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Last Updated: March 5, 2024

CLINICAL TRIALS PROFILE FOR LIOTHYRONINE SODIUM


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All Clinical Trials for Liothyronine Sodium

Trial ID Title Status Sponsor Phase Start Date Summary
NCT00004062 ↗ Azacitidine to Restore Thyroid Function in Patients With Persistent or Metastatic Thyroid Cancer Completed National Cancer Institute (NCI) Phase 1 1999-07-01 RATIONALE: Azacitidine may help thyroid cancer cells regain the ability to take up iodine. This would allow the cancer to be detected and treated by radioactive iodine. PURPOSE: Phase I trial to study the effectiveness of azacitidine to restore thyroid function in treating patients who have persistent or metastatic thyroid cancer.
NCT00004062 ↗ Azacitidine to Restore Thyroid Function in Patients With Persistent or Metastatic Thyroid Cancer Completed Lucille P. Markey Cancer Center at University of Kentucky Phase 1 1999-07-01 RATIONALE: Azacitidine may help thyroid cancer cells regain the ability to take up iodine. This would allow the cancer to be detected and treated by radioactive iodine. PURPOSE: Phase I trial to study the effectiveness of azacitidine to restore thyroid function in treating patients who have persistent or metastatic thyroid cancer.
NCT00027417 ↗ Study of Triostat in Infants During Heart Surgery Completed Michael Portman Phase 3 2001-04-01 This is a study to determine the safety and efficacy of liothyronine sodium/triiodothyronine (Triostat), a synthetic thyroid hormone, when given to infants with congenital heart disease during cardiopulmonary bypass surgery.
NCT00098852 ↗ Rosiglitazone in Treating Patients With Locoregionally Extensive or Metastatic Thyroid Cancer Unknown status National Cancer Institute (NCI) Phase 2 2004-10-01 RATIONALE: Drugs such as rosiglitazone may make tumor cells more sensitive to radioactive iodine. PURPOSE: This phase II trial is studying how well rosiglitazone works in treating patients with locoregionally extensive or metastatic thyroid cancer.
NCT00098852 ↗ Rosiglitazone in Treating Patients With Locoregionally Extensive or Metastatic Thyroid Cancer Unknown status University of California, San Francisco Phase 2 2004-10-01 RATIONALE: Drugs such as rosiglitazone may make tumor cells more sensitive to radioactive iodine. PURPOSE: This phase II trial is studying how well rosiglitazone works in treating patients with locoregionally extensive or metastatic thyroid cancer.
NCT00311987 ↗ Study of 3,5-Diiodothyropropionic Acid (DITPA) in Hypercholesterolemic Patients Terminated Johns Hopkins University Phase 1/Phase 2 2006-04-01 The natural thyroid hormones, thyroxine (T4) and triiodothyronine (T3), are known to have a cholesterol-lowering effect. Their pharmacologic use for this purpose is limited, however, by their actions on other organs, including the heart, bone, and brain, where there can be side effects of excessive thyroid hormone action. 3,5-diiodothyropropionic acid (DITPA) is a thyroid hormone analog with relative selectivity for a form of the thyroid hormone receptor expressed in the liver, where it regulates several aspects of lipid metabolism, including the clearance of low-density lipoprotein (LDL) cholesterol. This study is designed to determine whether DITPA is safe and effective in achieving LDL cholesterol levels that are consistent with the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) guidelines in patients who have not achieved those levels on conventional therapy, due to drug-resistant disease, drug intolerance, or both. This is a single-center, randomized, double-blind, placebo-controlled study. Following a 4-week Pre-Randomization Phase with dietary counseling and a 2-week placebo run-in, eligible patients will be randomized (1:1:1) to receive DITPA (90 mg/day, 180 mg/day), or placebo for a total treatment duration of 12 weeks. Sixty (60) patients will be randomized to 1 of 3 treatment groups in a 1:1:1 ratio (i.e., 20 patients per treatment group): - DITPA at 90 mg/day (45 mg twice a day [BID] taken orally) - DITPA at 180 mg/day (90 mg BID taken orally) - Placebo (BID taken orally) Those patients randomized to receive DITPA at 90 mg/day will receive 45 mg/day for the first 2 weeks, followed by 90 mg/day for 10 weeks. Those patients randomized to receive DITPA at 180 mg/day will receive 45 mg/day for the first 2 weeks, followed by 90 mg/day for the next 2 weeks, and then 180 mg/day for 8 weeks.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for Liothyronine Sodium

Condition Name

Condition Name for Liothyronine Sodium
Intervention Trials
Head and Neck Cancer 2
Healthy 2
Metastatic Breast Cancer 1
Multiple Sclerosis 1
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Condition MeSH

Condition MeSH for Liothyronine Sodium
Intervention Trials
Thyroid Diseases 4
Thyroid Neoplasms 3
Head and Neck Neoplasms 2
Heart Defects, Congenital 2
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Clinical Trial Locations for Liothyronine Sodium

Trials by Country

Trials by Country for Liothyronine Sodium
Location Trials
United States 14
Korea, Republic of 1
Indonesia 1
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Trials by US State

Trials by US State for Liothyronine Sodium
Location Trials
District of Columbia 2
Minnesota 2
Maryland 2
California 2
Washington 2
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Clinical Trial Progress for Liothyronine Sodium

Clinical Trial Phase

Clinical Trial Phase for Liothyronine Sodium
Clinical Trial Phase Trials
Phase 3 3
Phase 2 4
Phase 1/Phase 2 2
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Clinical Trial Status

Clinical Trial Status for Liothyronine Sodium
Clinical Trial Phase Trials
Completed 9
Unknown status 2
Recruiting 2
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Clinical Trial Sponsors for Liothyronine Sodium

Sponsor Name

Sponsor Name for Liothyronine Sodium
Sponsor Trials
National Cancer Institute (NCI) 4
Ipe, LLC 2
University of Minnesota - Clinical and Translational Science Institute 1
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Sponsor Type

Sponsor Type for Liothyronine Sodium
Sponsor Trials
Other 14
NIH 4
Industry 4
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