Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Irregular or prolonged menstrual bleeding and/or spotting are common side effects in
patients using progestin-only hormonal contraception such as levonorgestrel implants
(Norplant). Doxycycline, a drug approved by the Food and Drug Administration (FDA) to treat
gum disease, may reduce the occurrence of uterine bleeding and spotting in women who use
Norplant. This study will evaluate the effects of doxycycline on uterine bleeding/spotting
in women using Norplant.
A Study to Evaluate Suppression of the Pituitary-Ovarian Axis With Three Different Oral Contraceptive Regimens
This is a randomized, open-label study to evaluate pituitary ovarian suppression in healthy,
reproductive-aged women using three different regimens of oral contraceptives (OCs). Two
extended regimen OCs, Seasonale (levonorgestrel/ethinyl estradiol 0.15/0.03 mg for 84 days
followed by 7 days of placebo), and Seasonique (levonorgestrel/ethinyl estradiol 0.15/0.03
mg for 84 days followed by 7 days of ethinyl estradiol 0.01 mg), and a 28-day regimen OC,
Portia (levonorgestrel/ethinyl estradiol 0.15/0.03 mg for 21 days followed by 7 days of
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