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Generated: December 17, 2018

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CLINICAL TRIALS PROFILE FOR LOPRESSOR HCT

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Clinical Trials for Lopressor Hct

Trial ID Title Status Sponsor Phase Summary
NCT00123604 Vascular Effects of Carvedilol Versus Metoprolol in Hypertensive Patients With Type 2 Diabetes Completed GlaxoSmithKline Phase 4 The purpose of this study is to compare the vascular effects of two commonly used blood pressure medications, carvedilol and metoprolol in hypertensive patients with type 2 diabetes.
NCT00123604 Vascular Effects of Carvedilol Versus Metoprolol in Hypertensive Patients With Type 2 Diabetes Completed St. Paul Heart Clinic Phase 4 The purpose of this study is to compare the vascular effects of two commonly used blood pressure medications, carvedilol and metoprolol in hypertensive patients with type 2 diabetes.
NCT00223717 Treatment of Supine Hypertension in Autonomic Failure Recruiting Vanderbilt University Medical Center Phase 1/Phase 2 Supine hypertension is a common problem that affects at least 50% of patients with primary autonomic failure. Supine hypertension can be severe, and complicates the treatment of orthostatic hypotension. Drugs used for the treatment of orthostatic hypotension (eg, fludrocortisone and pressor agents), worsen supine hypertension. High blood pressure may also cause target organ damage in this group of patients. The pathophysiologic mechanisms causing supine hypertension in patients with autonomic failure have not been defined. In a study, we, the investigators at Vanderbilt University, examined 64 patients with AF, 29 with pure autonomic failure (PAF) and 35 with multiple system atrophy (MSA). 66% of patients had supine systolic (systolic blood pressure [SBP] > 150 mmHg) or diastolic (diastolic blood pressure [DBP] > 90 mmHg) hypertension (average blood pressure [BP]: 179 ± 5/89 ± 3 mmHg in 21 PAF and 175 ± 5/92 ± 3 mmHg in 21 MSA patients). Plasma norepinephrine (92 ± 15 pg/mL) and plasma renin activity (0.3 ± 0.05 ng/mL per hour) were very low in a subset of patients with AF and supine hypertension. (Shannon et al., 1997). Our group has showed that a residual sympathetic function contributes to supine hypertension in patients with severe autonomic failure and that this effect is more prominent in patients with MSA than in those with PAF (Shannon et al., 2000). MSA patients had a marked depressor response to low infusion rates of trimethaphan, a ganglionic blocker; the response in PAF patients was more variable. At 1 mg/min, trimethaphan decreased supine SBP by 67 +/- 8 and 12 +/- 6 mmHg in MSA and PAF patients, respectively (P < 0.0001). MSA patients with supine hypertension also had greater SBP response to oral yohimbine, a central alpha2 receptor blocker, than PAF patients. Plasma norepinephrine decreased in both groups, but heart rate did not change in either group. This result suggests that residual sympathetic activity drives supine hypertension in MSA; in contrast, supine hypertension in PAF. It is hoped that from this study will emerge a complete picture of the supine hypertension of autonomic failure. Understanding the mechanism of this paradoxical hypertension in the setting of profound loss of sympathetic function will improve our approach to the treatment of hypertension in autonomic failure, and it could also contribute to our understanding of hypertension in general.
Trial ID Title Status Sponsor Phase Summary

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Clinical Trial Conditions for Lopressor Hct

Condition Name

Condition Name for Lopressor Hct
Intervention Trials
Hypertension 8
Healthy 6
Atrial Fibrillation 4
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Condition MeSH

Condition MeSH for Lopressor Hct
Intervention Trials
Hypertension 6
Atrial Fibrillation 4
Pure Autonomic Failure 2
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Clinical Trial Locations for Lopressor Hct

Trials by Country

Trials by Country for Lopressor Hct
Location Trials
United States 24
Canada 4
France 1
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Trials by US State

Trials by US State for Lopressor Hct
Location Trials
West Virginia 3
Tennessee 3
Minnesota 3
Florida 2
North Dakota 2
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Clinical Trial Progress for Lopressor Hct

Clinical Trial Phase

Clinical Trial Phase for Lopressor Hct
Clinical Trial Phase Trials
Phase 4 8
Phase 3 2
Phase 2/Phase 3 1
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Clinical Trial Status

Clinical Trial Status for Lopressor Hct
Clinical Trial Phase Trials
Completed 13
Recruiting 5
Active, not recruiting 1
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Clinical Trial Sponsors for Lopressor Hct

Sponsor Name

Sponsor Name for Lopressor Hct
Sponsor Trials
Forest Laboratories 4
Mylan Pharmaceuticals 4
Vanderbilt University 2
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Sponsor Type

Sponsor Type for Lopressor Hct
Sponsor Trials
Other 18
Industry 12
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Serving hundreds of leading biopharmaceutical companies globally:

Dow
Mallinckrodt
Baxter
Julphar
Daiichi Sankyo
Farmers Insurance
QuintilesIMS
Citi
Colorcon

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