acular LS With Lotemax to Prevent Inflammation After Cataract Surgery and Intraocular Lens Implantation
Completed
Medical University of South Carolina
Phase 4
2006-02-01
The purpose of this study is to compare the effectiveness of Acular LS® and Lotemax® in the
prevention of inflammation in the eye after cataract surgery. Acular LS is made by Allergan,
Inc. It is a nonsteroidal anti-inflammatory drug (NSAID) and is approved by the Food and Drug
Administration (FDA) for use following cataract surgery. Lotemax is made by Bausch & Lomb. It
is a steroid and is also approved by the FDA for use following cataract surgery.
Multicenter, Randomized, Controlled Study of the Effect of Lotemax on Initiation of Dry Eye Treatment With Restasis
Completed
Bausch & Lomb Incorporated
Phase 4
2006-11-01
To evaluate the impact of Lotemax on the initiation of Restasis therapy in patients with dry
eye.
It is hypothesized that the anti-inflammatory activity of Lotemax may help mitigate the
stinging with cyclosporine administration and the dry eye signs and symptoms experienced
during the initiation of therapy.
Multicenter, Randomized, Controlled Study of the Effect of Lotemax on Initiation of Dry Eye Treatment With Restasis
Completed
Ophthalmic Consultants of Long Island
Phase 4
2006-11-01
To evaluate the impact of Lotemax on the initiation of Restasis therapy in patients with dry
eye.
It is hypothesized that the anti-inflammatory activity of Lotemax may help mitigate the
stinging with cyclosporine administration and the dry eye signs and symptoms experienced
during the initiation of therapy.
Loteprednol Etabonate Opthalmic Suspension for the Treatment of Dry Eye
Completed
Bausch & Lomb Incorporated
Phase 2
2005-11-01
This was a single-center, randomized, double-masked, placebo-controlled, parallel-group,
4-visit, CAE (Controlled Adverse Environment) study lasting approximately 4 weeks. Subjects
were randomized to receive loteprednol etabonate ophthalmic suspension, 0.5% or placebo
(vehicle of loteprednol etabonate ophthalmic suspension, 0.5%) and instructed to dose
bilaterally either TID or QID according to randomization.
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